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Neurocritical Care
Published in: Neurocritical Care 3/2023

24-02-2023 | Magnetic Resonance Imaging | Neuroimage

Delayed Diffusion Restriction of Wallerian Degeneration

Authors: Daniel J. Zhou, Daryl R. Gress, Maximiliano A. Hawkes

Published in: Neurocritical Care | Issue 3/2023

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Excerpt

Wallerian degeneration (WD) is the anterograde degeneration of axons following a proximal neuronal injury [1]. In the brain, WD has been described as commonly affecting the corticospinal tract after various insults [2, 3]. Diffusion-weighted imaging (DWI) and diffusion tensor imaging sequences on magnetic resonance imaging (MRI) can precisely detect WD from the altered water content of affected tracts days to months after the initial insult [4‐6]. Its behavior on apparent diffusion coefficient (ADC) is variable [7]. We describe the unique case of WD of corticobulbar fibers in the brain visualized as a restrictive lesion on MRI-DWI sequences 13 months after an intracerebral hemorrhage (ICH). …
Literature
1.
Conforti L, Gilley J, Coleman MP. Wallerian degeneration: an emerging axon death pathway linking injury and disease. Nat Rev Neurosci. 2014;15(6):394–409.CrossRefPubMed
2.
Sawlani V, Gupta RK, Singh MK, Kohli A. MRI demonstration of Wallerian degeneration in various intracranial lesions and its clinical implications. J Neurol Sci. 1997;146(2):103–8.CrossRefPubMed
3.
Venkatasubramanian C, Kleinman JT, Fischbein NJ, Olivot JM, Gean AD, Eyngorn I, et al. Natural history and prognostic value of corticospinal tract Wallerian degeneration in intracerebral hemorrhage. J Am Heart Assoc. 2013;2(4):e000090.CrossRefPubMedPubMedCentral
4.
Werring DJ, Toosy AT, Clark CA, Parker GJ, Barker GJ, Miller DH, Thompson AJ. Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke. J Neurol Neurosurg Psychiatry. 2000;69(2):269–72.CrossRefPubMedPubMedCentral
5.
Uchino A, Sawada A, Takase Y, Egashira R, Kudo S. Transient detection of early Wallerian degeneration on diffusion-weighted MRI after an acute cerebrovascular accident. Neuroradiology. 2004;46(3):183–8.CrossRefPubMed
6.
Thomalla G, Glauche V, Weiller C, Rother J. Time course of wallerian degeneration after ischaemic stroke revealed by diffusion tensor imaging. J Neurol Neurosurg Psychiatry. 2005;76(2):266–8.CrossRefPubMedPubMedCentral
7.
Musson R, Romanowski C. Restricted diffusion in Wallerian degeneration of the middle cerebellar peduncles following pontine infarction. Pol J Radiol. 2010;75(4):38–43.PubMedPubMedCentral
8.
Wycoco V, Shroff M, Sudhakar S, Lee W. White matter anatomy: what the radiologist needs to know. Neuroimaging Clin N Am. 2013;23(2):197–216.CrossRefPubMed
9.
Chen YJ, Nabavizadeh SA, Vossough A, Kumar S, Loevner LA, Mohan S. Wallerian degeneration beyond the corticospinal tracts: conventional and advanced MRI findings. J Neuroimaging. 2017;27(3):272–80.CrossRefPubMed
10.
Vargas ME, Barres BA. Why is Wallerian degeneration in the CNS so slow? Annu Rev Neurosci. 2007;30:153–79.CrossRefPubMed
11.
Qin W, Zhang M, Piao Y, Guo D, Zhu Z, Tian X, et al. Wallerian degeneration in central nervous system: dynamic associations between diffusion indices and their underlying pathology. PLoS ONE. 2012;7(7):e41441.CrossRefPubMedPubMedCentral
12.
Bekiesinska-Figatowska M, Duczkowski M, Madzik J, Uliasz M, Zawadka A, Baszczeska J. Diffusion-weighted imaging of the early phase of Wallerian degeneration. A report of two pediatric cases and literature review. Neuroradiol J. 2012;25(6):657–64.CrossRefPubMed
13.
Castillo M, Mukherji SK. Early abnormalities related to postinfarction Wallerian degeneration: evaluation with MR diffusion-weighted imaging. J Comput Assist Tomogr. 1999;23(6):1004–7.CrossRefPubMed
14.
DeVetten G, Coutts SB, Hill MD, Goyal M, Eesa M, O’Brien B, et al. Acute corticospinal tract Wallerian degeneration is associated with stroke outcome. Stroke. 2010;41(4):751–6.CrossRefPubMed
15.
Jimenez-Gomez A, Stowe RC. Teaching neuroimages: Wallerian degeneration in evolving pediatric stroke. Neurology. 2017;89(13):e166–7.CrossRefPubMed
16.
Kang DW, Chu K, Yoon BW, Song IC, Chang KH, Roh JK. Diffusion-weighted imaging in Wallerian degeneration. J Neurol Sci. 2000;178(2):167–9.CrossRefPubMed
17.
Liu X, Tian W, Li L, Kolar B, Qiu X, Chen F, et al. Hyperintensity on diffusion weighted image along ipsilateral cortical spinal tract after cerebral ischemic stroke: a diffusion tensor analysis. Eur J Radiol. 2012;81(2):292–7.CrossRefPubMed
18.
Ni J, Li ML, Yao M, Cui LY. Early corticospinal tract Wallerian degeneration on diffusion-weighted MR imaging after adult stroke: three cases report. Clin Neurol Neurosurg. 2013;115(7):1164–6.CrossRefPubMed
19.
Sylaja RN, Goyal M, Watson T, Hill MD. Wallerian-like degeneration after ischemic stroke revealed by diffusion-weighted imaging. Can J Neurol Sci. 2007;34(2):243–4.CrossRefPubMed
20.
Xu SY, Li CX, Li LY, Song Y, Sui Y. Wallerian degeneration of bilateral cerebral peduncles after acute carbon monoxide poisoning. BMC Neurol. 2020;20(1):96.CrossRefPubMedPubMedCentral
21.
Hekimoglu A, Suer Dogan I, Turan A, Oztekin MF, Hekimoglu B. Bilateral Wallerian degeneration of the pontocerebellar tracts. Case Rep Emerg Med. 2015;2015:970570.PubMedPubMedCentral
22.
Kim HJ, Moon WJ. Prolonged Wallerian degeneration in the corticospinal tract following external capsular hemorrhage. J Neurol Sci. 2016;365:154–5.CrossRefPubMed
23.
Metadata
Title
Delayed Diffusion Restriction of Wallerian Degeneration
Authors
Daniel J. Zhou
Daryl R. Gress
Maximiliano A. Hawkes
Publication date
24-02-2023
Publisher
Springer US
Published in
Neurocritical Care / Issue 3/2023
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-023-01692-7

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