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01-10-2020 | Magnetic Resonance Imaging | Original Work

Optic Nerve Sheath Diameter is not Related to Intracranial Pressure in Subarachnoid Hemorrhage Patients

Authors: Tommaso Zoerle, Alessio Caccioppola, Eleonora D’Angelo, Marco Carbonara, Giorgio Conte, Sabrina Avignone, Elisa R. Zanier, Tatiana Birg, Fabrizio Ortolano, Fabio Triulzi, Nino Stocchetti

Published in: Neurocritical Care | Issue 2/2020

Abstract

Background

Intracranial pressure (ICP) monitoring is essential after subarachnoid hemorrhage (SAH) to prevent secondary brain insults and to tailor individualized treatments. Optic nerve sheath diameter (ONSD), measured using ultrasound (US), could serve as a noninvasive bedside tool to estimate ICP, avoiding the risks of hemorrhage or infection related to intracranial catheters. The aims of this study were twofold: first, to explore the reliability of US for measuring ONSD; second, to establish whether the US-ONSD can be considered a proxy for ICP in SAH patients early after bleeding. For the first aim, we compared the ONSD measurements given by magnetic resonance imaging (MRI-ONSD) with the US-ONSD findings. For the second aim, we analyzed the relationship between US-ONSD measurements and ICP values.

Methods

Adult patients with diagnosis of aneurysmal SAH and external ventricular drainage system (EVD) were included. Ten patients were examined by MRI to assess ONSD, and the results were compared to the diameter given by US. In 20 patients, the US-ONSD values were related to ICP measured simultaneously through EVD. In ten of these patients, we explored the changes in the US-ONSD at the time of controlled and fairly rapid changes in ICP after cerebrospinal fluid (CSF) drainage.

Results

US-ONSD measurements at the bedside were accurate, very similar to the diameters measured by MRI (the mean difference in the Bland–Altman plot was 0.08 mm, 95% limits of agreement: − 1.13; + 1.23 mm). No clear relationship was detectable between the ICP and US-ONSD, and a linear regression model showed an angular coefficient very close to 0 (p > 0.05). US-ONSD and ICP values were in agreement after CSF drainage and shifts in ICP in a limited number of patients.

Conclusions

US-ONSD measurement does not accurately estimate ICP in SAH patients in the intensive care unit.

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Title: Optic Nerve Sheath Diameter is not Related to Intracranial Pressure in Subarachnoid Hemorrhage Patients
Authors: Tommaso Zoerle
Alessio Caccioppola
Eleonora D’Angelo
Marco Carbonara
Giorgio Conte
Sabrina Avignone
Elisa R. Zanier
Tatiana Birg
Fabrizio Ortolano
Fabio Triulzi
Nino Stocchetti
Publication date: 01-10-2020
Publisher: Springer US
Keywords: Magnetic Resonance Imaging
Subarachnoid Hemorrhage
Ultrasound
Magnetic Resonance Imaging
Intracranial Hypertension
Subarachnoid Hemorrhage
CSF Drainage
Ultrasound
Published in: Neurocritical Care / Issue 2/2020
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-020-00970-y

At a glance: The STEP trials

Springer Medicine

Optic Nerve Sheath Diameter is not Related to Intracranial Pressure in Subarachnoid Hemorrhage Patients

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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