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Clinical and Translational Medicine
Published in: Clinical and Translational Medicine 1/2017

Open Access 01-12-2017 | Review

Significance of long chain polyunsaturated fatty acids in human health

Authors: Rafael Zárate, Nabil el Jaber-Vazdekis, Noemi Tejera, José A. Pérez, Covadonga Rodríguez

Published in: Clinical and Translational Medicine | Issue 1/2017

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Abstract

In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid metabolism, together with their involvement in the occurrence of human disease. Of particular interest is the study of omega-3 and omega-6 long chain polyunsaturated fatty acids (LC-PUFAs), notably EPA (eicosapentaenoic acid, 20:5n-3), DHA (docosahexaenoic acid, 22:6n-3), and ARA (arachidonic acid, 20:4n-6), and their transformation into bioactive lipid mediators. In this sense, new families of PUFA-derived lipid mediators, including resolvins derived from EPA and DHA, and protectins and maresins derived from DHA, are being increasingly investigated because of their active role in the “return to homeostasis” process and resolution of inflammation. Recent findings reviewed in the present study highlight that the omega-6 fatty acid ARA appears increased, and omega-3 EPA and DHA decreased in most cancer tissues compared to normal ones, and that increments in omega-3 LC-PUFAs consumption and an omega-6/omega-3 ratio of 2–4:1, are associated with a reduced risk of breast, prostate, colon and renal cancers. Along with their lipid-lowering properties, omega-3 LC-PUFAs also exert cardioprotective functions, such as reducing platelet aggregation and inflammation, and controlling the presence of DHA in our body, especially in our liver and brain, which is crucial for optimal brain functionality. Considering that DHA is the principal omega-3 FA in cortical gray matter, the importance of DHA intake and its derived lipid mediators have been recently reported in patients with major depressive and bipolar disorders, Alzheimer disease, Parkinson’s disease, and amyotrophic lateral sclerosis. The present study reviews the relationships between major diseases occurring today in the Western world and LC-PUFAs. More specifically this review focuses on the dietary omega-3 LC-PUFAs and the omega-6/omega-3 balance, in a wide range of inflammation disorders, including autoimmune diseases. This review suggests that the current recommendations of consumption and/or supplementation of omega-3 FAs are specific to particular groups of age and physiological status, and still need more fine tuning for overall human health and well being.
Literature
1.
Bogyo M, Rudd PM (2013) New technologies and their impact on ‘omics’ research. Curr Opin Chem Biol 17(1):1–3PubMedCrossRef
2.
Simo C, Cifuentes A, GarciaCanas V (2014) Fundamentals of advanced omics technologies: from genes to metabolites. Elsevier Science Bv, Amsterdam
3.
Debnath M, Prasad GBKS, Bisen PS (2010) Omics technology. molecular diagnostics: promises and possibilities. Springer Netherlands, Dordrecht, pp 11–31CrossRef
4.
5.
6.
Hu CX, van der Heijden R, Wang M, van der Greef J, Hankemeier T, Xua GW (2009) Analytical strategies in lipidomics and applications in disease biomarker discovery. J Chromatogr B 877(26):2836–2846CrossRef
7.
Köfeler HC, Fauland A, Rechberger GN, Trötzmüller M (2012) Mass spectrometry based lipidomics: an overview of technological platforms. Metabolites 2(1):19–38PubMedPubMedCentralCrossRef
8.
Dewick PM (2001) The acetate pathway: fatty acids and polyketides. In: Medicinal natural products: A biosynthetic approach, 2nd edn. Wiley, Chichester, p 35–120
9.
Christie WW, Han X (2010) Lipid analysis isolation, separation, identification and lipidomic analysis, 4th edn. Oily Press, Bridgewater
10.
Calder PC (2015) Functional roles of fatty acids and their effects on human health. J Parenter Enteral Nutr 39(Suppl 1):18–32CrossRef
11.
Sayanova OV, Napier JA (2004) Eicosapentaenoic acid: biosynthetic routes and the potential for synthesis in transgenic plants. Phytochemistry 65(2):147–158PubMedCrossRef
12.
