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Published in: The Journal of Headache and Pain 4/2012

Open Access 01-06-2012 | Original

Metabolic syndrome and insulin resistance in migraine

Authors: Sanjeev K. Bhoi, Jayantee Kalita, Usha K. Misra

Published in: The Journal of Headache and Pain | Issue 4/2012

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Abstract

Metabolic syndrome is associated with migraine but there is no study comparing the characteristics of migraine with and without metabolic syndrome from Southeast Asia. This study was therefore undertaken to compare the clinical characteristics of migraine in patients with and without metabolic syndrome and insulin resistance. 135 consecutive patients with migraine diagnosed on the basis of International Headache Society criteria were subjected to clinical evaluation as per fixed protocol. Headache severity, frequency and functional disability were recorded. Metabolic syndrome was diagnosed as per National Cholesterol Education Programme: Adult Treatment Panel III and International Diabetic Federation criteria. Insulin resistance was calculated by homeostases model assessment. Their age ranged between 14 and 61 years and 108 were females. Metabolic syndrome was present in 31.9% patients and only 13 were obese. Insulin resistance was present in 11.1%. Metabolic syndrome was correlated with age, gender, number of triggers, years of headache and duration of migraine attacks. Insulin resistance correlated with duration of migraine attacks. From this study, it can be concluded that metabolic syndrome was present in 31.9% of the migraineurs which was mainly in elderly who had longer duration of headache and multiple triggers.
Literature
1.
go back to reference Robbins MS, Lipton RB (2010) The epidemiology of primary headache disorder. Semin Neurol 30:107–119, 20352581, 10.1055/s-0030-1249220CrossRefPubMed Robbins MS, Lipton RB (2010) The epidemiology of primary headache disorder. Semin Neurol 30:107–119, 20352581, 10.1055/s-0030-1249220CrossRefPubMed
2.
go back to reference Brennum J, Brinck T, Schriver L et al (1996) Sumatriptan has no clinically relevant effect in the treatment of episodic tension type headache. Eur J Neurol 3:23–28, 10.1111/j.1468-1331.1996.tb00184.xCrossRef Brennum J, Brinck T, Schriver L et al (1996) Sumatriptan has no clinically relevant effect in the treatment of episodic tension type headache. Eur J Neurol 3:23–28, 10.1111/j.1468-1331.1996.tb00184.xCrossRef
3.
go back to reference Stang PE, Carson AP, Rose KM et al (2005) Headache, cerebrovascular symptoms, and stroke: the atherosclerosis risk in communities study. Neurology 64:1573–1577, 15883318, 10.1212/01.WNL.0000158326.31368.04, 1:STN:280:DC%2BD2M3ksFWntw%3D%3DCrossRefPubMed Stang PE, Carson AP, Rose KM et al (2005) Headache, cerebrovascular symptoms, and stroke: the atherosclerosis risk in communities study. Neurology 64:1573–1577, 15883318, 10.1212/01.WNL.0000158326.31368.04, 1:STN:280:DC%2BD2M3ksFWntw%3D%3DCrossRefPubMed
4.
go back to reference Lipton RB, Stewart WF, Cady R et al (2000) Wolfe Award. Sumatriptan for the range of headaches in migraine sufferers: results of the Spectrum Study. Headache 40:783–791, 11135021, 10.1046/j.1526-4610.2000.00143.x, 1:STN:280:DC%2BD3M7jvFaltg%3D%3DCrossRefPubMed Lipton RB, Stewart WF, Cady R et al (2000) Wolfe Award. Sumatriptan for the range of headaches in migraine sufferers: results of the Spectrum Study. Headache 40:783–791, 11135021, 10.1046/j.1526-4610.2000.00143.x, 1:STN:280:DC%2BD3M7jvFaltg%3D%3DCrossRefPubMed
5.
