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Published in: Current Pain and Headache Reports 4/2024

16-02-2024 | Migraine | Chronic Daily Headache (S-J Wang and S-P Chen, Section Editors)

Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review

Authors: Po-Kuan Yeh, Yu-Chin An, Kuo-Sheng Hung, Fu-Chi Yang

Published in: Current Pain and Headache Reports | Issue 4/2024

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Abstract

Purpose of Review

In this narrative review, we aim to summarize recent insights into the complex interplay between environmental and genetic factors affecting the etiology, development, and progression of chronic migraine (CM).

Recent Findings

Environmental factors such as stress, sleep dysfunction, fasting, hormonal changes, weather patterns, dietary compounds, and sensory stimuli are critical triggers that can contribute to the evolution of episodic migraine into CM. These triggers are particularly influential in genetically predisposed individuals. Concurrently, genome-wide association studies (GWAS) have revealed over 100 genetic loci linked to migraine, emphasizing a significant genetic basis for migraine susceptibility.

Summary

In CM, environmental and genetic factors are of equal importance and contribute to the pathophysiology of the condition. Understanding the bidirectional interactions between these elements is crucial for advancing therapeutic approaches and preventive strategies. This balanced perspective encourages continued research into the complex gene-environment nexus to improve our understanding and management of CM.
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Metadata
Title
Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review
Authors
Po-Kuan Yeh
Yu-Chin An
Kuo-Sheng Hung
Fu-Chi Yang
Publication date
16-02-2024
Publisher
Springer US
Keyword
Migraine
Published in
Current Pain and Headache Reports / Issue 4/2024
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-024-01228-4

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