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01-09-2020 | Multiple Myeloma | Original Article

Long non-coding RNA CCAT2 as a potential serum biomarker for diagnosis and prognosis of multiple myeloma

Authors: Honglei Xu, Qingqing Yin, Xianjuan Shen, Shaoqing Ju

Published in: Annals of Hematology | Issue 9/2020

Abstract

Increasing knowledge of long non-coding RNAs (lncRNAs) has shown that they can be used as circulating tumor markers. Also, considerable evidences have revealed that lncRNAs have important roles in tumor diagnosis and prognosis. The lncRNA CCAT2 has manifested its carcinogenic effect in a variety of tumors, but the serum expression level and clinical value in multiple myeloma (MM) remain to be explored. In our study, the expression of lncRNA CCAT2 is upregulated in the serum and bone marrow of MM patients by using quantitative real-time polymerase chain reaction (qRT-PCR). The high expression level of CCAT2 in the serum of MM patients correlated with International Scoring System (ISS) stages, renal dysfunction, serum β₂-microglobulin (β₂-MG) concentration, and light chain (κ and λ) concentrations. Area under the curve (AUC) of CCAT2 in serum is 0.899. Besides, the sensitivity and specificity were 85.80% and 83%, respectively. Furthermore, combination of CCAT2, IgA, HGB, and β₂-MG significantly improved the MM diagnostic sensitivity and AUC. Here, our present investigation indicates that serum circulating CCAT2 may serve as a potential tumor marker for diagnosis and prognosis of MM.

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Title: Long non-coding RNA CCAT2 as a potential serum biomarker for diagnosis and prognosis of multiple myeloma
Authors: Honglei Xu
Qingqing Yin
Xianjuan Shen
Shaoqing Ju
Publication date: 01-09-2020
Publisher: Springer Berlin Heidelberg
Keywords: Multiple Myeloma
Biomarkers
Published in: Annals of Hematology / Issue 9/2020
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-020-04161-9

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