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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2019

01-12-2019 | Metastasis | ASO Author Reflections

ASO Author Reflections: Clinical Significance of Primary Tumor Side in Peritoneal Metastatic Colon Cancer

Authors: Nikhil V. Kotha, MD, Kaitlyn J. Kelly, MD

Published in: Annals of Surgical Oncology | Special Issue 3/2019

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Excerpt

Colon cancers are classified as right- or left-sided based on the location of the primary tumor relative to the splenic flexure. It is known that colon adenocarcinomas arising from the right side are clinically and biologically different from those arising from the left side in terms of presentation, pathologic characteristics, molecular aberrations, and outcomes.1 A right-sided primary tumor has been shown to be prognostic of worse disease-free (DFS) and overall survival (OS) in patients with systemic metastasis treated with palliative chemotherapy, and in patients with regional liver metastasis treated with curative-intent surgery.2 Patients with metastasis to the peritoneum represent a small subset of colon cancer patients, but they have a particularly poor prognosis.3 The impact of primary tumor side on patients with peritoneal metastatic colon cancer treated with cytoreduction with or without hyperthermic intraperitoneal chemotherapy (HIPEC) has not been well characterized. …
Literature
1.
Lee GH, Malietzis G, Askari A, Bernardo D, Al-Hassi HO, Clark SK. Is right-sided colon cancer different to left-sided colorectal cancer? A systematic review. Eur J Surg Oncol. 2015;41(3):300–8.CrossRef
2.
Creasy JM, Sadot E, Koerkamp BG, et al. The impact of primary tumor location on long-term survival in patients undergoing hepatic resection for metastatic colon cancer. Ann Surg Oncol. 2018;25(2):431–8.CrossRef
3.
Franko J, Shi Q, Meyers JP, et al. Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the analysis and research in cancers of the digestive system (ARCAD) database. Lancet Oncol. 2016;17(12):1709–19.CrossRef
4.
Kelly KJ, Alsayadnasser M, Vaida F, et al. Does primary tumor side matter in patients with metastatic colon cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy? Ann Surg Oncol. 2019;26(5):1421–7.CrossRef
5.
Kotha NV, Baumgartner JM, Veerapong JV, et al. Primary tumor sidedness is predictive of survival in colon cancer patients treated with cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy: a US HIPEC collaborative study. Ann Surg Oncol. 2019;26:2234–40.CrossRef
6.
Amin MB, American Joint Committee on Cancer, American Cancer Society. AJCC cancer staging manual. 8th ed. Chicago, IL: American Joint Committee on Cancer, Springer; 2017.
Metadata
Title
ASO Author Reflections: Clinical Significance of Primary Tumor Side in Peritoneal Metastatic Colon Cancer
Authors
Nikhil V. Kotha, MD
Kaitlyn J. Kelly, MD
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07916-5

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