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Annals of Hematology
Published in: Annals of Hematology 9/2020

01-09-2020 | Mood Disorders | Original Article

Sleep disturbance in adults with sickle cell disease: relationships with executive and psychological functioning

Authors: Amanda Rhodes, Staci Martin, Pamela Wolters, Yessica Rodriguez, Mary Anne Toledo-Tamula, Kari Struemph, Courtney Fitzhugh, Matt Hsieh, John Tisdale

Published in: Annals of Hematology | Issue 9/2020

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Abstract

Sleep disturbance is common among children with sickle cell disease (SCD) and is related to neurocognitive difficulties. However, research on sleep disturbances and related variables among adults with SCD is extremely limited. The present study examined the relationship between sleep, executive functioning, and emotional functioning among 62 adults (29 females; M age = 32 years, SD = 7.79) with SCD preparing to undergo a stem cell transplant. Participants were administered a neurocognitive evaluation that included objective and subjective measures of executive functioning, and they completed PROMIS self-report measures of anxiety, depression, and pain intensity. Results showed that about 17% of participants endorsed clinically significant sleep disruptions, while 16.1% and 8% endorsed clinically significant symptoms of anxiety and depression, respectively. Sleep disturbance in these adults was not significantly correlated with objective or subjective measures of executive functioning. Moreover, anxiety, but not depression, was a significant mediator between self-reported sleep difficulties and both objective and subjective measures of executive functioning while controlling for pain intensity. Future research on sleep interventions will be essential for ameliorating the effects of sleep disturbance on executive functioning and anxiety among adults with SCD.
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Metadata
Title
Sleep disturbance in adults with sickle cell disease: relationships with executive and psychological functioning
Authors
Amanda Rhodes
Staci Martin
Pamela Wolters
Yessica Rodriguez
Mary Anne Toledo-Tamula
Kari Struemph
Courtney Fitzhugh
Matt Hsieh
John Tisdale
Publication date
01-09-2020
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 9/2020
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-020-04058-7

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