Sprecher H, Chen Q, Yin FQ (1999) Regulation of the biosynthesis of 22: 5n-6 and 22: 6n-3: a complex intracellular process. Lipids 34(1):153–156CrossRef
13.
Buzzi M, Henderson RJ, Sargent JR (1997) Biosynthesis of docosahexaenoic acid in trout hepatocytes proceeds via 24-carbon intermediates. Comp Biochem Physiol B Biochem Mol Biol. 116(2):263–267PubMedCrossRef
14.
Rodrı́guez C, Pérez JA, Henderson RJ (2002) The esterification and modification of n-3 and n-6 polyunsaturated fatty acids by hepatocytes and liver microsomes of turbot (Scophthalmus maximus). Comp Biochem Physiol B Biochem Mol Biol 132(3):559–570PubMedCrossRef
15.
Venegas-Calerón M, Beaudoin F, Sayanova O, Napier JA (2007) Co-transcribed Genes for Long Chain Polyunsaturated Fatty Acid Biosynthesis in the Protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme a synthase. J Biol Chem 282(5):2996–3003PubMedCrossRef
16.
Kothapalli KS, Ye K, Gadgil MS, Carlson SE, O’Brien KO, Zhang JY et al (2016) Positive selection on a regulatory insertion-deletion polymorphism in FADS2 influences apparent endogenous synthesis of arachidonic acid. Mol Biol Evol 29:msw049
17.
Burdge GC, Jones AE, Wootton SA (2002) Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men. Br J Nutr 88(04):355–363PubMedCrossRef
18.
Hussein N, Ah-Sing E, Wilkinson P, Leach C, Griffin BA, Millward DJ (2005) Long-chain conversion of [13C]linoleic acid and α-linolenic acid in response to marked changes in their dietary intake in men. J Lipid Res 46(2):269–280PubMedCrossRef
19.
20.
Plourde M, Cunnane SC (2007) Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab 32(4):619–634PubMedCrossRef
21.
Jacobson DL, Gange SJ, Rose NR, Graham NMH (1997) Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 84(3):223–243PubMedCrossRef
22.
Davidson A, Diamond B (2001) Autoimmune diseases. New Engl J Medicine Adv Inmunol 345:340–350CrossRef
23.
Nakazawa DJ (2009) The autoimmune epidemic: bodies gone haywire in a world out of balance. Touchstone/Simon & Schuster, New York
24.
Simopoulos AP (2001) Evolutionary aspects of diet and essential fatty acids. Karger Publishers, Fatty Acids Lipids New FindCrossRef
25.
Simopoulos AP (2016) An increase in the omega-6/omega-3 fatty acid ratio increases the risk for obesity. Nutrients 8(3):1–17CrossRef
26.
Borges MC, Santos FDM, Telles RW, Correia M, Lanna CCD (2014) Polyunsaturated omega-3 fatty acids and systemic lupus erythematosus: what do we know? Rev Bras Reumatol 54(6):459–466PubMedCrossRef
27.
Calder PC (2011) Fatty acids and inflammation: the cutting edge between food and pharma. Eur J Pharmacol 668(Suppl):50–58CrossRef
28.
29.
30.
31.
Smith WL, DeWitt DL, Garavito RM (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69:145–182PubMedCrossRef
32.
Kuhn H, O’Donnell VB (2006) Inflammation and immune regulation by 12/15-lipoxygenases. Prog Lipid Res 45(4):334–356PubMedCrossRef
33.
Morisseau C, Hammock BD (2013) Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol 53:37–58PubMedCrossRef
34.
Serhan CN, Chiang N, Dalli J, Levy BD (2015) Lipid mediators in the resolution of inflammation. Cold Spring Harbor Perspect Biol 7(2):a016311CrossRef
35.
Gross O, Thomas CJ, Guarda G, Tschopp J (2011) The inflammasome: an integrated view. Immunol Rev 243:136–151PubMedCrossRef
36.
Latz E, Xiao TS, Stutz A (2013) Activation and regulation of the inflammasomes. Nat Rev Immunol 13(6):397–411PubMedCrossRef
37.
38.
