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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2019

01-12-2019 | Liver Resection | ASO Author Reflections

ASO Author Reflections: Preoperative Hypercoagulability Predicts Poor Prognosis in Hepatocellular Carcinoma Patients with Microvascular Invasion After Hepatectomy

Authors: Xiu-Ping Zhang, MD, Shu-Qun Cheng, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2019

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Excerpt

Microvascular invasion (MVI) predicts poor prognosis in patients with hepatocellular carcinoma (HCC).1 Many cancer patients are in a hypercoagulability state and venous thromboembolic events can be the first presentation of cancer.2,3 To our knowledge, there is no information on the preoperative coagulability state, as reflected by the international normalized ratio (INR) level in HCC patients, correlating with the incidence of MVI and the long-term survival outcomes in patients with HCC and MVI after R0 liver resection (LR). …
Literature
1.
Roayaie S, Blume IN, Thung SN, et al. A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma. Gastroenterology. 2009;137(3):850–5.CrossRef
2.
Campello E, Zanetto A, Spiezia L, et al. Hypercoagulability detected by circulating microparticles in patients with hepatocellular carcinoma and cirrhosis. Thromb Res. 2016;143:118–21.CrossRef
3.
Zanetto A, Campello E, Spiezia L, Burra P, Simioni P, Russo FP. Cancer-associated thrombosis in cirrhotic patients with hepatocellular carcinoma. Cancers (Basel). 2018;10(11):450.CrossRef
4.
Zhang XP, Zhou TF, Wang ZH, et al. Association of preoperative hypercoagulability with poor prognosis in hepatocellular carcinoma patients with microvascular invasion after liver resection: a multicenter study. Ann Surg Oncol. 2019;26(12):4117–25.CrossRef
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Farge D, Bounameaux H, Brenner B, et al. International clinical practice guidelines including guidance for direct oral anticoagulants in the treatment and prophylaxis of venous thromboembolism in patients with cancer. Lancet Oncol. 2016;17(10):e452–66.CrossRef
Metadata
Title
ASO Author Reflections: Preoperative Hypercoagulability Predicts Poor Prognosis in Hepatocellular Carcinoma Patients with Microvascular Invasion After Hepatectomy
Authors
Xiu-Ping Zhang, MD
Shu-Qun Cheng, MD, PhD
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07986-5

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