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Open Access 01-10-2010 | Rapid Communication

Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine

Authors: Giovanna Gentile, Marina Borro, Noemi Lala, Serena Missori, Maurizio Simmaco, Paolo Martelletti

Published in: The Journal of Headache and Pain | Issue 5/2010

Abstract

Migraine is a common type of headache and its most severe attacks are usually treated with triptans, the efficacy of which is extremely variable. Several SNPs in genes involved in metabolism and target mechanisms of triptans have been described. To define an association between genetic profile and triptan response, we classified a migrainous population on the basis of triptan response and characterized it for polymorphisms in the genes coding for monoamine oxidase A, G protein β3 and the cytochrome CYP1A2. Analysis of the association between genotypic and allelic frequencies of the analyzed SNPs and the grade of response to triptan administration showed a significant correlation for MAOA uVNTR polymorphism. Further stratification of patients in abuser and non-abuser groups revealed a significant association with triptan overuse and, within the abusers, with drug response to the CYP1A2*1F variant.

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Title: Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine
Authors: Giovanna Gentile
Marina Borro
Noemi Lala
Serena Missori
Maurizio Simmaco
Paolo Martelletti
Publication date: 01-10-2010
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 5/2010
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1007/s10194-010-0241-0

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