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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 1/2021

Open Access 01-12-2021 | Chronic Obstructive Lung Disease | Research

Electrophysiological biomarkers of central nervous system affection in cases of chronic obstructive pulmonary disease (COPD)

Authors: Hossam Abd El Monem Ali, Ahmed Salama Al-Adl

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2021

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Abstract

Background

Chronic obstructive pulmonary disease is associated with significant systemic abnormalities which includes systemic inflammation and neurohormonal activation that are considered the main mechanisms of the pathophysiology in systemic involvement. The aim of the present study was to detect the subclinical affection of the central nervous system in patients with stable chronic obstructive pulmonary disease.

Results

Forty patients with chronic obstructive pulmonary disease were enrolled in this study and 30 healthy subjects as a control group. All patients and healthy subjects were submitted to full history taking, clinical examination, arterial blood gases, spirometry, evoked potential, and electroencephalogram. Regarding to brain stem auditory evoked potentials, there was a statistically significant increase of latency of waves numbers I, III, and V, and a statistically significant increase of interpeak latencies I–III in the COPD group when compared to the control group. On the other hand, there was a statistically significant decrease of brain stem auditory evoked potential I and V amplitudes on both sides in the COPD group when compared to the control group. In visual evoked potential, there was a statistically significant increase of latency and decrease of amplitude of P100. In addition, there was a statistically significant increase of electroencephalogram changes in the COPD group when compared to the control group (20.0% vs. 3.3%, respectively).

