Issue 1/2016
Content (76 Articles)
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate
Elisa Belluzzi, Adriano Gonnelli, Maria-Daniela Cirnaru, Antonella Marte, Nicoletta Plotegher, Isabella Russo, Laura Civiero, Susanna Cogo, Maria Perèz Carrion, Cinzia Franchin, Giorgio Arrigoni, Mariano Beltramini, Luigi Bubacco, Franco Onofri, Giovanni Piccoli, Elisa Greggio
A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism
Li Zhong, Yong-Zhuang Xie, Tian-Tian Cao, Zongqi Wang, Tingting Wang, Xinxiu Li, Rui-Chi Shen, Huaxi Xu, Guojun Bu, Xiao-Fen Chen
Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease
Amanda Heslegrave, Wendy Heywood, Ross Paterson, Nadia Magdalinou, Johan Svensson, Per Johansson, Annika Öhrfelt, Kaj Blennow, John Hardy, Jonathan Schott, Kevin Mills, Henrik Zetterberg
The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer’s disease pathogenesis
Yoonhee Kim, Chaeyoung Kim, Sung Min Son, Hyundong Song, Hyun Seok Hong, Sun-ho Han, Inhee Mook-Jung
Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression
Mickael Audrain, Romain Fol, Patrick Dutar, Brigitte Potier, Jean-Marie Billard, Julien Flament, Sandro Alves, Marie-Anne Burlot, Gaelle Dufayet-Chaffaud, Alexis-Pierre Bemelmans, Julien Valette, Philippe Hantraye, Nicole Déglon, Nathalie Cartier, Jérome Braudeau
Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson’s disease
Mária Baranyi, Pier Francesca Porceddu, Flóra Gölöncsér, Szabina Kulcsár, Lilla Otrokocsi, Ágnes Kittel, Annalisa Pinna, Lucia Frau, Paul B. Huleatt, Mui-Ling Khoo, Christina L. L. Chai, Petra Dunkel, Peter Mátyus, Micaela Morelli, Beáta Sperlágh
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
Nour K. Majbour, Nishant N. Vaikath, Karin D. van Dijk, Mustafa T. Ardah, Shiji Varghese, Louise B. Vesterager, Liliana P. Montezinho, Stephen Poole, Bared Safieh-Garabedian, Takahiko Tokuda, Charlotte E. Teunissen, Henk W. Berendse, Wilma D. J. van de Berg, Omar M. A. El-Agnaf
Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis
Su Min Lim, Won Jun Choi, Ki-Wook Oh, Yuanchao Xue, Ji Young Choi, Sung Hoon Kim, Minyeop Nahm, Young-Eun Kim, Jinhyuk Lee, Min-Young Noh, Seungbok Lee, Sejin Hwang, Chang-Seok Ki, Xiang-Dong Fu, Seung Hyun Kim
Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells
Matthew R. Reynolds, Itender Singh, Tej D. Azad, Brandon B. Holmes, Phillip B. Verghese, Hans H. Dietrich, Marc Diamond, Guojun Bu, Byung Hee Han, Gregory J. Zipfel
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Sighild Lemarchant, Yuriy Pomeshchik, Iurii Kidin, Virve Kärkkäinen, Piia Valonen, Sarka Lehtonen, Gundars Goldsteins, Tarja Malm, Katja Kanninen, Jari Koistinaho
A Fluorescent Oligothiophene-Bis-Triazine ligand interacts with PrP fibrils and detects SDS-resistant oligomers in human prion diseases
Thibaut Imberdis, Adeline Ayrolles-Torro, Alysson Duarte Rodrigues, Joan Torrent, Maria Teresa Alvarez-Martinez, Gabor G. Kovacs, Jean-Michel Verdier, Mike Robitzer, Véronique Perrier
Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson’s disease
Affif Zaccaria, Ali Bouamrani, Stephan Chabardès, Michèle El Atifi, Eric Seigneuret, Johannes A. Lobrinus, Michel Dubois-Dauphin, François Berger, Pierre R. Burkhard
Direct α-synuclein promoter transactivation by the tumor suppressor p53
Eric Duplan, Cécile Giordano, Frédéric Checler, Cristine Alves da Costa
Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury
Hong Fan, Kun Zhang, Lequn Shan, Fang Kuang, Kun Chen, Keqing Zhu, Heng Ma, Gong Ju, Ya-Zhou Wang
Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Sighild Lemarchant, Yuriy Pomeshchik, Iurii Kidin, Virve Kärkkäinen, Piia Valonen, Sarka Lehtonen, Gundars Goldsteins, Tarja Malm, Katja Kanninen, Jari Koistinaho
Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
Erica Barini, Odetta Antico, Yingjun Zhao, Francesco Asta, Valter Tucci, Tiziano Catelani, Roberto Marotta, Huaxi Xu, Laura Gasparini
Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models
Matteo Cornaglia, Gopalan Krishnamani, Laurent Mouchiroud, Vincenzo Sorrentino, Thomas Lehnert, Johan Auwerx, Martin A. M. Gijs
Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo
Emily Sempou, Emiliano Biasini, Alejandro Pinzón-Olejua, David A. Harris, Edward Málaga-Trillo
Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
Caroline Schönherr, Jessica Bien, Simone Isbert, Rielana Wichert, Johannes Prox, Hermann Altmeppen, Sathish Kumar, Jochen Walter, Stefan F. Lichtenthaler, Sascha Weggen, Markus Glatzel, Christoph Becker-Pauly, Claus U. Pietrzik
Erratum to: Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay
Wendy E. Heywood, Daniela Galimberti, Emily Bliss, Ernestas Sirka, Ross W. Paterson, Nadia K. Magdalinou, Miryam Carecchio, Emma Reid, Amanda Heslegrave, Chiara Fenoglio, Elio Scarpini, Jonathan M. Schott, Nick C. Fox, John Hardy, Kailash P. Bhatia, Simon Heales, Neil J. Sebire, Henrik Zetterberg, Kevin Mills
Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis
Raffaele Ferrari, Paola Forabosco, Jana Vandrovcova, Juan A. Botía, Sebastian Guelfi, Jason D. Warren, Parastoo Momeni, Michael E. Weale, Mina Ryten, John Hardy
Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer’s disease
Véréna Landel, Pascal Millet, Kévin Baranger, Béatrice Loriod, François Féron
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
Marina Saresella, Francesca La Rosa, Federica Piancone, Martina Zoppis, Ivana Marventano, Elena Calabrese, Veronica Rainone, Raffaello Nemni, Roberta Mancuso, Mario Clerici
C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury
Sean M. Silverman, Byung-Jin Kim, Garreth R. Howell, Joselyn Miller, Simon W. M. John, Robert J. Wordinger, Abbot F. Clark
Pioglitazone ameliorates the phenotype of a novel Parkinson’s disease mouse model by reducing neuroinflammation
Milena Pinto, Nadee Nissanka, Susana Peralta, Roberta Brambilla, Francisca Diaz, Carlos T. Moraes
Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma
Pete A. Williams, James R. Tribble, Keating W. Pepper, Stephen D. Cross, B Paul Morgan, James E. Morgan, Simon W. M. John, Gareth R. Howell
Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons
Evgeny D. Nekrasov, Vladimir A. Vigont, Sergey A. Klyushnikov, Olga S. Lebedeva, Ekaterina M. Vassina, Alexandra N. Bogomazova, Ilya V. Chestkov, Tatiana A. Semashko, Elena Kiseleva, Lyubov A. Suldina, Pavel A. Bobrovsky, Olga A. Zimina, Maria A. Ryazantseva, Anton Yu. Skopin, Sergey N. Illarioshkin, Elena V. Kaznacheyeva, Maria A. Lagarkova, Sergey L. Kiselev
MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease
Yan Zhou, Ming Lu, Ren-Hong Du, Chen Qiao, Chun-Yi Jiang, Ke-Zhong Zhang, Jian-Hua Ding, Gang Hu
Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson’s Disease
Bruno A. Benitez, Albert A. Davis, Sheng Chih Jin, Laura Ibanez, Sara Ortega-Cubero, Pau Pastor, Jiyoon Choi, Breanna Cooper, Joel S. Perlmutter, Carlos Cruchaga
In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells
Byung-Jin Kim, Sean M. Silverman, Yang Liu, Robert J. Wordinger, Iok-Hou Pang, Abbot F. Clark
Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain
Philipp A. Jaeger, Kurt M. Lucin, Markus Britschgi, Badri Vardarajan, Ruo-Pan Huang, Elizabeth D. Kirby, Rachelle Abbey, Bradley F. Boeve, Adam L. Boxer, Lindsay A. Farrer, NiCole Finch, Neill R. Graff-Radford, Elizabeth Head, Matan Hofree, Ruochun Huang, Hudson Johns, Anna Karydas, David S. Knopman, Andrey Loboda, Eliezer Masliah, Ramya Narasimhan, Ronald C. Petersen, Alexei Podtelezhnikov, Suraj Pradhan, Rosa Rademakers, Chung-Huan Sun, Steven G. Younkin, Bruce L. Miller, Trey Ideker, Tony Wyss-Coray
A seeding based cellular assay of tauopathy
Yin Xu, Heidi Martini-Stoica, Hui Zheng
Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model
Ghulam Jeelani Pir, Bikash Choudhary, Eckhard Mandelkow, Eva-Maria Mandelkow
Ex vivo imaging of active caspase 3 by a FRET-based molecular probe demonstrates the cellular dynamics and localization of the protease in cerebellar granule cells and its regulation by the apoptosis-inhibiting protein survivin
Laura Lossi, Carolina Cocito, Silvia Alasia, Adalberto Merighi
A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease
Jia Luo, Sue H. Lee, Lawren VandeVrede, Zhihui Qin, Manel Ben Aissa, John Larson, Andrew F. Teich, Ottavio Arancio, Yohan D’Souza, Ahmed Elharram, Kevin Koster, Leon M. Tai, Mary Jo LaDu, Brian M. Bennett, Gregory R. J. Thatcher
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia
Carolina Alquezar, Irene G. Salado, Ana de la Encarnación, Daniel I. Pérez, Fermín Moreno, Carmen Gil, Adolfo López de Munain, Ana Martínez, Ángeles Martín-Requero
Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan
Yuan Fu, Jing Zhao, Yuka Atagi, Henrietta M. Nielsen, Chia-Chen Liu, Honghua Zheng, Mitsuru Shinohara, Takahisa Kanekiyo, Guojun Bu
Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
Sofia Söllvander, Elisabeth Nikitidou, Robin Brolin, Linda Söderberg, Dag Sehlin, Lars Lannfelt, Anna Erlandsson
Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy
Juan Yang, Song Li, Xi-Biao He, Cheng Cheng, Weidong Le
Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease
Jia Luo, Sue H. Lee, Lawren VandeVrede, Zhihui Qin, Manel Ben Aissa, John Larson, Andrew F. Teich, Ottavio Arancio, Yohan D’Souza, Ahmed Elharram, Kevin Koster, Leon M. Tai, Mary Jo LaDu, Brian M. Bennett, Gregory R. J. Thatcher
Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR
Xavier Gallart-Palau, Aida Serra, Siu Kwan Sze
Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain
Philipp A. Jaeger, Kurt M. Lucin, Markus Britschgi, Badri Vardarajan, Ruo-Pan Huang, Elizabeth D. Kirby, Rachelle Abbey, Bradley F. Boeve, Adam L. Boxer, Lindsay A. Farrer, NiCole Finch, Neill R. Graff-Radford, Elizabeth Head, Matan Hofree, Ruochun Huang, Hudson Johns, Anna Karydas, David S. Knopman, Andrey Loboda, Eliezer Masliah, Ramya Narasimhan, Ronald C. Petersen, Alexei Podtelezhnikov, Suraj Pradhan, Rosa Rademakers, Chung-Huan Sun, Steven G. Younkin, Bruce L. Miller, Trey Ideker, Tony Wyss-Coray
Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons
Sarah Bellouze, Gilbert Baillat, Dorothée Buttigieg, Pierre de la Grange, Catherine Rabouille, Georg Haase
Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice
Claire S. Harwell, Michael P. Coleman
Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo
Jonathan R. Fisher, Clare E. Wallace, Danielle L. Tripoli, Yvette I. Sheline, John R. Cirrito
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
Christopher J. Holler, Georgia Taylor, Zachary T. McEachin, Qiudong Deng, William J. Watkins, Kathryn Hudson, Charles A. Easley, William T. Hu, Chadwick M. Hales, Wilfried Rossoll, Gary J. Bassell, Thomas Kukar
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment
Peter Dongmin Sohn, Tara E. Tracy, Hye-In Son, Yungui Zhou, Renata E. P. Leite, Bruce L. Miller, William W. Seeley, Lea T. Grinberg, Li Gan
Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges
Holger Cynis, Jeffrey L. Frost, Helen Crehan, Cynthia A. Lemere
Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe
Daniel M. Mason, Negin Nouraei, Deepti B. Pant, Kristin M. Miner, Daniel F. Hutchison, Kelvin C. Luk, John F. Stolz, Rehana K. Leak
Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer’s disease
Syed Faraz Kazim, Khalid Iqbal
Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice
Lan-yan Lin, Jing Zhang, Xiao-man Dai, Nai-an Xiao, Xi-lin Wu, Zhen Wei, Wen-ting Fang, Yuan-gui Zhu, Xiao-chun Chen
Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease
Ramon Velazquez, Darren M. Shaw, Antonella Caccamo, Salvatore Oddo
Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune encephalomyelitis
Reiner Schneider, Barbara Koop, Friederike Schröter, Jason Cline, Jens Ingwersen, Carsten Berndt, Hans-Peter Hartung, Orhan Aktas, Tim Prozorovski
IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrier
Min Jung Lee, So Jin Bing, Jonghee Choi, Minhee Jang, Gihyun Lee, Hyunkyoung Lee, Byung Soo Chang, Youngheun Jee, Sung Joong Lee, Ik-Hyun Cho
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)
Jaekwang Kim, Fabienne C. Fiesel, Krystal C. Belmonte, Roman Hudec, Wang-Xia Wang, Chaeyoung Kim, Peter T. Nelson, Wolfdieter Springer, Jungsu Kim
ZNStress: a high-throughput drug screening protocol for identification of compounds modulating neuronal stress in the transgenic mutant sod1G93R zebrafish model of amyotrophic lateral sclerosis
Alexander McGown, Dame Pamela J. Shaw, Tennore Ramesh
Erratum to: Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe
Daniel M. Mason, Negin Nouraei, Deepti B. Pant, Kristin M. Miner, Daniel F. Hutchison, Kelvin C. Luk, John F. Stolz, Rehana K. Leak
Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins
Sandro Alves, Thibaut Marais, Maria-Grazia Biferi, Denis Furling, Martina Marinello, Khalid El Hachimi, Nathalie Cartier, Merle Ruberg, Giovanni Stevanin, Alexis Brice, Martine Barkats, Annie Sittler
Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts
Pierre De Rossi, Virginie Buggia-Prévot, Benjamin L. L. Clayton, Jared B. Vasquez, Carson van Sanford, Robert J. Andrew, Ruben Lesnick, Alexandra Botté, Carole Deyts, Someya Salem, Eshaan Rao, Richard C. Rice, Angèle Parent, Satyabrata Kar, Brian Popko, Peter Pytel, Steven Estus, Gopal Thinakaran
The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment
