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Molecular and Cellular Pediatrics
Published in: Molecular and Cellular Pediatrics 1/2021

Open Access 01-12-2021 | Growth Factors | Review

Patho-mechanisms of the origins of bronchopulmonary dysplasia

Authors: Mitali Sahni, Vineet Bhandari

Published in: Molecular and Cellular Pediatrics | Issue 1/2021

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Abstract

Bronchopulmonary dysplasia (BPD) continues to be one of the most common complications of prematurity, despite significant advancement in neonatology over the last couple of decades. The new BPD is characterized histopathologically by impaired lung alveolarization and dysregulated vascularization. With the increased survival of extremely preterm infants, the risk for the development of BPD remains high, emphasizing the continued need to understand the patho-mechanisms that play a role in the development of this disease. This brief review summarizes recent advances in our understanding of the maldevelopment of the premature lung, highlighting recent research in pathways of oxidative stress-related lung injury, the role of placental insufficiency, growth factor signaling, the extracellular matrix, and microRNAs.
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Metadata
Title
Patho-mechanisms of the origins of bronchopulmonary dysplasia
Authors
Mitali Sahni
Vineet Bhandari
Publication date
01-12-2021
Publisher
Springer Berlin Heidelberg
Published in
Molecular and Cellular Pediatrics / Issue 1/2021
Electronic ISSN: 2194-7791
DOI
https://doi.org/10.1186/s40348-021-00129-5

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