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Molecular and Cellular Pediatrics
Published in: Molecular and Cellular Pediatrics 1/2021

Open Access 01-12-2021 | Obesity | Research

Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity

Authors: Marta Ramon-Krauel, María Jesús Leal-Witt, Óscar Osorio-Conles, Montse Amat-Bou, Carles Lerin, David M. Selva

Published in: Molecular and Cellular Pediatrics | Issue 1/2021

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Abstract

Background

Sex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNFα and adiponectin regulate hepatic SHBG production.

Aim

The main objective of this study was to assess if the adult associations between TNFα, adiponectin, and SHBG are present in prepubertal children.

Methods

We determined several morphometric and biochemical parameters in normal-weight (n=15) and obese prepubertal (n=51) children, as well as quantified plasma SHBG, TNFα receptor 1 (TNFα-R1), and adiponectin levels.

Results

Our results showed that prepubertal children with obesity had decreased plasma SHBG levels compared to normal-weight controls (67 nmol/L vs 172 nmol/L). Importantly, SHBG plasma levels correlated significantly (P < 0.05) with TNFα (negatively, ßstd= − 0.31) and adiponectin (positively, ßstd= 0.58) suggesting an important role of these two cytokines in determining plasma SHBG levels in prepubertal children.

Conclusions

Our results suggest that plasma adiponectin levels may play a more important role than TNFα in influencing plasma SHBG levels in our prepubertal population with obesity.
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Metadata
Title
Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity
Authors
Marta Ramon-Krauel
María Jesús Leal-Witt
Óscar Osorio-Conles
Montse Amat-Bou
Carles Lerin
David M. Selva
Publication date
01-12-2021
Publisher
Springer Berlin Heidelberg
Published in
Molecular and Cellular Pediatrics / Issue 1/2021
Electronic ISSN: 2194-7791
DOI
https://doi.org/10.1186/s40348-021-00113-z

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