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01-12-2018 | Review

Mechanisms of neuropathogenesis in HIV and HCV: similarities, differences, and unknowns

Authors: Ameer Abutaleb, Sarah Kattakuzhy, Shyam Kottilil, Erin O’Connor, Eleanor Wilson

Published in: Journal of NeuroVirology | Issue 6/2018

Abstract

HIV and hepatitis C virus (HCV) have both been associated with cognitive impairment. Combination antiretroviral therapy (cART) has dramatically changed the nature of cognitive impairment in HIV-infected persons, while the role of direct-acting antivirals (DAA) in neurocognition of HCV-infected individuals remains unclear. Also, whether HIV and HCV interact to promote neurocognitive decline or whether they each contribute an individual effect continues to be an open question. In this work, we review the virally mediated mechanisms of HIV- and HCV-mediated neuropathogenesis, with an emphasis on the role of dual infection, and discuss observed changes with HIV viral suppression and HCV functional cure on neurocognitive impairments.

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Title: Mechanisms of neuropathogenesis in HIV and HCV: similarities, differences, and unknowns
Authors: Ameer Abutaleb
Sarah Kattakuzhy
Shyam Kottilil
Erin O’Connor
Eleanor Wilson
Publication date: 01-12-2018
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 6/2018
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-018-0678-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Mechanisms of neuropathogenesis in HIV and HCV: similarities, differences, and unknowns

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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