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01-06-2018

Neurocognitive impairment with hepatitis C and HIV co-infection in Southern Brazil

Authors: Sérgio Monteiro de Almeida, Ana Paula de Pereira, Maria Lucia Alves Pedroso, Clea E. Ribeiro, Indianara Rotta, Bin Tang, Anya Umlauf, Donald Franklin, Rowan G. Saloner, Maria Geny Ribas Batista, Scott Letendre, Robert K. Heaton, Ronald J. Ellis, Mariana Cherner, the HNRC Group

Published in: Journal of NeuroVirology | Issue 3/2018

Abstract

Although cognitive impairment has been well documented in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) mono-infections, research on neurocognitive effects is limited in the context of HIV/HCV co-infection. The aims of this study were to explore the interplay between HIV and HCV infections in the expression of neurocognitive impairment (NCI), and to examine the differences in test performance between HIV/HCV co-infected and HIV or HCV mono-infected patients. A total of 128 participants from Southern Brazil underwent a comprehensive neuropsychological (NP) battery comprising 18 tests. Participants were grouped according to their serological status: HCV mono-infected (n = 20), HIV mono-infected (n = 48), HIV/HCV co-infected (n = 12), and HIV−/HCV-uninfected controls (n = 48). The frequencies of HIV subtypes B and C between the HIV mono-infected and HIV/HCV co-infected groups were comparable. There was greater prevalence of neuropsychological impairment among all three infection groups compared with the uninfected control group, but no statistically significant differences among mono- and co-infected groups were found. HCV infection was associated with cognitive deficits, independently of liver dysfunction. HCV infection did not show an additive effect on neurocognitive function among HIV+. NCI was independent of HCV RNA on peripheral blood, CSF, and hepatic injury. While we did not find additive global effect, in the present study, there was some evidence of additive HIV/HCV co-infection effects in speed of information processing, executive function, and verbal fluency domains when comparing the co-infected group with the other three groups. NP impairment was not dependent on HCV subtypes.

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Abrantes J, Torres DS, Mello CEB (2013) Patients with hepatitis C infection and normal liver function: an evaluation of cognitive function. Postgrad Med J 89:433–439CrossRefPubMed

Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M et al (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69:1789–1799CrossRefPubMed

Blackstone K, Moore DJ, Franklin DR et al (2012) Defining neurocognitive impairment in HIV: deficita scores versus clinical ratings. Clin Neuropsychol:1–15

Brasil, Ministério da Saúde (2016) Programa Nacional de DST/AIDS. http://www.aids.gov.br/assistencia/manualdst/item12.htm.

Cacciarelli TV, Martinez OM, Gish RG, Villanueva JC, Krams SM (1996) Immunoregulatory cytokines in chronic hepatitis C virus infection: pre- and posttreatment with interferon alfa. Hepatology 24:6–9CrossRefPubMed

Carey CL, Woods SP, Rippeth JD, Gonzalez R, Moore DJ, Marcotte TD et al (2004a) Initial validation of a screening battery for the detection of HIV-associated cognitive impairment. Clin Neuropsychol 18:234–248CrossRefPubMed

Carey CL, Woods SP, Gonzalez R, Conover E, Marcotte TD, Grant I et al (2004b) Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection. J Clin Exp Neuropsychol 26:307–319CrossRefPubMed

Cattie JE, Letendre SL, Woods SP, Barakat F, Perry W, Cherner M et al (2014) Persistent neurocognitive decline in a clinic sample of hepatitis C virus-infected persons receiving interferon and ribavirin treatment. J Neuro-Oncol 20:561–570

Cherner M, Letendre S, Heaton RK, Durelle J, Marquie-Beck J, Gragg B (2005) Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine. Neurology 64:1343–1347CrossRefPubMed

Chou R, Wasson N (2013) Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review. Ann Intern Med 158:807–820CrossRefPubMed

Ciccarelli N, Fabbiani M, Grima P, Falasca K, Tana M, Baldonero E et al (2013) Comparison of cognitive performance in HIV or HCV mono-infected and HIV–HCV co-infected patients. Infection 41:1103–1109CrossRefPubMed

Clifford DB, Evans SR, Yang Y, Gulick RM (2005) The neuropsychological and neurological impact of hepatitis C virus co-infection in HIV-infected subjects. AIDS 19(Suppl 3):S64–S71CrossRefPubMed

Clifford DB, Vaida F, Kao YT, Franklin DR, Letendre SL, Collier AC et al (2015) Absence of neurocognitive effect of hepatitis C infection in HIV-coinfected people. Neurology 84:241–250CrossRefPubMedPubMedCentral

