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Open Access 01-12-2018 | Review

Cell toxicity mechanism and biomarker

Author: Yong Zhang

Published in: Clinical and Translational Medicine | Issue 1/2018

Abstract

Cell toxicity may result in organ dysfunction and cause severe health problem. Recent studies revealed many toxicants may induced the over production of Nitric oxide, reactive oxygen species and the subsequent oxidative stress, cause cell toxicity. Mitochondrion dysfunction maybe the subsequent consequence of oxidative stress and has been recognized as another contributing factor in cell toxicity. Besides, oxidative products induced by some toxicants may also produce the compounds that damage cell DNA, leading to toxicity. Especially, the significance of nanoparticle induced cell toxicity was disclosed recently and attract more concern. The mechanism mainly includes inflammation, oxidative stress and DNA damage. On the other side, some biomarkers of cell toxicity including autophagy, cytokines, miRNA has been identified. The understanding of these phenomenon may enable us to clarify the cell toxicity mechanism then contribute to cell toxicity protection, disease treatment and drug side effect prevention.

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Title: Cell toxicity mechanism and biomarker
Author: Yong Zhang
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical and Translational Medicine / Issue 1/2018
Electronic ISSN: 2001-1326
DOI: https://doi.org/10.1186/s40169-018-0212-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Cell toxicity mechanism and biomarker

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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