Conclusion

In patients with chronic obstructive pulmonary disease, the central nervous system could be affected subclinically as the severity of chronic obstructive pulmonary disease increased, and the patient should be electrophysiologically monitored for early detection of nervous system affection.
Literature
1.
Jiang Z, Zhu L. Update on molecular mechanisms of corticosteroid resistance in chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2016;37:1–8.CrossRef
2.
Kazi K, Mehta A, Mulla M. Electrophysiological evaluation of peripheral nerves in patients with COPD. IJBAP. 2012;1(1):83–7.
3.
Tkác J, Man SF, Sin DD. Systemic consequences of COPD. Ther Adv Respir Dis. 2007;1:47–59.CrossRef
4.
5.
Doehner W, Haeusler KG, Lainscak M. Neurological and endocrinological disorders: orphans in COPD. Respir Med. 2011;105(Suppl 1):S12–9.CrossRef
6.
Kirkil G, Tug T, Muz MH. The evaluation of cognitive functions with P300 test for COPD patients in attack and stable period. Clin Neurol Neurosurg. 2007;109:553–60.CrossRef
7.
Agrawal D, Vohra R, Gupta P. Subclinical peripheral neuropathy in stable middle-aged patients with COPD. Singapore Med J. 2007;48(10):887.PubMed
8.
Global Initiative for Chronic Obstructive Lung Disease (GOLD) (2014): Global strategy for the diagnosis, management and prevention of COPD; 2014. Available at: http://​www.​goldcopd.​org. Accessed 4 Feb 2015
9.
American thoracic society. Standard for the diagnosis and care of patients with COPD. Am J Respir Crit Care Med. 1995;152:S77–121.
10.
American Thoracic Society, European Respiratory Society. American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2003;168:818.CrossRef
11.
Karl E. Misulis and Thomas C. Head. Brainstem auditory evoked potentials, Visual evoked potentials. Part II: Electroencephalography. In: Karl E. Misulis and Thomas C. Essential of clinical neurophysiology; 3rd edition. Garland Science; 2003.191-208, 37-83.
12.
Calik-Kutukcu E, Savci S, Saglam M. A comparison of muscle strength and endurance, exercise capacity, and fatigue in patients with COPD and healthy subjects: a cross-sectional study. BMC Pulmon Med. 2014;14:6–13.CrossRef
13.
Karthikkeyan K, Padma K, Rao VB. Evaluation of Visual Evoked Potential in Patients with COPD. Indian J Physiol Pharmacol. 2015;59(2):182–8.PubMed
14.
Kayacan O, Beder S, Karnak D. Neurophysiological changes in COPD patients with chronic respiratory insufficiency. Acta Neurol Belg. 2001;101:160–5.PubMed
15.
Ozge A, Atis S, Sevim S. Subclinical peripheral neuropathy associated with COPD. Electromyogr Clin Neurophysiol. 2001;41:185–91.PubMed
16.
Gupta PP, Sood S, Agarwal D. Assessment of VEP in stable COPD patients with no visual impairment. Ann Thorac Med. 2010;5:222–7.CrossRef
17.
Atis S, Ozge A, Sevim S. The brainstem auditory evoked potential abnormalities in severe COPD. Respirology. 2001;6:225–9.CrossRef
18.
Shalabi N, Abdel El-Salam M, Abbas A. Brain-stem auditory evoked responses in COPD patients. Egypt J Chest Dis Tuberc. 2012;61:313–21.CrossRef
19.
MA EK, Tawfik S, Durrant D. Study of auditory function in patients with COPD. Hear Res. 2006;212:109–16.CrossRef
20.
Liu D, Chen Q, Huang Z, Zhong J, Zhou L. Auditory brainstem response in severe obstructive sleep apnea-hypopnea syndrome children. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005;19(19):868–70.PubMed
21.
Barbieri S, Fayoumi Z, Berardinelli P. Evidence for a subclinical involvement of the central nervous system in mild or moderate chronic respiratory insufficiency. Electromyogr Clin Neurophysiol. 1996;36:67–72.PubMed
22.
Nakano S, Imamura S, Hashimoto I. Evoked potentials in patients with chronic respiratory insufficiency. Intern Med. 1997;36:270–5.CrossRef
23.
Chiappa KA. Brainstem auditory evoked potentials: Methodology. In: Chiappa KA, editor. Evoked Potentials in Clinical Medicine. 3rd ed. USA: Lippincott-Raven Publishers; 1997. p. 157–98.
24.
Mikaeili H, Yazdchi M, Sadeghi-Hokmabadi E. Correlation between optic nerve involvement and COPD. Clin Ophthalmol. 2015;9:271–4.PubMedPubMedCentral
25.
Demir HD, Inonu H, Etikan I. Evaluation of visual field parameters with COPD. Acta Ophthalmol. 2012;90:e349–54.CrossRef
26.
Singh SB, Thakur L, Anand JP. Changes in visual evoked potentials on acute induction to high altitude. Indian J Med Res. 2004;120:472–7.PubMed
27.
Sezer M, Yaman M, Oruc S. Visual evoked potential changes in COPD. Eur J Gen Med. 2007;4:115–8.
28.
Ozge C, Ozge A, Unal O. Cognitive and functional deterioration in patients with severe COPD. Behav Neurol. 2006;17:121–30.CrossRef
29.
Sohmer H, Freeman S, Malachi S. Multi-modality evoked potentials in hypoxemia. Electroencephalogr Clin Neurophysiol. 1986;64:328–33.CrossRef
30.
Gunn AJ, Cook CJ, Gluckman PD. Electrophysiological responses of the fetus to hypoxia and asphyxia. J Dev Physiol. 1991;16:147–53.PubMed
31.
John J, Venugopal P, Shaji CV. A study of electro encephalo graphic changes and cognitive functions in patients with chronic obstructive pulmonary disease with different grades of bode severity. Int J Contemp Med Res. 2016;3(11):3330–3.
32.
Bernhard R, Melanie S, Stefan K. Neurovascular coupling and EEG band distribution in patients with chronic obstructive pulmonary disease. Int J Clin Neurosci Ment Health. 2014;1:3.
Metadata
Title
Electrophysiological biomarkers of central nervous system affection in cases of chronic obstructive pulmonary disease (COPD)
Authors
Hossam Abd El Monem Ali
Ahmed Salama Al-Adl
Publication date
01-12-2021
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1186/s41983-021-00311-6

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