Cohen RA, de la Monte S, Gongvatana A, Ombao H, Gonzalez B, Devlin KN et al (2011) Plasma cytokine concentrations associated with HIV/hepatitis C coinfection are related to attention, executive and psychomotor functioning. J Neuroimmunol 233:204–210CrossRefPubMed

Cysique LA, Jin H, Franklin DR Jr, Morgan EE, Shi C, the HNRC Group (2007) Neurobehavioral effects of HIV-1 infection in China and the United States: a pilot study. J Int Neuropsychol Soc 13:781–790PubMedPubMedCentral

de Almeida SM, Ribeiro CE, de Pereira AP, Badiee J, Cherner M, Smith D et al (2013) Neurocognitive impairment in HIV-1 clade C- versus B-infected individuals in Southern Brazil. J Neurovirol 19:550–556CrossRefPubMedPubMedCentral

Forton DM, Allsop JM, Main J, Foster GR, Thomas HC, Taylor-Robinson SD (2001) Evidence for a cerebral effect of the hepatitis C virus. Lancet 358:38–39CrossRefPubMed

Ghate M, Mehendale S, Meyer R, Umlauf A, Deutsch R, Kamat R et al (2015) The effects of antiretroviral treatment initiation on cognition in HIV-infected individuals with advanced disease in Pune, India. J Neurovirol 21:391–398CrossRefPubMedPubMedCentral

Grant I (2008) Neurocognitive disturbances in HIV. Int Rev Psychiatry 20:33–47CrossRefPubMed

Heaton RK, Miller SW, Taylor MJ, Grant I (2004) Revised comprehensive norms for an expanded Halstead-Reitan battery: demographically adjusted neuropsychological norms for African American and Caucasian adults. Psychological Assessment esources, Inc.; Lutz.

Heaton RK, Clifford DB, Franklin DR, Woods SP, Ake C, Vaida F et al (2010) HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 75:2087–2096CrossRefPubMedPubMedCentral

Heaton RK, Franklin DR, Deutsch R, Letendre S, Ellis RJ, Casaletto K et al (2015) Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study. Clin Infect Dis 60:473–480CrossRefPubMed

Hilsabeck RC, Perry W, Hassanein TI (2002) Neuropsychological impairment in patients with chronic hepatitis C. Hepatology 35:440–446CrossRefPubMed

Hilsabeck RC, Hassanein TI, Carlson MD, Ziegler EA, Perry W (2003) Cognitive functioning and psychiatric symptomatology in patients with chronic hepatitis C. J Int Neuropsychol Soc 9:847–854CrossRefPubMed

Hilsabeck RC, Castellon SA, Hinkin CH (2005) Neuropsychological aspects of coinfection with HIV and hepatitis C virus. Clin Infect Dis 41(Suppl. 1):S38–S44CrossRefPubMed

Hinkin CH, Castellon SA, Levine AJ, Barclay TR, Singer EJ (2008) Neurocognition in individuals coinfected with HIV and hepatitis C. J Addict Dis 27:11–17CrossRefPubMedPubMedCentral

Huckans M, Seelye A, Parcel T, Mull L, Woodhouse J, Bjornson D et al (2009) The cognitive effects of hepatitis C in the presence and absence of a history of substance use disorder. J Int Neuropsychol Soc 15:69–82CrossRefPubMedPubMedCentral

Kanmogne GD, Kuate CT, Cysique LA, Fonsah JY, Eta S, Doh R et al (2010) HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon. BMC Neurol 10:60CrossRefPubMedPubMedCentral

Letendre SL, Cherner M, Ellis RJ, Marquie-Beck J, Gragg B, Marcotte T et al (2005) The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease. AIDS 19:S72–S78CrossRefPubMed

Lin ZH, Xin YN, Dong QJ, Wang Q, Jiang XJ, Zhan SH et al (2011) Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis: an updated meta-analysis. Hepatology 53:726–736CrossRefPubMed

McAndrews MP, Farcnik K, Carlen P, Damyanovich A, Mrkonjic M, Jones S (2005) Prevalence and significance of neurocognitive dysfunction in hepatitis C in the absence of correlated risk factors. Hepatology 41:801–808CrossRefPubMed

Murray J, Fishman SL, Ryan E, Eng FJ, Walewski JL, Branch AD (2008) Clinicopathologic correlates of hepatitis C virus in brain: a pilot study. J Neuro-Oncol 14:17–27

Perry W, Hilsabeck RC, Hassanein TI (2008) Cognitive dysfunction in chronic hepatitis C: a review. Dig Dis Sci 53:307–321CrossRefPubMed

Posada C, Morgan EE, Moore DJ, Woods SP, Letendre SL, Grant I (2009) Neurocognitive effects of the hepatitis C virus. Curr Hepatitis Rep 8:18–26CrossRef

