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01-12-2018

Screening for viral nucleic acids in vestibular schwannoma

Authors: Aril Løge Håvik, Ove Bruland, Mads Aarhus, Karl-Henning Kalland, Tomasz Stokowy, Morten Lund-Johansen, Per-Morten Knappskog

Published in: Journal of NeuroVirology | Issue 6/2018

Abstract

To investigate if viruses are involved in the pathogenesis of vestibular schwannomas (VS), we have screened biopsies from VS patients using different molecular techniques. Screening for the presence of known viruses using a pan-viral microarray assay (ViroChip) indicated the presence of several viruses including human endogenous retrovirus K (HERV-K) and human herpes virus 2 (HHV2). But with the exception of HERV-K, none of the findings could be verified by other methods. Whole transcriptome sequencing showed only the presence of HERV-K transcripts and whole genome sequencing showed only the presence of Epstein-Barr virus, most likely originating from infiltration of lymphocytes. We therefore conclude that it is less likely that viruses are involved in the pathogenesis of vestibular schwannomas.

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Title: Screening for viral nucleic acids in vestibular schwannoma
Authors: Aril Løge Håvik
Ove Bruland
Mads Aarhus
Karl-Henning Kalland
Tomasz Stokowy
Morten Lund-Johansen
Per-Morten Knappskog
Publication date: 01-12-2018
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 6/2018
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-018-0669-6

At a glance: The STEP trials

Springer Medicine

Screening for viral nucleic acids in vestibular schwannoma

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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