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Open Access 01-12-2020 | Metastasis | Research

Effect of preoperative jaundice on long-term prognosis of gallbladder carcinoma with radical resection

Authors: Xin-wei Yang, Jun-yi Chen, Zhi-jian Wen, Yu-long Li, Fei-yu Wang, Liang Li, Jue Yang, Ping-hua Yang, Bao-hua Zhang, Feng Shen

Published in: World Journal of Surgical Oncology | Issue 1/2020

Abstract

Purposes

This study was designed to evaluate the effect of preoperative jaundice on long-term prognosis of gallbladder carcinoma (GBC) after radical resection (R0).

Methods

A total of 267 GBC patients who underwent R0 resection from January 2004 to December 2014 were enrolled, including 54 patients with preoperative jaundice and 213 patients without jaundice. The clinicopathological parameters between the two groups were compared, and the correlation between preoperative jaundice and the long-term prognosis was furtherly analyzed.

Results

Unilateral and multivariate analyses of 267 GBC patients showed that the depth of tumor invasion (pT stage), lymphatic metastasis, and hepatic invasion were independent prognostic factors. The univariate and multivariate analysis of 54 GBC patients with preoperative jaundice showed that only pT stage was an independent factor for prognosis. Furthermore, the intraoperative blood transfusion and pT stage were significant different between long-term survival (survive for more than 3 years) and those who died within 3 years (P < 0.05).

Conclusion

Preoperative jaundice was not the independent factor resulting in the poor long-term prognosis of gallbladder carcinoma after R0 resection. The pT stage was the only long-term prognostic factor in all GBC patients regardless of preoperative jaundice.

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Title: Effect of preoperative jaundice on long-term prognosis of gallbladder carcinoma with radical resection
Authors: Xin-wei Yang
Jun-yi Chen
Zhi-jian Wen
Yu-long Li
Fei-yu Wang
Liang Li
Jue Yang
Ping-hua Yang
Bao-hua Zhang
Feng Shen
Publication date: 01-12-2020
Publisher: BioMed Central
Keyword: Metastasis
Published in: World Journal of Surgical Oncology / Issue 1/2020
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-020-02015-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of preoperative jaundice on long-term prognosis of gallbladder carcinoma with radical resection

Abstract

Purposes

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purposes

Methods

Results

Conclusion

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