go back to reference Lj Stovner, Hagen K, Jensen R et al (2007) The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 27:193–210, 10.1111/j.1468-2982.2007.01288.xCrossRef Lj Stovner, Hagen K, Jensen R et al (2007) The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 27:193–210, 10.1111/j.1468-2982.2007.01288.xCrossRef
6.
go back to reference Sakai F, Igarashi H (1997) Prevalence of migraine in Japan: a nationwide survey. Cephalalgia 17:15–22, 9051330, 10.1046/j.1468-2982.1997.1701015.x, 1:STN:280:DyaK2s3gtlOmug%3D%3DCrossRefPubMed Sakai F, Igarashi H (1997) Prevalence of migraine in Japan: a nationwide survey. Cephalalgia 17:15–22, 9051330, 10.1046/j.1468-2982.1997.1701015.x, 1:STN:280:DyaK2s3gtlOmug%3D%3DCrossRefPubMed
7.
go back to reference Horev A, Wirguin I, Lantsberg L, Ifergane G (2005) A high incidence of migraine with aura among morbidly obese women. Headache 5:936–938, 10.1111/j.1526-4610.2005.05162.xCrossRef Horev A, Wirguin I, Lantsberg L, Ifergane G (2005) A high incidence of migraine with aura among morbidly obese women. Headache 5:936–938, 10.1111/j.1526-4610.2005.05162.xCrossRef
8.
go back to reference Rainero I, Limone P, Ferrero M et al (2005) Insulin sensitivity is impaired in patients with migraine. Cephalalgia 25:593–597, 16033384, 10.1111/j.1468-2982.2005.00928.x, 1:STN:280:DC%2BD2MznsF2jtA%3D%3DCrossRefPubMed Rainero I, Limone P, Ferrero M et al (2005) Insulin sensitivity is impaired in patients with migraine. Cephalalgia 25:593–597, 16033384, 10.1111/j.1468-2982.2005.00928.x, 1:STN:280:DC%2BD2MznsF2jtA%3D%3DCrossRefPubMed
9.
go back to reference Guldiken B, Guldiken S, Taskiran B et al (2009) Migraine in metabolic syndrome. Neurologist 15:55–58, 19276782, 10.1097/NRL.0b013e31817781b6CrossRefPubMed Guldiken B, Guldiken S, Taskiran B et al (2009) Migraine in metabolic syndrome. Neurologist 15:55–58, 19276782, 10.1097/NRL.0b013e31817781b6CrossRefPubMed
10.
go back to reference Bigal E, Liberman JN, Lipton RB (2006) Obesity and migraine: a population study. Neurology 66:545–550, 16354886, 10.1212/01.wnl.0000197218.05284.82CrossRefPubMed Bigal E, Liberman JN, Lipton RB (2006) Obesity and migraine: a population study. Neurology 66:545–550, 16354886, 10.1212/01.wnl.0000197218.05284.82CrossRefPubMed
11.
go back to reference Mattsson P (2007) Migraine headache and obesity in women aged 40–74 years: a population-based study. Cephalalgia 27:877–880, 17635528, 10.1111/j.1468-2982.2007.01360.x, 1:STN:280:DC%2BD2svkt1Wgtg%3D%3DCrossRefPubMed Mattsson P (2007) Migraine headache and obesity in women aged 40–74 years: a population-based study. Cephalalgia 27:877–880, 17635528, 10.1111/j.1468-2982.2007.01360.x, 1:STN:280:DC%2BD2svkt1Wgtg%3D%3DCrossRefPubMed
12.
go back to reference Takeshima T (2009) Metabolic syndrome and prevention of migraine headache. Brain Nerve 61:1143–1153, 19882941PubMed Takeshima T (2009) Metabolic syndrome and prevention of migraine headache. Brain Nerve 61:1143–1153, 19882941PubMed
13.
go back to reference Guldiken B, Guldiken S, Demir M et al (2008) Insulin resistance and high sensitivity C-reactive protein in migraine. Can J Neurol Sci 35:448–451, 18973061CrossRefPubMed Guldiken B, Guldiken S, Demir M et al (2008) Insulin resistance and high sensitivity C-reactive protein in migraine. Can J Neurol Sci 35:448–451, 18973061CrossRefPubMed
14.
go back to reference Cavestro C, Rosatello A, Micca GM et al (2007) Insulin metabolism is altered in migraineurs: a new pathogenic mechanism for migraine? Headache 47:1436–1442, 18052953, 10.1111/j.1526-4610.2007.00719.xCrossRefPubMed Cavestro C, Rosatello A, Micca GM et al (2007) Insulin metabolism is altered in migraineurs: a new pathogenic mechanism for migraine? Headache 47:1436–1442, 18052953, 10.1111/j.1526-4610.2007.00719.xCrossRefPubMed
