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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2022

Open Access 01-12-2022 | Magnetic Resonance Imaging | Research

Cerebral perfusion variance in new daily persistent headache and chronic migraine: an arterial spin-labeled MR imaging study

Authors: Xiaoyan Bai, Wei Wang, Xueyan Zhang, Zhangxuan Hu, Yingkui Zhang, Zhiye Li, Xue Zhang, Ziyu Yuan, Hefei Tang, Yaqing Zhang, Xueying Yu, Peng Zhang, Yonggang Wang, Binbin Sui

Published in: The Journal of Headache and Pain | Issue 1/2022

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Abstract

Background and purpose

New daily persistent headache (NDPH) and chronic migraine (CM) are two different types of headaches that might involve vascular dysregulation. There is still a lack of clarity about altered brain perfusion in NDPH and CM. This study aimed to investigate the cerebral perfusion variances of NDPH and CM using multi-delay pseudo-continuous arterial spin-labeled magnetic resonance imaging (pCASL-MRI).

Methods

Fifteen patients with NDPH, 18 patients with CM, and 15 age- and sex-matched healthy controls (HCs) were included. All participants underwent 3D multi-delay pCASL-MRI to obtain cerebral perfusion data, including arrival-time-corrected cerebral blood flow (CBF) and arterial cerebral blood volume (aCBV). The automated anatomical labeling atlas 3 (AAL3) was used to parcellate 170 brain regions. The CBF and aCBV values in each brain region were compared among the three groups. Correlation analyses between cerebral perfusion parameters and clinical variables were performed.

Results

Compared with HC participants, patients with NDPH were found to have decreased CBF and aCBV values in multiple regions in the right hemisphere, including the right posterior orbital gyrus (OFCpost.R), right middle occipital gyrus (MOG.R), and ventral anterior nucleus of right thalamus (tVA.R), while patients with CM showed increased CBF and aCBV values presenting in the ventral lateral nucleus of left thalamus (tVL.L) and right thalamus (tVL.R) compared with HCs (all p < 0.05). In patients with NDPH, after age and sex adjustment, the increased aCBV values of IFGorb. R were positively correlated with GAD-7 scores; and the increased CBF and aCBV values of tVA.R were positively correlated with disease duration.

Conclusion

The multi-delay pCASL technique can detect cerebral perfusion variation in patients with NDPH and CM. The cerebral perfusion changes may suggest different variations between NDPH and CM, which might provide hemodynamic evidence of these two types of primary headaches.
Appendix
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Metadata
Title
Cerebral perfusion variance in new daily persistent headache and chronic migraine: an arterial spin-labeled MR imaging study
Authors
Xiaoyan Bai
Wei Wang
Xueyan Zhang
Zhangxuan Hu
Yingkui Zhang
Zhiye Li
Xue Zhang
Ziyu Yuan
Hefei Tang
Yaqing Zhang
Xueying Yu
Peng Zhang
Yonggang Wang
Binbin Sui
Publication date
01-12-2022
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2022
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-022-01532-7

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