Pieters DJM, Mensink RP (2015) Effects of stearidonic acid on serum triacylglycerol concentrations in overweight and obese subjects: a randomized controlled trial. Eur J Clin Nutr 69(1):121–126PubMedCrossRef
39.
Klemens CM, Berman DR, Mozurkewich EL (2011) The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review. BJOG 118(8):916–925PubMedCrossRef
40.
Norris PC, Dennis EA (2012) Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. Proc Natl Acad Sci USA 109(22):8517–8522PubMedPubMedCentralCrossRef
41.
Maskrey BH, Megson IL, Rossi AG, Whitfield PD (2013) Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis. Mol Nutr Food Res 57(8):1390–1400PubMedCrossRef
42.
Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R et al (2017) Heart disease and stroke statistics-2017 update a report from the American Heart Association. Circulation 135(10):E146–E603PubMedCrossRef
43.
Cannon CP (2007) Cardiovascular disease and modifiable cardiometabolic risk factors. Clin Cornerstone 8(3):11–28PubMedCrossRef
44.
Mozaffarian D, Appel LJ, Van Horn L (2011) Components of a cardioprotective diet new insights. Circulation 123(24):2870–2891PubMedCrossRef
45.
Saravanan P, Davidson NC, Schmidt EB, Calder PC (2010) Cardiovascular effects of marine omega-3 fatty acids. Lancet 376(9740):540–550PubMedCrossRef
46.
Cunnane S, Drevon C, Harris W, Sinclair A, Spector A (2004) Recommendations for intakes of polyunsaturated fatty acids in healthy adults. ISSFAL Newsl 11(2):12–25
47.
48.
Kris-Etherton PM, Harris WS, Appel LJ, Nutrition C (2002) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106(21):2747–2757PubMedCrossRef
49.
Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ (2008) Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 197(1):12–24PubMedCrossRef
50.
Mozaffarian D, Wu JHY (2011) Omega-3 fatty acids and cardiovascular disease effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 58(20):2047–2067PubMedCrossRef
51.
Huang CW, Chien YS, Chen YJ, Ajuwon KM, Mersmann HM, Ding ST (2016) Role of n-3 polyunsaturated fatty acids in ameliorating the obesity-induced metabolic syndrome in animal models and humans. Int J Mol Sci 17(10):29
52.
Lalia AZ, Lanza IR (2016) Insulin-sensitizing effects of omega-3 fatty acids: lost in translation? Nutrients 8(6):24CrossRef
53.
54.
55.
56.
57.
Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G et al (2013) Anti-inflammatory effects of omega-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol 62(3):285–297PubMedPubMedCentralCrossRef
58.
Morin C, Fortin S, Rousseau E (2011) 19,20-EpDPE, a bioactive CYP450 metabolite of DHA monoacyglyceride, decreases Ca<sup>2+</sup> sensitivity in human pulmonary arteries. Am J Physiol Heart Circ Physiol 301(4):H1311–H1318PubMedCrossRef
59.
De Lorgeril M, Salen P, Defaye P, Rabaeus M (2013) Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? BMC medicine. 11(1):5PubMedPubMedCentralCrossRef
60.
Hooper L, Thompson RL, Harrison RA, Summerbell CD, Ness AR, Moore HJ et al (2006) Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 332(7544):752–760PubMedPubMedCentralCrossRef
61.
Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS (2012) Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA 308(10):1024–1033PubMedCrossRef
62.
Bang HO, Dyerberg J (1980) Lipid metabolism and ischemic heart disease in Greenland Eskimos. In: Draper HH (ed) Advances in nutritional research. Springer, Boston, pp 1–22
63.
Burr ML, Gilbert JF, Holliday RM, Elwood PC, Fehily AM, Rogers S et al (1989) Effects of changes in fat, fish and fiber intakes on death and myocardial reinfarction—diet and reinfarction trial (DART). Lancet 2(8666):757–761PubMedCrossRef
64.
Investigators GI-P (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354(9177):447–455CrossRef
65.
Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, Latini R et al (2008) Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 372(9645):1223–1230PubMedCrossRef
66.
Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y et al (2007) Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised openlabel, blinded endpoint analysis. Lancet 369(9567):1090–1098PubMedCrossRef
67.
Kromhout D, Giltay EJ, Geleijnse JM (2010) n-3 fatty acids and cardiovascular events after myocardial infarction. N Engl J Med 363(21):2015–2026PubMedCrossRef
68.
Kromhout D, Geleijnse JM, de Goede J, Griep LMO, Mulder BJM, de Boer MJ et al (2011) n-3 fatty acids, ventricular arrhythmia-related events, and fatal myocardial infarction in postmyocardial infarction patients with diabetes. Diabetes Care 34(12):2515–2520PubMedPubMedCentralCrossRef
69.
Bowen KJ, Harris WS, Kris-Etherton PM (2016) Omega-3 fatty acids and cardiovascular disease: are there benefits? Curr Treat Options Cardiovasc Med 18(11):69PubMedPubMedCentralCrossRef
70.
Harris WS, von Schacky C (2004) The omega-3 index: a new risk factor for death from coronary heart disease? Prev Med 39(1):212–220PubMedCrossRef
71.
72.
Tasevska N, Jiao L, Cross AJ, Kipnis V, Subar AF, Hollenbeck A et al (2012) Sugars in diet and risk of cancer in the NIH-AARP diet and health study. Int J Cancer 130(1):159–169PubMedCrossRef
73.
Yao CH, Fowle-Grider R, Mahieu NG, Liu GY, Chen Y, Wang RC et al (2016) Exogenous fatty acids are the preferred source of membrane lipids in proliferating fibroblasts. Cell Chem Biol 23(4):483–493PubMedPubMedCentralCrossRef
74.
Bergers G, Benjamin LE (2003) Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3(6):401–410PubMedCrossRef
75.
76.
77.
78.
Kelloff G, Hoffman JM, Johnson B, Scher HI, Siegel BA, Cheng EY et al (2005) Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development. Clin Cancer Res 11(8):2785–2808PubMedCrossRef
79.
80.
81.
Menendez JA, Lupu R (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7(10):763–777PubMedCrossRef
82.
Zaidi N, Swinnen JV, Smans K (2012) ATP-citrate lyase: a key player in cancer metabolism. Cancer Res 72(15):3709–3714PubMedCrossRef
83.
Baenke F, Peck B, Miess H, Schulze A (2013) Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Dis Model Mech 6(6):1353–1363PubMedPubMedCentralCrossRef
84.
Miryaghoubzadeh J, Darabi M, Madaen K, Shaaker M, Mehdizadeh A, Hajihosseini R (2013) Tissue fatty acid composition in human urothelial carcinoma. Br J Biomed Sci 70(1):1–5PubMedCrossRef
85.
Jurczyszyn A, Czepiel J, Gdula-Argasinska J, Pasko P, Czapkiewicz A, Librowski T et al (2015) Plasma fatty acid profile in multiple myeloma patients. Leuk Res 39(4):400–405PubMedCrossRef
86.
Mohammadzadeh F, Mosayebi G, Montazeri V, Darabi M, Fayezi S, Shaaker M et al (2014) Fatty acid composition of tissue cultured breast carcinoma and the effect of stearoyl-CoA desaturase 1 inhibition. J Breast Cancer 17(2):136–142PubMedPubMedCentralCrossRef
87.
Omabe M, Ezeani M, Omabe KN (2015) Lipid metabolism and cancer progression: the missing target in metastatic cancer treatment. J Appl Biomed 13(1):47–59CrossRef
88.
Balaban S, Lee LS, Schreuder M, Hoy AJ (2015) Obesity and cancer progression: is there a role of fatty acid metabolism? Biomed Res Int 2015:1–17CrossRef
89.
Zamaria N (2004) Alteration of polyunsaturated fatty acid status and metabolism in health and disease. Reprod Nutr Dev 44(3):273–282PubMedCrossRef
90.
Gleissman H, Johnsen JI, Kogner P (2010) Omega-3 fatty acids in cancer, the protectors of good and the killers of evil? Exp Cell Res 316(8):1365–1373PubMedCrossRef
91.
