Top

Published in:

01-05-2013 | General Gynecology

Meta-analysis of the efficacy and safety of the application of adjuvant material in the repair of anterior vaginal wall prolapsed

Authors: Hu Min, Hong Li, Li Bingshu, Cheng Yanxiang, Chen Lu, Sun Qing, Zhu Xuejiao, Wu Wenying, Wu Debin, Hong Shasha, Ding Wenjuan, Min Jie, Zhang Xiaohong, Guo Wenjun, Chen Jianhua, Liu Qian, Liu Yuling

Published in: Archives of Gynecology and Obstetrics | Issue 5/2013

Abstract

Introduction

This study is a meta-analysis of the efficacy and safety of the application of adjuvant material in the repair of anterior vaginal wall prolapse and a sub-category analysis of the use of nonabsorbable synthetic mesh, biological graft and absorbable synthetic mesh.

Method

Pubmed, Embase and Ovid databases were searched for published randomized controlled trials from 1980 to February 2012 on the treatment of anterior vaginal wall prolapse with adjuvant materials. A comprehensive meta-analysis applying Revman5.1 analysis software was performed.

Results

A total of 20 randomized controlled trials including 2,313 participants were recognized. The result showed that repair with adjuvant materials was better and more effective; nevertheless, use of adjuvant materials resulted in longer duration of surgery and more peri-operative bleeding when compared with the control group, but no significant differences were observed between the two groups regarding visceral injury, postoperative pain, urinary tract infection rate, new stress incontinence and new dyspareunia.

Conclusion

Adjuvant material is worthy of clinical popularization, especially the biological graft type because of its lower anatomy failure rate and no difference in safety compared with the control group. However, exposure to adjuvant materials and erosion rate are high, which are the most important aspects to be improved.

Olsen AL, Smith VJ, Bergstrom JO, Colling JC, Clark AL (1997) Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 89:501–506PubMedCrossRef

Fialkow MF, Newton KM, Lentz GM, Weiss NS (2008) Lifetime risk of surgical management for pelvic organ prolapse or urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 19:437–440PubMedCrossRef

Subak LL, Waetjen LE, van den Eeden S, Thom DH, Vittinghoff E, Brown JS (2001) Cost of pelvic organ prolapse surgery in the United States. Obstet Gynecol 98:646–651PubMedCrossRef

Novara G, Artibani W (2005) Surgery for pelvic organ prolapse: current status and future perspectives. Curr Opin Urol 15:256–262PubMedCrossRef

Davila GW (2006) Introduction to the 2005 IUGA grafts roundtable. Int Urogynecol J 17(Suppl 1):S4–S5CrossRef

Griffis K, Hale DS (2005) Grafts in pelvic reconstructive surgery. Clin Obstet Gynecol 48(3):713–723PubMedCrossRef

Winters JC, Fitzgerald MP, Barber MD (2006) The use of synthetic mesh in female pelvic reconstructive surgery. BJU Int 98(Suppl 1):70–6 (discussion 77)

Julian TM (1996) The efficacy of Marlex mesh in the repair of severe, recurrent vaginal prolapse of the anterior midvaginal wall. Am J Obstet Gynecol 175:1472–1475PubMedCrossRef

Foon R, Toozs-Hobson P, Latthe PM (2008) Adjuvant materials in anterior vaginal wall prolapse surgery: a systematic review of effectiveness and complications. Int Urogynecol J 19:1697–1706

10.

Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a metaanalysis. Stat Med 21:1539–1558PubMedCrossRef

11.

Altman D, Väyrynen T, Engh ME, et al. Nordic Transvaginal Mesh Group (2011) Anterior colporrhaphy versus transvaginal mesh for pelvic-organ prolapse. N Engl J Med 364(19):1826–1836

12.

Gandhi S, Goldberg RP, Kwon C et al (2005) A prospective randomized trial using solvent dehydrated fascia lata for the prevention of recurrent anterior vaginal wall prolapse. Am J Obstet Gynecol 192:1649–1654PubMedCrossRef

13.

Guerette NL, Peterson TV, Aguirre OA et al (2009) Anterior repair with or without collagen matrix reinforcement: a randomized controlled trial. Obstet Gynecol 114(1):59–65PubMed

14.

Hiltunen R, Nieminen K, Takala T, Heinonen PK et al (2007) Low-weight polypropylene mesh for anterior vaginal wall prolapse: a randomized controlled trial. Obstet Gynecol 110(2 II):455–462

15.

