Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Respiratory Research
Published in: Respiratory Research 1/2022

Open Access 01-12-2022 | Lung Cancer | Research

Wood smoke exposure affects lung aging, quality of life, and all-cause mortality in New Mexican smokers

Authors: Shuguang Leng, Maria A. Picchi, Paula M. Meek, Menghui Jiang, Samuel H. Bayliss, Ting Zhai, Ruslan I. Bayliyev, Yohannes Tesfaigzi, Matthew J. Campen, Huining Kang, Yiliang Zhu, Qing Lan, Akshay Sood, Steven A. Belinsky

Published in: Respiratory Research | Issue 1/2022

Login to get access

Abstract

Background

The role of wood smoke (WS) exposure in the etiology of chronic obstructive pulmonary disease (COPD), lung cancer (LC), and mortality remains elusive in adults from countries with low ambient levels of combustion-emitted particulate matter. This study aims to delineate the impact of WS exposure on lung health and mortality in adults age 40 and older who ever smoked.

Methods

We assessed health impact of self-reported “ever WS exposure for over a year” in the Lovelace Smokers Cohort using both objective measures (i.e., lung function decline, LC incidence, and deaths) and two health related quality-of-life questionnaires (i.e., lung disease-specific St. George's Respiratory Questionnaire [SGRQ] and the generic 36-item short-form health survey).

Results

Compared to subjects without WS exposure, subjects with WS exposure had a more rapid decline of FEV1 (− 4.3 ml/s, P = 0.025) and FEV1/FVC ratio (− 0.093%, P = 0.015), but not of FVC (− 2.4 ml, P = 0.30). Age modified the impacts of WS exposure on lung function decline. WS exposure impaired all health domains with the increase in SGRQ scores exceeding the minimal clinically important difference. WS exposure increased hazard for incidence of LC and death of all-cause, cardiopulmonary diseases, and cancers by > 50% and shortened the lifespan by 3.5 year. We found no evidence for differential misclassification or confounding from socioeconomic status for the health effects of WS exposure.

