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Clinical Collections
Women’s Health Knowledge Hub Advances in Alzheimer’s

Navigating neuroimaging in Alzheimer disease care

PET imaging is playing an increasingly critical role in managing AD, but how can you effectively integrate it into clinical practice? Our expert-led program will empower you with practical strategies and real-world case studies.

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Multiple Sclerosis

Vitamin D reduces disease activity risk in patients with early signs of MS

High doses of vitamin D could significantly reduce the risk for disease activity in people with clinically isolated syndrome or early relapsing-remitting multiple sclerosis.

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Editor's Choice

Menarche transition associated with increased MS disease activity

Multiple sclerosis in girls with pediatric onset tends to occur in the 2–3 years after menarche, and the risk for relapse is increased during and following menarche.

Vaccines for neurological disease

How far off are vaccine-based approaches to prevent and modify the progression of diseases such as Alzheimers, Parkinsons, multiple sclerosis, Huntingtons, ALS, and CJD?

Atypical optic neuritis

What are the most common causes and manifestations of atypical optic neuritis, and how should you treat them?

Stopping DMT can trigger inflammatory disease in stable MS

Discontinuing first-line disease-modifying therapy for multiple sclerosis can lead to recurrence of inflammatory disease activity in patients with stable disease.

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Keynote webinar | Spotlight on sleep in brain health

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
Developed by: Springer Medicine
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Video

Latest News

Vitamin D reduces disease activity risk in patients with early signs of MS

Menarche transition associated with increased MS disease activity

MS increases mental illness risk in perinatal period

Stopping DMT can trigger inflammatory disease in stable MS

Evobrutinib not recommended for relapsing MS

Benefits of ofatumumab over teriflunomide for MS consistent across racial groups

Case Studies

MOGAD: clinical relapse after 52 years

An attack of optic neuritis after a remarkably prolonged interval, illustrating the variable disease course in myelin oligodendrocyte glycoprotein antibody-associated disease. How should you manage recurrent optic neuritis?

Thunderclap headache due to ADEM

Thunderclap headache as a first clinical manifestation of acute disseminated encephalomyelitis has not been described before, and significant intracranial hypertension in ADEM is rarely reported. This unusual case combines both.

Evolving disease: viral to autoimmune encephalitis to MS

This unique case tracks the evolution from infectious to autoimmune encephalitis to multiple sclerosis in one patient, providing novel insights into the pathophysiology of neuroimmunological disorders.

Episode 4: Stem cell therapy for PD

A new era for managing Parkinson’s disease?

STEM-PD, the first in-human safety trial of stem cell therapy for Parkinson’s disease, began this year and marks a huge step forward for this type of treatment.

We talk to Prof. Malin Parmar about why stem cell therapy is such a good option for patients with Parkinson’s disease and get an update on the current status of the trial.

Dr. Malin Parmar
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Podcast

Current Reviews

MOG antibody-positive patients meeting diagnostic criteria for MS: is it MOGAD with an MS-like phenotype or true MS?

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a recently recognized disorder distinct from multiple sclerosis (MS) and neuromyelitis optica spectrum disorder. The introduction of diagnostic criteria for MOGAD in …

Safety and effectiveness of diroximel fumarate in relapsing forms of multiple sclerosis: a systematic review and meta-analysis

Multiple sclerosis (MS) is a chronic, immune-mediated disease characterized by inflammation of the central nervous system (CNS), demyelination, and axonal degeneration. It is estimated to affect more than 2.9 million people worldwide. The major …

Clinical and radiological activity after extended interval and standard interval dosing of ocrelizumab in multiple sclerosis: A systematic review and meta-analysis

Despite tremendous advances in modifying the course of relapsing multiple sclerosis (RMS), long-term management of this disease remains challenging. Most patients with this condition are diagnosed at a young age and, in the absence of curative …

The Evolution of Anti-CD20 Treatment for Multiple Sclerosis: Optimization of Antibody Characteristics and Function

B-cell depletion with CD20-targeted agents is commonly used for treatment of multiple sclerosis (MS), other autoimmune diseases, and certain hematologic malignancies. Initial apparent success with rituximab in MS and neuromyelitis optica spurred …

Further Reading

Burnout Among Physicians Treating Patients with Multiple Sclerosis in the United States: A Podcast

Physician burnout, a growing crisis in the healthcare system of the United States of America (USA), is characterized by long-term job-related stress that manifests as energy depletion, feelings of increased mental distance from or cynicism toward …

User requirements for quantitative radiological reports in multiple sclerosis

Multiple sclerosis (MS) is a chronic neurological condition characterized by a wide spectrum of symptoms often leading to progressive and irreversible disability [ 1 ]. Magnetic resonance imaging (MRI) plays a crucial role in the diagnosis and …

Evaluation of dried blood spot sampling for verification of exposure to chemical threat agents

  • Open Access
  • Opioids
  • Original Article

Organophosphorus nerve agents (OPNAs) are potent and irreversible inhibitors of acetylcholinesterase (AChE). Inhibition of AChE activity results in an accumulation of the neurotransmitter acetylcholine, and thereby overstimulation of the …

Safety and effectiveness of diroximel fumarate in relapsing forms of multiple sclerosis: a systematic review and meta-analysis

Multiple sclerosis (MS) is a chronic, immune-mediated disease characterized by inflammation of the central nervous system (CNS), demyelination, and axonal degeneration. It is estimated to affect more than 2.9 million people worldwide. The major …

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