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Multiple Sclerosis

Open Access Multiple Sclerosis Review

How could AI advance MS management?

AI models have been extensively applied to lesion segmentation and identifying biomarkers for multiple sclerosis. What other insights might they offer into pathogenesis, diagnosis, and prognosis?

Editor's Choice

Parental smoking linked to increased MS risk

04-07-2024 Multiple Sclerosis News

Selective exposure to parental smoking at a young age may differentially increase an individual’s risk for developing pediatric- and adult-onset multiple sclerosis.

Differentiating MOGAD

Myelin oligodendrocyte glycoprotein antibody disease is an antibody-mediated neuroinflammatory condition, which can mimic MS and NMOSD. What makes it distinct and how should you manage it?

Top questions on cladribine in MS

Open Access Multiple Sclerosis Review

Cladribine tablets are approved for relapsing multiple sclerosis, but patients may have many questions about switching to a short-course treatment. How should you answer them?

Early DMT reduces disability in pediatric MS

Children with multiple sclerosis have a reduced risk of disability if treated early with high-efficacy disease-modifying therapies. 

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Case Studies

Treating progressive multifocal leukoencephalopathy in MS

The first report of filgrastim being used to treat PML secondary to fingolimod in a patient with relapsing–remitting multiple sclerosis, resulting in a favourable response.

Biochemical hyperthyroidism caused by biotin

Open Access Hyperthyroidism Case Study

Biochemical hyperthyroidism in a patient with multiple sclerosis. Awareness of biotin use is key to avoiding misdiagnosis and inappropriate treatment as biotin can interfere with thyroid test results.

Webinar | 02-05-2024 | 17:30 (CEST)

Keynote webinar | Spotlight on sleep in brain health

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
Developed by: Springer Medicine

Current Reviews

De-escalation and Discontinuation of Disease-Modifying Therapies in Multiple Sclerosis

The field of multiple sclerosis (MS) has experienced enormous advances in the last 30 years, exemplified by the introduction of over 20 disease-modifying therapies (DMTs), which have been shown in large-scale clinical trials to reduce the …

Sex ratio and age of onset in AQP4 antibody-associated NMOSD: a review and meta-analysis

Aquaporin-4 (AQP4) antibody-associated neuromyelitis optica spectrum disorder (NMOSD) is an antibody-mediated autoimmune astrocytopathy that typically manifests as symptoms arising from inflammatory attacks of the optic nerves, diencephalon …

Adis summary of research: Matching‑adjusted indirect comparisons of diroximel fumarate, ponesimod, and teriflunomide for relapsing multiple sclerosis

Diroximel Fumarate Adis Summary of Research

Several oral disease-modifying therapies (DMTs) have been approved for the treatment of relapsing multiple sclerosis (MS), including diroximel fumarate, ponesimod and teriflunomide. Oral DMTs are more convenient than other MS therapies that …

Depression and anxiety in multiple sclerosis. Review of a fatal combination

Multiple Sclerosis Neurology and Preclinical Neurological Studies - Review Article

Depression and anxiety are the most frequent neuropsychiatric symptoms of multiple sclerosis (MS), an autoimmune-mediated demyelinating neurodegenerative disease. Their prevalence is 25–65% and 20–54%, respectively, often associated with chronic …

Alzheimer's Disease Independent Medical Education

Neuroimaging for Alzheimer’s disease: eLearning (Link opens in a new window)

Neuroimaging plays an increasingly critical role in clinical practice. PET Pearls is an interactive activity designed to improve your confidence and accuracy when interpreting imaging for early signs of cognitive impairment.

Supported by: Lilly

Developed by: Springer Healthcare IME

Further Reading

Causal relationship between multiple sclerosis and primary Sjögren’s syndrome: a two-sample mendelian randomization study

Open Access Primary Sjögren Syndrome Research

This study aims to investigate the causal relationship between primary Sjögren’s syndrome (SS) and multiple sclerosis (MS) using a two-sample Mendelian randomization (MR) analysis to provide insights into their common mechanisms and implications …

Digital outcome measures are associated with brain atrophy in patients with multiple sclerosis

Open Access Multiple Sclerosis Original Research

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease that necessitates continuous monitoring to make adequate treatment decisions [ 1 ]. In the present-day clinical practice, the main focus of MS care is on monitoring …

Microstructural characterization of multiple sclerosis lesion phenotypes using multiparametric longitudinal analysis

Open Access Multiple Sclerosis Original Research

The development of quantitative MRI (qMRI) techniques has enabled the characterization of microstructural tissue properties in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis [ 1 – 3 ] (MS), where conventional imaging …

ENTIMOS: Decision Support Tool Highlights Potential Impact of Non-intravenous Therapies for Multiple Sclerosis on Patient Care via Clinical Scenario Simulation

Open Access Multiple Sclerosis Original Research Article

The outlook for patients with multiple sclerosis (MS) evolved substantially since the first disease-modifying treatment (DMT) was introduced in the 1990s, as more efficacious DMTs that markedly reduce relapse rates and slow disability accumulation …