Puccioni-Sohler M, Rosadas C, Cabral-Castro MJ (2013) Neurological complications in dengue infection: a review for clinical practice. Arq Neuropsiquiatr 71:667–671CrossRefPubMed

Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R (1973) Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60:646–649CrossRefPubMed

Quarantini LC, Miranda-Scippa A, Batista-Neves S, Powell VB, Abreu N, Abreu KC et al (2009) A neuropsychological study comparing patients infected with HCV and HBV without psychiatric comorbidities. J Med Virol 81:1184–1188CrossRefPubMed

Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L (2013) Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PLoS One 8:e55776CrossRefPubMedPubMedCentral

Richardson JL, Nowicki M, Danley K, Martin EM, Cohen MH, Gonzalez R et al (2005) Neuropsychological functioning in a cohort of HIV- and hepatitis C virus-infected women. AIDS 19:1659–1667CrossRefPubMed

Royal W III, Cherner M, Carr J, Habib AG, Akomolafe A, Abimiku A et al (2012) Clinical features and preliminary studies of virological correlates of neurocognitive impairment among HIV-infected individuals in Nigeria. J Neurovirol 18:191–199CrossRefPubMedPubMedCentral

Schouten J, Cinque P, Gisslen M, Reiss P, Portegies P (2011) HIV-1 infection and cognitive impairment in the cART-era: a review. AIDS 25:561–575CrossRefPubMed

Senzolo M, Schiff S, D’Aloisio CM, Crivellin C, Cholongitas E, Burra P et al (2011) Neuropsychological alterations in hepatitis C infection: the role of inflammation. World J Gastroenterol 17:3369–3374CrossRefPubMedPubMedCentral

Solomon T (2004) Flavivirus encephalitis. N Engl J Med 351:370–378CrossRefPubMed

Sterling RK, Lissen E, Clumeck N, Clumeck N, Sola R, Correa MC et al (2006) APRICOT Clinical Investigators. Development of a simple noninvasive index to predict significant fibrosis patients with HIV/HCV co-infection. Hepatology 43:1317–1325CrossRefPubMed

Sun B, Abadjian L, Rempel H, Monto A, Pulliam L (2013) Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. J Acquir Immune Defic Syndr 62:190–196CrossRefPubMedPubMedCentral

van de Beek D, Brouwer MC (2017) CNS infections in 2016: 2016, the year of Zika virus. Nat Rev Neurol 13:69–70CrossRefPubMed

Wai CT, Greenson JK, Fontana RJ, Kalbfleisch JD, Marrero JA, Conjeevaram HS et al (2003) A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology 38:518–526CrossRefPubMed

Weissenborn K, Krause J, Bokemeyer M, Hecker H, Schuler A, Ennen JC et al (2004) Hepatitis C virus infection affects the brain-evidence from psychometric studies and magnetic resonance spectroscopy. J Hepatol 41:845–851CrossRefPubMed

Weissenborn K, Bokemeyer M, Krause J, Ennen J, Ahl B (2005) Neurological and neuropsychiatric syndromes associated with liver disease. AIDS 19:S93–S98CrossRefPubMed

Wilkinson J, Radkpwski M, Laskus T (2009) Hepatitis C virus neuroinvasion: identification of infected cells. J Virol 83:1312–1319CrossRefPubMed

Wolff FH, Fuchs SC, Barcellos NNT, Alencastro PR, Ikeda MLR, Brandão ABM et al (2010) Co-infection by hepatitis C virus in HIV-infected patients in Southern Brazil: genotype distribution and clinical correlates. PLoS One 5:e10494CrossRefPubMedPubMedCentral

Woods SP, Moore DJ, Weber E, Grant I (2009) Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Rev 19:152–168CrossRefPubMedPubMedCentral

Yarlott L, Heald E, Forton D (2017) Hepatitis C virus infection, and neurological and psychiatric disorders—a review. J Adv Res 8:139–148CrossRefPubMed

Title: Neurocognitive impairment with hepatitis C and HIV co-infection in Southern Brazil
Authors: Sérgio Monteiro de Almeida
Ana Paula de Pereira
Maria Lucia Alves Pedroso
Clea E. Ribeiro
Indianara Rotta
Bin Tang
Anya Umlauf
Donald Franklin
Rowan G. Saloner
Maria Geny Ribas Batista
Scott Letendre
Robert K. Heaton
Ronald J. Ellis
Mariana Cherner
the HNRC Group
Publication date: 01-06-2018
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 3/2018
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-018-0617-5

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Neurocognitive impairment with hepatitis C and HIV co-infection in Southern Brazil

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