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European Journal of Medical Research

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Open Access 01-12-2023 | Osteoporosis | Research

A nomogram for predicting the risk of new vertebral compression fracture after percutaneous kyphoplasty

Authors: Aiqi Zhang, Yichen Lin, Mingxiang Kong, Jiahao Chen, Wei Gao, Jiajun Fan, Junjie Wang, Zhe Chen

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Background

New vertebral compression fractures (NVCFs) are common adverse events in percutaneous kyphoplasty (PKP). The present study aimed to investigate the risk factors for NVCFs in patients after PKP and to construct a nomogram for the prediction of the risk of re-fracture.

Methods

We retrospectively analyzed the medical records of patients after PKP surgery between January 2017 and December 2020. Patients were divided into an NVCF group (n = 225) and a control group (n = 94) based on the presence or absence of NVCFs, respectively, at follow-up within 2 years after surgery. Lasso regression was used to screen for risk factors for re-fracture. Based on the results, a Lasso-logistic regression model was developed, and its prediction performance was evaluated using receiver operating characteristic curves, calibration, and decision curve analysis. The model was visualized, and a nomogram was constructed.

Results

A total of eight potential predictors were obtained from Lasso screening. Advanced age, low body mass index, low bone mineral density, lack of anti-osteoporosis treatment, low preoperative vertebral body height, vertebral body height recovery ≥ 2, cement leakage, and shape D (lack of simultaneous contact of bone cement with the upper and lower plates) were included in the logistic regression model.

Conclusions

A nomogram for predicting postoperative NVCF in PKP was developed and validated. This model can be used for rational assessment of the magnitude of the risk of developing NVCFs after PKP, and can help orthopedic surgeons make clinical decisions aimed at reducing the occurrence of NVCFs.

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Title: A nomogram for predicting the risk of new vertebral compression fracture after percutaneous kyphoplasty
Authors: Aiqi Zhang
Yichen Lin
Mingxiang Kong
Jiahao Chen
Wei Gao
Jiajun Fan
Junjie Wang
Zhe Chen
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Osteoporosis
Osteoporosis
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01235-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A nomogram for predicting the risk of new vertebral compression fracture after percutaneous kyphoplasty

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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