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01-12-2021 | Repetitive Transcranial Magnetic Stimulation | Protocol

Effects of non-invasive brain stimulation in children and young people with psychiatric disorders: a protocol for a systematic review

Authors: Yael D. Lewis, Lucy Gallop, Iain C. Campbell, Ulrike Schmidt

Published in: Systematic Reviews | Issue 1/2021

Abstract

Background

Most psychiatric disorders have their onset in childhood or adolescence, and if not fully treated have the potential for causing life-long psycho-social and physical sequelae. Effective psychotherapeutic and medication treatments exist, but a significant proportion of children and young people do not make a full recovery. Thus, novel, safe, brain-based alternatives or adjuncts to conventional treatments are needed. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation (NIBS) techniques which have shown clinical benefits in adult psychiatric conditions. However, in children and young people their efficacy is not well established. The objective of this study will be to systematically evaluate the evidence on clinical effects of NIBS in children and young people with psychiatric disorders, assessing disorder-specific symptoms, mood and neurocognitive functions.

Methods

We designed and registered a study protocol for a systematic review. We will include randomised and non-randomised controlled trials and observational studies (e.g. cohort, case-control, case series) assessing the effects of NIBS in children and young people (aged ≤ 24 years old) for psychiatric disorders. The primary outcome will be reduction of disorder-specific symptoms. Secondary outcomes will include effects on mood and cognition. A comprehensive search from database inception onwards will be conducted in MEDLINE, EMBASE and PsycINFO. Grey literature will be identified through searching multiple clinical trial registries. Two reviewers will independently screen all citations, full-text articles and abstract data. The methodological quality of the studies will be appraised using appropriate tools. We will provide a narrative synthesis of the evidence and according to heterogeneity will conduct an appropriate meta-analysis. Additional analyses will be conducted to explore the potential sources of heterogeneity.

Discussion

This systematic review will provide a broad and comprehensive evaluation of the evidence on clinical effects of NIBS in children and young people with psychiatric disorders. Our findings will be reported according to the PRISMA guidelines and will be of interest to multiple audiences (including patients, researchers, healthcare professionals and policy-makers). Results will be published in a peer-reviewed journal.

Systematic review registration

PROSPERO CRD42019158957

Available only for authorised users

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Title: Effects of non-invasive brain stimulation in children and young people with psychiatric disorders: a protocol for a systematic review
Authors: Yael D. Lewis
Lucy Gallop
Iain C. Campbell
Ulrike Schmidt
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Repetitive Transcranial Magnetic Stimulation
Nerve Stimulation
Published in: Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-021-01627-3

At a glance: The STEP trials

Springer Medicine

Effects of non-invasive brain stimulation in children and young people with psychiatric disorders: a protocol for a systematic review

Abstract

Background

Methods

Discussion

Systematic review registration

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Discussion

Systematic review registration

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