Conclusions

We identified epidemiological evidence supporting WS exposure as an independent etiological factor for the development of COPD through accelerating lung function decline in an obstructive pattern. Time-to-event analyses of LC incidence and cancer-specific mortality provide human evidence supporting the carcinogenicity of WS exposure.
Appendix
Available only for authorised users
Literature
1.
Orr A, C ALM, Buford M, Ballou S, Migliaccio CT. Sustained effects on lung function in community members following exposure to hazardous PM2.5 levels from wildfire smoke. Toxics 2020; 8.
2.
Wargo J, Alderman N, Wargo L, Bradley J, Addiss S. The harmful effects of wood smoke and the growth of recreational wood burning. 2018.
3.
Ward T, Lange T. The impact of wood smoke on ambient PM2.5 in northern Rocky Mountain valley communities. Environ Pollut. 2010;158:723–9.PubMedCrossRef
4.
Ward T, Trost B, Conner J, Flanagan J, Jayanty RKM. Source apportionment of PM2.5 in a subarctic Airshed—Fairbanks, Alaska. Aerosol Air Qual Res. 2012;12:536–43.CrossRef
5.
Agency USEP. Strategies for reducing residential wood smoke. pp. 45: United States Environmental Protection Agency 2013:45.
6.
Meek P, Petersen H, Irshad H, Vazquez Guillamet R, McDonald J, Sood A, Tesfaigzi Y. Age of wood stove does not correlate with household air pollution measures. In: ATS 2020 International Conference. 2020.
7.
8.
Bede-Ojimadu O, Orisakwe OE. Exposure to wood smoke and associated health effects in Sub-Saharan Africa: a systematic review. Ann Glob Health. 2020;86:32.PubMedPubMedCentralCrossRef
9.
Chan KH, Kurmi OP, Bennett DA, Yang L, Chen Y, Tan Y, Pei P, Zhong X, Chen J, Zhang J, et al. Solid fuel use and risks of respiratory diseases. A cohort study of 280,000 Chinese never-smokers. Am J Respir Crit Care Med. 2019;199:352–61.PubMedPubMedCentralCrossRef
10.
Morandi MT, Ward TJ, Risk Assessment W. Wood smoke risk assessment: defining the questions. Inhal Toxicol. 2010;22:94–8.PubMedCrossRef
11.
Noonan CW, Semmens EO, Ware D, Smith P, Boyer BB, Erdei E, Hopkins SE, Lewis J, Ward TJ. Wood stove interventions and child respiratory infections in rural communities: KidsAir rationale and methods. Contemp Clin Trials. 2020;89: 105909.PubMedCrossRef
12.
13.
Sood A, Petersen H, Blanchette CM, Meek P, Picchi MA, Belinsky SA, Tesfaigzi Y. Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers. Am J Respir Crit Care Med. 2010;182:1098–104.PubMedPubMedCentralCrossRef
14.
Brandsma CA, de Vries M, Costa R, Woldhuis RR, Konigshoff M, Timens W. Lung ageing and COPD: is there a role for ageing in abnormal tissue repair? Eur Respir Rev. 2017; 26.
15.
Thannickal VJ, Murthy M, Balch WE, Chandel NS, Meiners S, Eickelberg O, Selman M, Pardo A, White ES, Levy BD, et al. Blue journal conference. Aging and susceptibility to lung disease. Am J Respir Crit Care Med. 2015;191:261–9.PubMedPubMedCentralCrossRef
16.
Meiners S, Eickelberg O, Konigshoff M. Hallmarks of the ageing lung. Eur Respir J. 2015;45:807–27.PubMedCrossRef
17.
Mannino DM, Reichert MM, Davis KJ. Lung function decline and outcomes in an adult population. Am J Respir Crit Care Med. 2006;173:985–90.PubMedCrossRef
18.
19.
Chang KKP, Wong FKY, Chan KL, Wong F, Ho HC, Wong MS, Ho YS, Yuen JWM, Siu JY, Yang L. The impact of the environment on the quality of life and the mediating effects of sleep and stress. Int J Environ Res Public Health. 2020; 17.
20.
Haraldstad K, Wahl A, Andenaes R, Andersen JR, Andersen MH, Beisland E, Borge CR, Engebretsen E, Eisemann M, Halvorsrud L, et al. A systematic review of quality of life research in medicine and health sciences. Qual Life Res. 2019;28:2641–50.PubMedPubMedCentralCrossRef
21.
Hansel NN, Putcha N, Woo H, Peng R, Diette GB, Fawzy A, Wise RA, Romero K, Davis MF, Rule AM, et al. Randomized clinical trial of air cleaners to improve indoor air quality and COPD health: results of the Clean Air Study. Am J Respir Crit Care Med. 2021.
22.
Ware JE Jr, Gandek B, Kosinski M, Aaronson NK, Apolone G, Brazier J, Bullinger M, Kaasa S, Leplege A, Prieto L, et al. The equivalence of SF-36 summary health scores estimated using standard and country-specific algorithms in 10 countries: results from the IQOLA Project. International Quality of Life Assessment. J Clin Epidemiol. 1998;51:1167–70.PubMedCrossRef
23.
