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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2023

Open Access 01-12-2023 | Metastasis | Review

The critical role of platelet in cancer progression and metastasis

Authors: Lin Zhou, Zhe Zhang, Yizhou Tian, Zefei Li, Zhongliang Liu, Sibo Zhu

Published in: European Journal of Medical Research | Issue 1/2023

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Abstract

Platelets play a crucial role in cancer blood metastasis. Various cancer-related factors such as Toll-like receptors (TLRs), adenosine diphosphate (ADP) or extracellular matrix (ECM) can activate these small particles that function in hemostasis and thrombosis. Moreover, platelets induce Epithelial Mesenchymal Transition (EMT) to promote cancer progression and invasiveness. The activated platelets protect circulating tumor cells from immune surveillance and anoikis. They also mediate tumor cell arrest, extravasation and angiogenesis in distant organs through direct or indirect modulation, creating a metastatic microenvironment. This review summarizes the recent advances and progress of mechanisms in platelet activation and its interaction with cancer cells in metastasis.
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Metadata
Title
The critical role of platelet in cancer progression and metastasis
Authors
Lin Zhou
Zhe Zhang
Yizhou Tian
Zefei Li
Zhongliang Liu
Sibo Zhu
Publication date
01-12-2023
Publisher
BioMed Central
Keyword
Metastasis
Published in
European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-023-01342-w

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