Hviid U, Hviid TV, Rudnicki M (2010) Porcine skin collagen implants for anterior vaginal wall prolapse: a randomised prospective controlled study. Int Urogynecol J 21(5):529–534PubMedCrossRef

16.

Menefee SA, Dyer KY, Lukacz ES et al (2011) Colporrhaphy compared with mesh or graft-reinforced vaginal paravaginal repair for anterior vaginal wall prolapse: a randomized controlled trial. Obstet Gynecol 118(6):1337–1344PubMedCrossRef

17.

Meschia M, Pifarotti P, Bernasconi F et al (2007) Porcine skin collagen implants to prevent anterior vaginal wall prolapse recurrence: a multicenter, randomized study. J Urol 177:192–195PubMedCrossRef

18.

Nguyen JN, Burchette RJ (2008) Outcome after anterior vaginal prolapse repair: a randomized controlled trial. Obstet Gynecol 111(4):891–898PubMedCrossRef

19.

Nieminen K, Hiltunen R, Takala T et al (2010) Outcomes after anterior vaginal wall repair with mesh: a randomized, controlled trial with a 3 year follow-up. Am J Obstet Gynecol 203(3):235.e1–235.e8

20.

Feldner PC Jr, Castro RA, Cipolotti LA et al (2010) Anterior vaginal wall prolapse: a randomized controlled trial of SIS graft versus traditional colporrhaphy. Int Urogynecol J 21:1057–1063

21.

Sand PK, Koduri S, Lobel RW et al (2001) Prospective randomized trial of polyglactin 910 mesh to prevent recurrence of cystoceles and rectoceles. Am J Obstet Gynecol 184:1357–1362PubMedCrossRef

22.

Sivaslioglu AA, Unlubilgin E, Dolen I (2008) A randomized comparison of polypropylene mesh surgery with site-specific surgery in the treatment of cystocele. Int Urogynecol J Pelvic Floor Dysfunct 19(4):467–471

23.

Vollebregt A, Fischer K, Gietelink D et al (2011) Primary surgical repair of anterior vaginal prolapse: a randomised trial comparing anatomical and functional outcome between anterior colporrhaphy and trocar-guided transobturator anterior mesh. BJOG Int J Obstet Gynaecol 118(12):1518–1527CrossRef

24.

Weber AM, Walters MD, Piedmonte MR et al (2001) Anterior colporrhaphy: a randomized trial of three surgical techniques. Am J Obstet Gynecol 185:1299–1304PubMedCrossRef

25.

Del Roy C (2011) A randomized controlled trial study, to compare colporrhaphy versus NAZCA TC™, macroporous polypropylene mesh, in surgical treatment to greater anterior vaginal prolapse. Int Urogynecol J Pelvic Floor Dysfunct 22(Suppl 2):S860

26.

Duggan P, Barry C (2011) Anterior compartment prolapse: Short term results and quality of life in women randomised to mesh or traditional repair. Int Urogynecol J Pelvic Floor Dysfunct 22(Suppl 2):S894–S895

27.

Dyer K, Nguyen J, Simsiman A et al (2010) The optimal anterior repair study (OARS): a triple arm randomized double blinded clinical trial of standard colporrhaphy versus paravaginal repair with xenograft or synthetic mesh. J Pelvic Med Surg 16(5 Suppl):S68–S69

28.

Rudnicki M, Teleman P, Laurikainen E et al (2011) The use of avaulta plus(R) for anterior repair, a multicenter randomised prospective controlled study. Int Urogynecol J 22(Suppl 2):S197–S1768

29.

Ali S, Han HC, Lee LC (2006) A prospective randomized trial using Gynemesh PS for the repair of anterior vaginal wall prolapse. Int Urogynecol J Pelvic Floor Dysfunct 17:S221

30.

Al-Nazer MA, Ismail WA, Gomma IA (2007) Comparative study between anterior colporrhaphy versus vaginal wall repair with mesh for management of anterior vaginal wall prolapse. Int Urogynecol J Pelvic Floor Dysfunct 18:S49–S50CrossRef

31.

Weber AM, Abrams P, Brubaker L et al (2001) The standardization of terminology for researchers in female pelvic floor disorders. Int Urogynecol J Pelvic Floor Dysfunct 12(3):178–186PubMedCrossRef

32.

Bump RC, Mattiasson A, Bo K, Brubaker LP, DeLancey JO, Klarskov P et al (1996) The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 175:10–17PubMedCrossRef

33.