Alexander D, Linnes JC, Bolton S, Larson T. Ventilated cookstoves associated with improvements in respiratory health-related quality of life in rural Bolivia. J Public Health (Oxf). 2014;36:460–6.CrossRef
24.
Sood A, Assad NA, Barnes PJ, Churg A, Gordon SB, Harrod KS, Irshad H, Kurmi OP, Martin WJ, 2nd, Meek P, et al. ERS/ATS workshop report on respiratory health effects of household air pollution. Eur Respir J. 2018; 51.
25.
Hosgood HD 3rd, Boffetta P, Greenland S, Lee YC, McLaughlin J, Seow A, Duell EJ, Andrew AS, Zaridze D, Szeszenia-Dabrowska N, et al. In-home coal and wood use and lung cancer risk: a pooled analysis of the International Lung Cancer Consortium. Environ Health Perspect. 2010;118:1743–7.PubMedPubMedCentralCrossRef
26.
Kromhout H, Heederik D, Dalderup LM, Kromhout D. Performance of two general job-exposure matrices in a study of lung cancer morbidity in the Zutphen cohort. Am J Epidemiol. 1992;136:698–711.PubMedCrossRef
27.
Sunyer J, Kogevinas M, Kromhout H, Anto JM, Roca J, Tobias A, Vermeulen R, Payo F, Maldonado JA, Martinez-Moratalla J, Muniozguren N. Pulmonary ventilatory defects and occupational exposures in a population-based study in Spain. Spanish Group of the European Community Respiratory Health Survey. Am J Respir Crit Care Med. 1998;157:512–7.PubMedCrossRef
28.
Stidley CA, Picchi MA, Leng S, Willink R, Crowell RE, Flores KG, Kang H, Byers T, Gilliland FD, Belinsky SA. Multivitamins, folate, and green vegetables protect against gene promoter methylation in the aerodigestive tract of smokers. Cancer Res. 2010;70:568–74.PubMedPubMedCentralCrossRef
29.
Leng S, Stidley CA, Willink R, Bernauer A, Do K, Picchi MA, Sheng X, Frasco MA, Van Den Berg D, Gilliland FD, et al. Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation. Cancer Res. 2008;68:3049–56.PubMedPubMedCentralCrossRef
30.
Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med. 1995; 152:1107–1136.
31.
Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS, GS Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med. 2001;163:1256–76.PubMedCrossRef
32.
Kelly A, Rush J, Shafonsky E, Hayashi A, Votova K, Hall C, Piccinin AM, Weber J, Rast P, Hofer SM. Detecting short-term change and variation in health-related quality of life: within- and between-person factor structure of the SF-36 health survey. Health Qual Life Outcomes. 2015;13:199.PubMedPubMedCentralCrossRef
33.
34.
Jones PW, Quirk FH, Baveystock CM. The St George’s respiratory questionnaire. Respir Med. 1991;85(Suppl B):25–31 (discussion 33–27).PubMedCrossRef
35.
36.
Belinsky SA, Liechty KC, Gentry FD, Wolf HJ, Rogers J, Vu K, Haney J, Kennedy TC, Hirsch FR, Miller Y, et al. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res. 2006;66:3338–44.PubMedCrossRef
37.
Bruse S, Petersen H, Weissfeld J, Picchi M, Willink R, Do K, Siegfried J, Belinsky SA, Tesfaigzi Y. Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion. Respir Res. 2014;15:2.PubMedPubMedCentralCrossRef
38.
Leng S, Diergaarde B, Picchi MA, Wilson DO, Gilliland FD, Yuan JM, Siegfried JM, Belinsky SA. Gene promoter hypermethylation detected in sputum predicts FEV1 decline and all-cause mortality in smokers. Am J Respir Crit Care Med. 2018;198:187–96.PubMedPubMedCentralCrossRef
39.
Leng S, Picchi MA, Tesfaigzi Y, Wu G, Gauderman WJ, Xu F, Gilliland FD, Belinsky SA. Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico. Int J Chron Obstruct Pulmon Dis. 2017;12:3171–81.PubMedPubMedCentralCrossRef
40.
Petersen H, Vazquez Guillamet R, Meek P, Sood A, Tesfaigzi Y. Early endotyping: a chance for intervention in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2018;59:13–7.PubMedPubMedCentralCrossRef
41.
Jones PW. Interpreting thresholds for a clinically significant change in health status in asthma and COPD. Eur Respir J. 2002;19:398–404.PubMedCrossRef
42.
Jones PW. Quality of life, symptoms and pulmonary function in asthma: long-term treatment with nedocromil sodium examined in a controlled multicentre trial. Nedocromil Sodium Quality of Life Study Group. Eur Respir J. 1994;7:55–62.PubMedCrossRef
43.
Gonzalez-Garcia M, Torres-Duque C. Wood smoke COPD: a new description of a COPD phenotype? Eur Respir J. 2014;44:261–2.PubMedCrossRef
44.