15.
go back to reference Rao NS, Pearce J (1971) Hypothalamic-pituitary-adrenal axis studies in migraine with special reference to insulin sensitivity. Brain 94:289–298, 4936865, 10.1093/brain/94.2.289, 1:STN:280:DyaE3M3ptVWlsg%3D%3DCrossRefPubMed Rao NS, Pearce J (1971) Hypothalamic-pituitary-adrenal axis studies in migraine with special reference to insulin sensitivity. Brain 94:289–298, 4936865, 10.1093/brain/94.2.289, 1:STN:280:DyaE3M3ptVWlsg%3D%3DCrossRefPubMed
16.
go back to reference Headache Classification Sub-Committee of the International Headache Society (2004) International classification of headache disorders, 2nd edition. Cephalalgia 24:1–160 Headache Classification Sub-Committee of the International Headache Society (2004) International classification of headache disorders, 2nd edition. Cephalalgia 24:1–160
17.
go back to reference National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106:3143–3421 National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106:3143–3421
18.
go back to reference Alberti KG, Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group (2005) The metabolic syndrome–a new worldwide definition. Lancet 366:1059–1062, 16182882, 10.1016/S0140-6736(05)67402-8CrossRefPubMed Alberti KG, Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group (2005) The metabolic syndrome–a new worldwide definition. Lancet 366:1059–1062, 16182882, 10.1016/S0140-6736(05)67402-8CrossRefPubMed
19.
go back to reference Mattews DR, Hosker JP, Rudenski AS et al (1985) Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419, 10.1007/BF00280883CrossRef Mattews DR, Hosker JP, Rudenski AS et al (1985) Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419, 10.1007/BF00280883CrossRef
20.
go back to reference Esteghamati A, Ashraf H, Khalilzadeh O et al (2010) Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR) for the diagnosis of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007). Nutr Metab (Lond) 7:26, 10.1186/1743-7075-7-26CrossRef Esteghamati A, Ashraf H, Khalilzadeh O et al (2010) Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR) for the diagnosis of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007). Nutr Metab (Lond) 7:26, 10.1186/1743-7075-7-26CrossRef
21.
go back to reference Schele R, Ahlborg B, Ekbom K (1978) Physical characteristics and allergic history in young men with migraine and other headaches. Headache 1:80–86, 10.1111/j.1526-4610.1978.hed1802080.xCrossRef Schele R, Ahlborg B, Ekbom K (1978) Physical characteristics and allergic history in young men with migraine and other headaches. Headache 1:80–86, 10.1111/j.1526-4610.1978.hed1802080.xCrossRef
22.
go back to reference Ford ES, Li C, Pearson WS, Zhao G, Strine TW, Mokdad AH (2008) Body mass index and headaches: findings from a national sample of US adults. Cephalalgia 28:1270–1276, 18727641, 10.1111/j.1468-2982.2008.01671.x, 1:STN:280:DC%2BD1cjmslWntw%3D%3DCrossRefPubMed Ford ES, Li C, Pearson WS, Zhao G, Strine TW, Mokdad AH (2008) Body mass index and headaches: findings from a national sample of US adults. Cephalalgia 28:1270–1276, 18727641, 10.1111/j.1468-2982.2008.01671.x, 1:STN:280:DC%2BD1cjmslWntw%3D%3DCrossRefPubMed
23.
go back to reference Vega GL (2010) Is intra-abdominal obesity a unique risk factor for metabolic syndrome in non-diabetics? Indian J Med Res 131:603–605, 20516529PubMed Vega GL (2010) Is intra-abdominal obesity a unique risk factor for metabolic syndrome in non-diabetics? Indian J Med Res 131:603–605, 20516529PubMed
24.
