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01-05-2021 | Lymphoma | Review Article

The role of interleukins and the widely studied TNF-α in non-Hodgkin’s lymphoma

Authors: Kyle P. D’mello, Lei Zhao, Erin C. Kaser, Ziwen Zhu, Huaping Xiao, Mark R. Wakefield, Qian Bai, Yujiang Fang

Published in: Medical Oncology | Issue 5/2021

Abstract

Non-Hodgkin’s lymphoma is a relatively common cancer with malignant tendencies. Although there is no current cure for the disease, research has been successful in figuring out the mechanisms of how the disease progresses, however, there is still a lot of unknowns, and more research must be done to find the ultimate cause of the disease. Interleukins and various cytokines play unique roles in the development of cancer. This review article summarizes the pathophysiology between certain interleukins and non-Hodgkin’s lymphoma. Although TNF-α is not an interleukin, the article examines TNF-α due to its high correspondence with cancer. The article also describes a promising immunotherapy for the disease, while looking at immunotherapies that have been successful in other types of cancer and disease.

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Title: The role of interleukins and the widely studied TNF-α in non-Hodgkin’s lymphoma
Authors: Kyle P. D’mello
Lei Zhao
Erin C. Kaser
Ziwen Zhu
Huaping Xiao
Mark R. Wakefield
Qian Bai
Yujiang Fang
Publication date: 01-05-2021
Publisher: Springer US
Keyword: Lymphoma
Published in: Medical Oncology / Issue 5/2021
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-021-01504-y

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