Lange P, Celli B, Agusti A, Boje Jensen G, Divo M, Faner R, Guerra S, Marott JL, Martinez FD, Martinez-Camblor P, et al. Lung-function trajectories leading to chronic obstructive pulmonary disease. N Engl J Med. 2015;373:111–22.PubMedCrossRef
45.
Sapkota A, Zaridze D, Szeszenia-Dabrowska N, Mates D, Fabianova E, Rudnai P, Janout V, Holcatova I, Brennan P, Boffetta P, Hashibe M. Indoor air pollution from solid fuels and risk of upper aerodigestive tract cancers in central and eastern Europe. Environ Res. 2013;120:90–5.PubMedCrossRef
46.
Kurmi OP, Arya PH, Lam KB, Sorahan T, Ayres JG. Lung cancer risk and solid fuel smoke exposure: a systematic review and meta-analysis. Eur Respir J. 2012;40:1228–37.PubMedCrossRef
47.
Bruce N, Dherani M, Liu R, Hosgood HD 3rd, Sapkota A, Smith KR, Straif K, Lan Q, Pope D. Does household use of biomass fuel cause lung cancer? A systematic review and evaluation of the evidence for the GBD 2010 study. Thorax. 2015;70:433–41.PubMedCrossRef
48.
Black C, Tesfaigzi Y, Bassein JA, Miller LA. Wildfire smoke exposure and human health: significant gaps in research for a growing public health issue. Environ Toxicol Pharmacol. 2017;55:186–95.PubMedPubMedCentralCrossRef
49.
Daisey JM, Mahanama KR, Hodgson AT. Toxic volatile organic compounds in simulated environmental tobacco smoke: emission factors for exposure assessment. J Expo Anal Environ Epidemiol. 1998;8:313–34.PubMed
50.
Hildemann LM, Markowski GR, Cass GR. Chemical composition of emissions from urban sources of fine organic aerosol. Environ Sci Technol. 1991;25:744–59.CrossRef
51.
Cheng W, Liu Y, Tang J, Duan H, Wei X, Zhang X, Yu S, Campen MJ, Han W, Rothman N, et al. Carbon content in airway macrophages and genomic instability in Chinese carbon black packers. Arch Toxicol. 2020.
52.
Tassew D, Fort S, Mebratu Y, McDonald J, Chu HW, Petersen H, Tesfaigzi Y. Effects of wood smoke constituents on mucin gene expression in mice and human airway epithelial cells and on nasal epithelia of subjects with a susceptibility gene variant in Tp53. Environ Health Perspect. 2022;130:17010.PubMedCrossRef
53.
Brock MV, Hooker CM, Ota-Machida E, Han Y, Guo M, Ames S, Glockner S, Piantadosi S, Gabrielson E, Pridham G, et al. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med. 2008;358:1118–28.PubMedCrossRef
54.
Leng S, Do K, Yingling CM, Picchi MA, Wolf HJ, Kennedy TC, Feser WJ, Baron AE, Franklin WA, Brock MV, et al. Defining a gene promoter methylation signature in sputum for lung cancer risk assessment. Clin Cancer Res. 2012;18:3387–95.PubMedPubMedCentralCrossRef
55.
Belinsky SA. Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer. 2004;4:707–17.PubMedCrossRef
56.
Meek PM, Sood A, Petersen H, Belinsky SA, Tesfaigzi Y. Epigenetic change (GATA-4 gene methylation) is associated with health status in chronic obstructive pulmonary disease. Biol Res Nurs. 2015;17:191–8.PubMedCrossRef
57.
58.
Leng S, Nguyen K, Picchi M, Meek P, Tesfaigzi Y, Sood A, Belinsky S. Self-reported wood smoke exposure is associated with rapid decline of FEV1 and FEV1/FVC ratio in lovelace smokers cohort: a longitudinal analysis. In: ATS 2021 International Conference; San Diego. 2021.
Metadata
Title
Wood smoke exposure affects lung aging, quality of life, and all-cause mortality in New Mexican smokers
Authors
Shuguang Leng
Maria A. Picchi
Paula M. Meek
Menghui Jiang
Samuel H. Bayliss
Ting Zhai
Ruslan I. Bayliyev
Yohannes Tesfaigzi
Matthew J. Campen
Huining Kang
Yiliang Zhu
Qing Lan
Akshay Sood
Steven A. Belinsky
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2022
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-022-02162-y

Other articles of this Issue 1/2022

Respiratory Research 1/2022 Go to the issue

Research

The association between regional transcriptome profiles and lung volumes in response to mechanical ventilation and lung injury

Research

Feasibility of a genotyping system for the diagnosis of alpha1 antitrypsin deficiency: a multinational cross-sectional analysis

Research

The burden of chronic respiratory disease and attributable risk factors in North Africa and Middle East: findings from global burden of disease study (GBD) 2019

Research

Respiratory system compliance at the same PEEP level is similar in COVID and non-COVID ARDS

Research

Gene network analysis for identification of microRNA biomarkers for asthma

Research

Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits