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Clinical and Translational Medicine
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Open Access 01-12-2017 | Review

Anthracycline induced cardiotoxicity: biomarkers and “Omics” technology in the era of patient specific care

Authors: Shayan Moazeni, Martin Cadeiras, Eric H. Yang, Mario C. Deng, Kim-Lien Nguyen

Published in: Clinical and Translational Medicine | Issue 1/2017

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Abstract

Anthracyclines are highly effective against a variety of malignancies. However, their dose-dependent cardiotoxic effects can potentially limit their use. In the past decade, serum biomarkers have been used to diagnose, monitor, predict, and prognosticate disease. Biomarkers such as cardiac troponin and natriuretic peptides have some predictive value, but still lack reliability in this patient population. Novel biomarkers such as galectin-3, soluble ST-2 proteins, myeloperoxidase, and fibrocytes are being explored as potential biomarkers to reliably predict the onset of cardiotoxicity. Leveraging multiomics technology to map highly sensitive biomarkers in an integrated approach through pattern deconvolution may better define those at highest risk of developing cardiotoxicity and further the goal of precision medicine. In this work, we aim to provide a brief overview of traditional serum biomarkers, summarize current investigations on novel circulating biomarkers, and discuss a systems-based approach to anthracycline-induced cardiotoxicity through “omics” technology.
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Metadata
Title
Anthracycline induced cardiotoxicity: biomarkers and “Omics” technology in the era of patient specific care
Authors
Shayan Moazeni
Martin Cadeiras
Eric H. Yang
Mario C. Deng
Kim-Lien Nguyen
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2017
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/s40169-017-0148-3

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