Simopoulos AP (2008) The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med. 233(6):674–688CrossRef
92.
93.
Cai W, Zhang K, Li PY, Zhu L, Xu J, Yang BY et al (2017) Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: an aging effect. Ageing Res Rev 34:77–87PubMedCrossRef
94.
95.
96.
Cunnane SC, Plourde M, Pifferi F, Begin M, Feart C, Barberger-Gateau P (2009) Fish, docosahexaenoic acid and Alzheimer’s disease. Prog Lipid Res 48(5):239–256PubMedCrossRef
97.
98.
Torres M, Price SL, Fiol-deRoque MA, Marcilla-Etxenike A, Ahyayauch H, Barcelo-Coblijn G et al (2014) Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer’s disease. Biochim Biophys Acta Biomembr 1838(6):1680–1692CrossRef
99.
100.
Bazan NG (2009) Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins Leukot Essent Fatty Acids 81(2–3):205–211PubMedPubMedCentralCrossRef
101.
McNamara RK, Jandacek R, Rider T, Tso P, Dwivedi Y, Pandey GN (2010) Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. J Affect Disord 126(1–2):303–311PubMedPubMedCentralCrossRef
102.
Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E et al (2010) Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer’s Disease. PLoS ONE 5(9):1–8CrossRef
103.
Nasaruddin ML, Hölscher C, Kehoe P, Graham SF, Green BD (2016) Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer’s disease as detected by GC–MS. Am J Transl Res 8(1):154–165PubMedPubMedCentral
104.
Cunnane SC, Schneider JA, Tangney C, Tremblay-Mercier J, Fortier M, Bennett DA et al (2012) Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis 29(3):691–697PubMedPubMedCentral
105.
Shahar DR, Schwarzfuchs D, Fraser D, Vardi H, Thiery J, Fiedler GM et al (2010) Dairy calcium intake, serum vitamin D, and successful weight loss. Am J Clin Nutr 92(5):1017–1022PubMedCrossRef
106.
Dyall SC (2015) Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci 7:52PubMedPubMedCentralCrossRef
107.
Samieri C, Maillard P, Crivello F, Proust-Lima C, Peuchant E, Helmer C et al (2012) Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe. Neurology 79(7):642–650PubMedCrossRef
108.
Heppner FL, Ransohoff RM, Becher B (2015) Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci 16(6):358–372PubMedCrossRef
109.
Heras-Sandoval D, Pedraza-Chaverri J, Perez-Rojas JM (2016) Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer’s disease. J Neuroinflamm 13:61CrossRef
110.
Hashimoto M, Shahdat HM, Yamashita S, Katakura M, Tanabe Y, Fujiwara H et al (2008) Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer’s disease model rats. J Neurochem 107(6):1634–1646PubMedCrossRef
111.
Grimm MOW, Mett J, Stahlmann CP, Haupenthal VJ, Blumel T, Stotzel H et al (2016) Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-beta by affecting insulin-degrading enzyme. Biochem Cell Biol 94(6):534–542PubMedCrossRef
112.
Morgese MG, Tucci P, Mhillaj E, Bove M, Schiavone S, Trabace L et al (2017) Lifelong nutritional omega-3 deficiency evokes depressive-like state through soluble beta amyloid. Mol Neurobiol 54(3):2079–2089PubMedCrossRef
113.
Colaianna M, Tucci P, Zotti M, Morgese MG, Schiavone S, Govoni S et al (2010) Soluble β amyloid1-42: a critical player in producing behavioural and biochemical changes evoking depressive-related state? Br J Pharmacol 159(8):1704–1715PubMedPubMedCentralCrossRef
114.
115.
Pomara N, Bruno D (2016) Major depression may lead to elevations in potentially neurotoxic amyloid beta species independently of Alzheimer Disease. Am J Geriatr Psychiatr 24(9):773–775CrossRef
116.
Hashimoto M, Katakura M, Hossain S, Rahman A, Shimada T, Shido O (2011) Docosahexaenoic acid withstands the a beta(25-35)-induced neurotoxicity in SH-SY5Y cells. J Nutr Biochem 22(1):22–29PubMedCrossRef
117.