Jianmin Chen, Yanping Chen, Graham Vail, Heiman Chow, Yang Zhang, Lauren Louie, Jiali Li, Ronald P. Hart, Mark R. Plummer, Karl Herrup
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein
Natalie Landeck, Hélène Hall, Mustafa T. Ardah, Nour K. Majbour, Omar M. A. El-Agnaf, Glenda Halliday, Deniz Kirik
Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy
Erin E. Congdon, Yan Lin, Hameetha B. Rajamohamedsait, Dov B. Shamir, Senthilkumar Krishnaswamy, Wajitha J. Rajamohamedsait, Suhail Rasool, Veronica Gonzalez, Josien Levenga, Jiaping Gu, Charles Hoeffer, Einar M. Sigurdsson
A Christianson syndrome-linked deletion mutation (∆287ES288) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death
Alina Ilie, Andy Y. L. Gao, Jonathan Reid, Annie Boucher, Cassandra McEwan, Hervé Barrière, Gergely L. Lukacs, R. Anne McKinney, John Orlowski
Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice
Carmen Agustín-Pavón, Michal Mielcarek, Mireia Garriga-Canut, Mark Isalan
No diurnal variation of classical and candidate biomarkers of Alzheimer’s disease in CSF
Claudia Cicognola, Davide Chiasserini, Paolo Eusebi, Ulf Andreasson, Hugo Vanderstichele, Henrik Zetterberg, Lucilla Parnetti, Kaj Blennow
Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer’s disease
Aitana Sogorb-Esteve, María-Salud García-Ayllón, Juan Fortea, Raquel Sánchez-Valle, Alberto Lleó, José-Luis Molinuevo, Javier Sáez-Valero
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons
Martina Pigoni, Johanna Wanngren, Peer-Hendrik Kuhn, Kathryn M. Munro, Jenny M. Gunnersen, Hiroshi Takeshima, Regina Feederle, Iryna Voytyuk, Bart De Strooper, Mikail D. Levasseur, Brian J. Hrupka, Stephan A. Müller, Stefan F. Lichtenthaler
Spinal cord injury induces astroglial conversion towards neuronal lineage
Harun Najib Noristani, Jean Charles Sabourin, Hassan Boukhaddaoui, Emilie Chan-Seng, Yannick Nicolas Gerber, Florence Evelyne Perrin
Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling
Christine Altmann, Verica Vasic, Stefanie Hardt, Juliana Heidler, Annett Häussler, Ilka Wittig, Mirko H. H. Schmidt, Irmgard Tegeder
Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb- and paraquat-induced model of Parkinson’s disease
Ashutosh Kumar, Douglas Ganini, Ronald P. Mason
Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice
Roy Chun-Laam Ng, On-Yin Cheng, Min Jian, Jason Shing-Cheong Kwan, Philip Wing-Lok Ho, Kenneth King-Yip Cheng, Patrick Ka Kit Yeung, Lena Lei Zhou, Ruby Lai-Chong Hoo, Sookja Kim Chung, Aimin Xu, Karen Siu-Ling. Lam, Koon Ho Chan
Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains
Li Ma, Mariet Allen, Nobutaka Sakae, Nilufer Ertekin-Taner, Neill R. Graff-Radford, Dennis W. Dickson, Steven G. Younkin, Daniel Sevlever
LRRK2 at the interface of autophagosomes, endosomes and lysosomes
Dorien A. Roosen, Mark R. Cookson
Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation
Thiyagaragan M. Achariyar, Baoman Li, Weiguo Peng, Philip B. Verghese, Yang Shi, Evan McConnell, Abdellatif Benraiss, Tristan Kasper, Wei Song, Takahiro Takano, David M. Holtzman, Maiken Nedergaard, Rashid Deane
3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”
Se Hoon Choi, Young Hye Kim, Luisa Quinti, Rudolph E. Tanzi, Doo Yeon Kim
ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models
Mitchell S. Wold, Junghyun Lim, Véronik Lachance, Zhiqiang Deng, Zhenyu Yue