go back to reference Winter AC, Berger K, Buring JE, Kurth T (2009) Body mass index, migraine, migraine frequency, and migraine features in women. Cephalalgia 29:269–278, 19143772, 10.1111/j.1468-2982.2008.01716.x, 1:STN:280:DC%2BD1M%2Fnt1Sksg%3D%3DPubMedCentralCrossRefPubMed Winter AC, Berger K, Buring JE, Kurth T (2009) Body mass index, migraine, migraine frequency, and migraine features in women. Cephalalgia 29:269–278, 19143772, 10.1111/j.1468-2982.2008.01716.x, 1:STN:280:DC%2BD1M%2Fnt1Sksg%3D%3DPubMedCentralCrossRefPubMed
25.
go back to reference Bic Z, Blix GG, Hopp HP, Leslie FM (1998) In search of the ideal treatment for migraine headache. Med Hypotheses 50:1–7, 9488175, 10.1016/S0306-9877(98)90170-0, 1:STN:280:DyaK1c7kslCquw%3D%3DCrossRefPubMed Bic Z, Blix GG, Hopp HP, Leslie FM (1998) In search of the ideal treatment for migraine headache. Med Hypotheses 50:1–7, 9488175, 10.1016/S0306-9877(98)90170-0, 1:STN:280:DyaK1c7kslCquw%3D%3DCrossRefPubMed
26.
go back to reference Scher AI, Terwindt GM, Picavet HS et al (2005) Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64:614–620, 15728281, 10.1212/01.WNL.0000151857.43225.49, 1:STN:280:DC%2BD2M%2FpvVyjsg%3D%3DCrossRefPubMed Scher AI, Terwindt GM, Picavet HS et al (2005) Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64:614–620, 15728281, 10.1212/01.WNL.0000151857.43225.49, 1:STN:280:DC%2BD2M%2FpvVyjsg%3D%3DCrossRefPubMed
27.
go back to reference Yadav RK, Kalita J, Misra UK (2010) A study of triggers of migraine in India. Pain Med 11:44–47, 19793343, 10.1111/j.1526-4637.2009.00725.xCrossRefPubMed Yadav RK, Kalita J, Misra UK (2010) A study of triggers of migraine in India. Pain Med 11:44–47, 19793343, 10.1111/j.1526-4637.2009.00725.xCrossRefPubMed
28.
go back to reference Masters JB, Mortimer MJ, Hay KM (1986) Glucose and diet in fasting migraineurs. Headache 26:243–247, 10.1111/j.1526-4610.1986.hed2605243.xCrossRef Masters JB, Mortimer MJ, Hay KM (1986) Glucose and diet in fasting migraineurs. Headache 26:243–247, 10.1111/j.1526-4610.1986.hed2605243.xCrossRef
29.
go back to reference Dexter JD, Roberts J, Byer JA (1978) The five hour glucose tolerance test and effect of low sucrose diet in migraine. Headache 18:91–94, 649385, 10.1111/j.1526-4610.1978.hed1802091.x, 1:STN:280:DyaE1c7ntFSguw%3D%3DCrossRefPubMed Dexter JD, Roberts J, Byer JA (1978) The five hour glucose tolerance test and effect of low sucrose diet in migraine. Headache 18:91–94, 649385, 10.1111/j.1526-4610.1978.hed1802091.x, 1:STN:280:DyaE1c7ntFSguw%3D%3DCrossRefPubMed
30.
go back to reference Split W, Szydlowska M (1997) Headaches in non insulin-dependent diabetes mellitus. Funct Neurol 12:327–332, 9503195, 1:STN:280:DyaK1c7mtl2htw%3D%3DPubMed Split W, Szydlowska M (1997) Headaches in non insulin-dependent diabetes mellitus. Funct Neurol 12:327–332, 9503195, 1:STN:280:DyaK1c7mtl2htw%3D%3DPubMed
31.
go back to reference Yadav S, Boddula R, Genitta G et al (2008) Prevalence and risk factors of pre-hypertension and hypertension in an affluent north Indian population. Indian J Med Res 128:712–720, 19246794, 1:STN:280:DC%2BD1M7ntVOmsg%3D%3DPubMed Yadav S, Boddula R, Genitta G et al (2008) Prevalence and risk factors of pre-hypertension and hypertension in an affluent north Indian population. Indian J Med Res 128:712–720, 19246794, 1:STN:280:DC%2BD1M7ntVOmsg%3D%3DPubMed
Metadata
Title
Metabolic syndrome and insulin resistance in migraine
Authors
Sanjeev K. Bhoi
Jayantee Kalita
Usha K. Misra
Publication date
01-06-2012
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 4/2012
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1007/s10194-012-0416-y

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