Ledo JH, Azevedo EP, Clarke JR, Ribeiro FC, Figueiredo CP, Foguel D et al (2013) Amyloid-beta oligomers link depressive-like behavior and cognitive deficits in mice. Mol Psychiatr 18(10):1053–1054CrossRef
118.
Ren HX, Luo CM, Feng YQ, Yao XL, Shi Z, Liang FY et al (2017) Omega-3 polyunsaturated fatty acids promote amyloid-beta clearance from the brain through mediating the function of the glymphatic system. Faseb J 31(1):282–293PubMedCrossRef
119.
Oster T, Pillot T (2010) Docosahexaenoic acid and synaptic protection in Alzheimer’s disease mice. Biochim Biophys Acta Mol Cell Biol Lipids 1801(8):791–798CrossRef
120.
Bazan NG (2009) Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer’s disease. J Lipid Res 50(Suppl):400–405CrossRef
121.
Goetz CG (2011) The history of Parkinson’s disease: early clinical descriptions and neurological therapies. Cold Spring Harb Perspect Med 1:1CrossRef
122.
Vinot N, Jouin M, Lhomme-Duchadeuil A, Guesnet P, Alessandri JM, Aujard F et al (2011) Omega-3 Fatty acids from fish oil lower anxiety, improve cognitive functions and reduce spontaneous locomotor activity in a non-human primate. PLoS ONE 6:6CrossRef
123.
Bousquet M, Saint-Pierre M, Julien C, Salem N, Cicchetti F, Calon F (2008) Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson’s disease. Faseb J 22(4):1213–1225PubMedCrossRef
124.
Ozkan A, Parlak H, Tanriover G, Dilmac S, Ulker SN, Birsen L et al (2016) The protective mechanism of docosahexaenoic acid in mouse model of Parkinson: the role of heme oxygenase. Neurochem Int 101:110–119CrossRef
125.
Bousquet M, Gue K, Emond V, Julien P, Kang JX, Cicchetti F et al (2011) Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson’s disease. J Lipid Res 52(2):263–271PubMedPubMedCentralCrossRef
126.
Ozsoy O, Seval-Celik Y, Hacioglu G, Yargicoglu P, Demir R, Agar A et al (2011) The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson’s disease. Neurochem Int 59(5):664–670PubMedCrossRef
127.
Pomponi M, Loria G, Salvati S, Di Biase A, Conte G, Villella C et al (2014) DHA effects in Parkinson disease depression. Basal Ganglia 4(2):61–66CrossRef
128.
da Silva TM, Munhoz RP, Alvarez C, Naliwaiko K, Kiss A, Andreatini R et al (2008) Depression in Parkinson’s disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation. J Affect Disord 111(2–3):351–359PubMedCrossRef
129.
Darios F, Davletov B (2006) Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Nature 440(7085):813–817PubMedCrossRef
130.
Chytrova G, Ying Z, Gomez-Pinilla F (2010) Exercise contributes to the effects of DHA dietary supplementation by acting on membrane-related synaptic systems. Brain Res 1341:32–40PubMedCrossRef
131.
Alessandri J-M, Guesnet P, Vancassel S, Astorg P, Denis I, Langelier B et al (2004) Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life. Reprod Nutr Dev 44(6):509–538PubMedCrossRef
132.
Arima H, Omura T, Hayasaka T, Masaki N, Hanada M, Xu D et al (2015) Reductions of docosahexaenoic acid-containing phosphatidylcholine levels in the anterior horn of and ALS mouse model. Neuroscience 297:127–136PubMedCrossRef
133.
Ilieva EV, Ayala V, Jové M, Dalfó E, Cacabelos D, Povedano M et al (2007) Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis. Brain 130(12):3111–3123PubMedCrossRef
134.
Ayala V, Granado-Serrano AB, Cacabelos D, Naudi A, Ilieva EV, Boada J et al (2011) Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS. Acta Neuropathol 122(3):259–270PubMedCrossRef
135.
Cacabelos D, Ayala V, Granado-Serrano AB, Jove M, Torres P, Boada J et al (2016) Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis. Neurobiol Dis 88:148–160PubMedCrossRef
136.
