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BMC Pediatrics
Published in: BMC Pediatrics 1/2004

Open Access 01-12-2004 | Research article

Elevated platelet-derived growth factor-BB concentrations in premature neonates who develop chronic lung disease

Authors: Kim G Adcock, Jeremy Martin, John Loggins, Thomas E Kruger, R John Baier

Published in: BMC Pediatrics | Issue 1/2004

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Abstract

Background

Chronic lung disease (CLD) in the preterm newborn is associated with inflammation and fibrosis. Platelet-derived growth factor-BB (PDGF-BB), a potent chemotactic growth factor, may mediate the fibrotic component of CLD. The objectives of this study were to determine if tracheal aspirate (TA) concentrations of PDGF-BB increase the first 2 weeks of life in premature neonates undergoing mechanical ventilation for respiratory distress syndrome (RDS), its relationship to the development of CLD, pulmonary hemorrhage (PH) and its relationship to airway colonization with Ureaplasma urealyticum (Uu).

Methods

Infants with a birth weight less than 1500 grams who required mechanical ventilation for RDS were enrolled into this study with parental consent. Tracheal aspirates were collected daily during clinically indicated suctioning. Uu cultures were performed on TA collected in the first week of life. TA supernatants were assayed for PDGF-BB and secretory component of IgA concentrations using ELISA techniques.

Results

Fifty premature neonates were enrolled into the study. Twenty-eight infants were oxygen dependent at 28 days of life and 16 infants were oxygen dependent at 36 weeks postconceptual age. PDGF-BB concentrations peaked between 4 and 6 days of life. Maximum PDGF-BB concentrations were significantly higher in infants who developed CLD or died from respiratory failure. PH was associated with increased risk of CLD and was associated with higher PDGF-BB concentrations. There was no correlation between maximum PDGF-BB concentrations and Uu isolation from the airway.

Conclusions

PDGF-BB concentrations increase in TAs of infants who undergo mechanical ventilation for RDS during the first 2 weeks of life and maximal concentrations are greater in those infants who subsequently develop CLD. Elevation in lung PDGF-BB may play a role in the development of CLD.
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Metadata
Title
Elevated platelet-derived growth factor-BB concentrations in premature neonates who develop chronic lung disease
Authors
Kim G Adcock
Jeremy Martin
John Loggins
Thomas E Kruger
R John Baier
Publication date
01-12-2004
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2004
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/1471-2431-4-10

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