Swift S, Woodman P, O’Boyle A, Kahn M, Valley M, Bland D et al (2005) Pelvic Organ Support Study (POSST): the distribution, clinical definition, and epidemiologic condition of pelvic organ support defects. Am J Obstet Gynecol 192:795–806PubMedCrossRef

34.

Barber MD, Brubaker L, Nygaard I et al (2009) Pelvic floor disorders network: defining success after surgery for pelvic organ prolapse. Obstet Gynecol 114(3):600–609PubMedCrossRef

35.

Lee U, Raz S (2011) Emerging concepts for pelvic organ prolapse surgery: what is cure? Curr Urol Rep 12(1):62–67PubMedCrossRef

36.

Haylen BT, Freeman RM, Swift SE et al (2011) An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint terminology and classification of the complications related directly to the insertion of prostheses (meshes, implants, tapes) and grafts in female pelvic floor surgery. Neurourol Urodyn 30(1):2–12PubMedCrossRef

37.

Stedman’s medical dictionary. Lippincott, Williams and Wilkins, Baltimore

38.

Collinet P, Belot F, Debodinance P et al (2006) Transvaginal mesh technique for pelvic organ prolapse repair: mesh exposure management and risk factors. Int Urogynecol J Pelvic Floor Dysfunct 17:315–320PubMedCrossRef

39.

Abed H, Rahn DD, Lowenstein L, Balk EM, Clemons JL, Rogers RG, For the Systematic Review Group of the Society of Gynecologic Surgeons (2011) Incidence and management of graft erosion, wound granulation, and dyspareunia following vaginal prolapse repair with graft materials: a systematic review. Int Urogynecol J Pelvic Floor Dysfunct. doi:10.1007/s00192-011-1384-5

40.

Milani R, Salvatore S, SoligoM Pifarotti P, MeschiaM CorteseM (2005) Functional and anatomical, outcome of anterior and posterior vaginal prolapse repair with prolene mesh. BJOG 112:107–111PubMedCrossRef

41.

Creighton SM, Stanton SL (1991) The surgical management of vaginal vault prolapse. BJOG 98:1150–1154CrossRef

42.

Deval B, Rafii A, Azria E, Darai E, Levardon M (2003) Vaginal mesh erosion 7 years after a sacral colpopexy. Acta Obstet Gynecol Scand 82(7):674–675PubMedCrossRef

43.

Simonds RJ, Homberg SD, Hurwitz RL (1992) Transmission of human immunodeficiency virus type 1 from seronegative organ tissue donor. N Eng J Med 326:726–730CrossRef

44.

Claerhout F, Deprest J, Zheng F, Konstantinovic M, Lagae P, De Ridder D (2003) Longterm evaluation of the tissue response and mechanical properties of two collagen based and polypropylene implants in a rabbit model for abdominal wall repair. Neurourol Urodyn 22:516–517

45.

Fitzgerald MP, Mollenhauer J, Bitterman P, Brubaker L (1999) Functional failure of fascia lata allografts. Am J Obstet Gynecol 181:1339–1346PubMedCrossRef

46.

Brubaker L (2005) Controversies and uncertainties: abdominal versus vaginal surgery for pelvic organ prolapse. Am J Obstet Gynecol 192:690–693PubMedCrossRef

Title: Meta-analysis of the efficacy and safety of the application of adjuvant material in the repair of anterior vaginal wall prolapsed
Authors: Hu Min
Hong Li
Li Bingshu
Cheng Yanxiang
Chen Lu
Sun Qing
Zhu Xuejiao
Wu Wenying
Wu Debin
Hong Shasha
Ding Wenjuan
Min Jie
Zhang Xiaohong
Guo Wenjun
Chen Jianhua
Liu Qian
Liu Yuling
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 5/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2626-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Meta-analysis of the efficacy and safety of the application of adjuvant material in the repair of anterior vaginal wall prolapsed

Abstract

Introduction

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Method

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 5/2013

Prostaglandin E2 alteration in contraceptive consumers: as a risk factor for inflammatory diseases

2-Methoxyoestradiol levels and placental catechol-O-methyltransferase expression in patients with late-onset preeclampsia

Effects of acupuncture for initiation of labor: a double-blind randomized sham-controlled trial

Effect of a gonadotropin-releasing hormone analogue on cyclophosphamide-induced ovarian toxicity in adult mice

Comparison the effects of oxytocin and methylergonovine in elective caesarean section under spinal anesthesia

Comparison between 2D ultrasonography and magnetic resonance imaging for assessing brain and spine parameters in fetuses with spina bifida