Fitzgerald KC, O’Reilly ÉJ, Falcone GJ et al (2014) Dietary ω-3 polyunsaturated fatty acid intake and risk for amyotrophic lateral sclerosis. JAMA Neurol 71(9):1102–1110PubMedPubMedCentralCrossRef
137.
Pettit LK, Varsanyi C, Tadros J, Vassiliou E (2013) Modulating the inflammatory properties of activated microglia with docosahexaenoic acid and aspirin. Lipids Health Dis 12:16PubMedPubMedCentralCrossRef
138.
Yip PK, Pizzasegola C, Gladman S, Biggio ML, Marino M, Jayasinghe M et al (2013) The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis. PLoS ONE 8:17
139.
Shibata N, Yamada S, Uchida K, Hirano A, Sakoda S, Fujimura H et al (2004) Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis. Brain Res 1019(1–2):170–177PubMedCrossRef
140.
Siriwardhana N, Kalupahana NS, Moustaid-Moussa N (2012) Health benefits of n-3 polyunsaturated fatty acids: eicosapentaenoic acid and docosahexaenoic acid. In: Kim SK (ed) Advances in food and nutrition research, vol 65 implications and applications—animals and microbes. Elsevier Academic Press Inc, San Diego, pp 211–222
141.
Hussein JS (2013) Cell membrane fatty acids and health. Int J Pharm Pharm Sci. 5(3):38–46
142.
Simopoulos AP (2013) Dietary omega-3 fatty acid deficiency and high fructose intake in the development of metabolic syndrome, brain metabolic abnormalities, and non-alcoholic fatty liver disease. Nutrients 5(8):2901–2923PubMedPubMedCentralCrossRef
143.
144.
Domenichiello AF, Kitson AP, Bazinet RP (2015) Is docosahexaenoic acid synthesis from a-linolenic acid sufficient to supply the adult brain? Prog Lipid Res 59:54–66PubMedCrossRef
145.
Global Organization for EPA and DHA Omega-3s (2015) Global recommendations for EPA and DHA intake. p. 17
146.
FAO (2010) Fats and fatty acids in human nutrition. Report of an expert consultation. FAO Food Nutr Pap 1:1–166
147.
Authority EFS (2010) Scientific opinion on dietary reference values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. EFSA J 8(3):1461CrossRef
148.
Kus-Yamashita MMM, Mcdonald B, Ravacci G, Rogero MM, Santos RD, Waitzberg D et al (2016) Polyunsaturated fatty acids: health impacts. Eur J Nutr Food Saf 6(3):111–131CrossRef
149.
Jensen CL (2006) Effects of n-3 fatty acids during pregnancy and lactation. Am J Clin Nutr 83(Suppl):1452–1457
150.
Koletzko B, Cetin I, Brenna JT, Grp P (2007) Dietary fat intakes for pregnant and lactating women. Br J Nutr 98(5):873–877PubMedCrossRef
151.
Morgese M, Trabace L (2016) Maternal malnutrition in the etiopathogenesis of psychiatric diseases: role of polyunsaturated fatty acids. Brain Sci 6(3):24PubMedCentralCrossRef
152.
Sanders TAB, Reddy S (1992) The influence of a vegetarian diet on the fatty-acid composition of human-milk and the essential fatty-acid status of the infant. J Pediatr 120(Suppl):71–77CrossRef
153.
The State of World Fisheries and Aquaculture (2016) Contributing to food security and nutrition for all. FAO
154.
Zárate R, el Jaber-Vazdekis N, Ramírez-Moreno R (2016) Importance of polyunsaturated fatty acids from marine algae. In: Hegde MV, Zanwar AA, Adekar SP (eds) Omega-3 fatty acids: keys to nutritional health. Springer International Publishing, Cham, pp 101–126CrossRef
Metadata
Title
Significance of long chain polyunsaturated fatty acids in human health
Authors
Rafael Zárate
Nabil el Jaber-Vazdekis
Noemi Tejera
José A. Pérez
Covadonga Rodríguez
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2017
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/s40169-017-0153-6

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