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The Journal of Headache and Pain

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Open Access 01-12-2022 | Migraine | Research article

Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system

Authors: Judit Rosta, Máté Tóth, Nadine Friedrich, Péter Sántha, Gábor Jancsó, Mária Dux

Published in: The Journal of Headache and Pain | Issue 1/2022

Abstract

Background

Clinical observations suggest that hyperinsulinemia and insulin resistance can be associated with migraine headache. In the present study we examined the effect of insulin on transient receptor potential vanilloid 1 (TRPV1) receptor-dependent meningeal nociceptor functions in rats.

Methods

The effects of insulin on the TRPV1 receptor stimulation-induced release of calcitonin gene related peptide (CGRP) from trigeminal afferents and changes in meningeal blood flow were studied. Colocalization of the insulin receptor, the TRPV1 receptor and CGRP was also analyzed in trigeminal ganglion neurons.

Results

Insulin induced release of CGRP from meningeal afferents and consequent increases in dural blood flow through the activation of TRPV1 receptors of trigeminal afferents. Insulin sensitized both neural and vascular TRPV1 receptors making them more susceptible to the receptor agonist capsaicin. Immunohistochemistry revealed colocalization of the insulin receptor with the TRPV1 receptor and CGRP in a significant proportion of trigeminal ganglion neurons.

Conclusions

Insulin may activate or sensitize meningeal nociceptors that may lead to enhanced headache susceptibility in persons with increased plasma insulin concentration.

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Title: Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system
Authors: Judit Rosta
Máté Tóth
Nadine Friedrich
Péter Sántha
Gábor Jancsó
Mária Dux
Publication date: 01-12-2022
Publisher: Springer Milan
Keywords: Migraine
Insulins
Capsaicin
Headache
Insulins
Published in: The Journal of Headache and Pain / Issue 1/2022
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-021-01380-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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