Skip to main content
Top
Published in: Annals of Intensive Care 1/2019

Open Access 01-12-2019 | Acute Kidney Injury | Editorial

Renal protection in sepsis: Is hypertonic sodium (lactate) the solution?

Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Herbert D. Spapen

Published in: Annals of Intensive Care | Issue 1/2019

Login to get access

Excerpt

Hypertonic sodium solutions are useful for minimizing secondary brain injury from cerebral edema but also attractive for “small-volume” resuscitation in severe hypovolemia and shock because they rapidly mobilize endogenous water from the intracellular reservoir, thereby reducing endothelial cell volume and restoring microcirculation. …
Literature
1.
go back to reference Duburcq T, Durand A, Tournoys A, Gnemmi V, Gmyr V, Pattou F, et al. Sodium lactate improves renal microvascular thrombosis compared to sodium bicarbonate and 0.9% NaCl in a porcine model of endotoxic shock: an experimental randomized open label controlled study. Ann Intensive Care. 2018;8(1):24.CrossRef Duburcq T, Durand A, Tournoys A, Gnemmi V, Gmyr V, Pattou F, et al. Sodium lactate improves renal microvascular thrombosis compared to sodium bicarbonate and 0.9% NaCl in a porcine model of endotoxic shock: an experimental randomized open label controlled study. Ann Intensive Care. 2018;8(1):24.CrossRef
2.
go back to reference Hariri G, Joffre J, Deryckere S, Bigé N, Dumas G, Baudel J-L, et al. Albumin infusion improves endothelial function in septic shock patients: a pilot study. Intensive Care Med. 2018;44(5):669–71.CrossRef Hariri G, Joffre J, Deryckere S, Bigé N, Dumas G, Baudel J-L, et al. Albumin infusion improves endothelial function in septic shock patients: a pilot study. Intensive Care Med. 2018;44(5):669–71.CrossRef
3.
go back to reference Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA. 2012;308(15):1566–72.CrossRef Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA. 2012;308(15):1566–72.CrossRef
4.
go back to reference Chowdhury AH, Cox EF, Francis ST, Lobo DN. A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and plasma-lyte® 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. Ann Surg. 2012;256:18–24.CrossRef Chowdhury AH, Cox EF, Francis ST, Lobo DN. A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and plasma-lyte® 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. Ann Surg. 2012;256:18–24.CrossRef
5.
go back to reference Krajewski ML, Raghunathan K, Paluszkiewicz SM, Schermer CR, Shaw AD. Meta-analysis of high-versus low-chloride content in perioperative and critical care fluid resuscitation. Br J Surg. 2015;102:24–36.CrossRef Krajewski ML, Raghunathan K, Paluszkiewicz SM, Schermer CR, Shaw AD. Meta-analysis of high-versus low-chloride content in perioperative and critical care fluid resuscitation. Br J Surg. 2015;102:24–36.CrossRef
6.
go back to reference Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, et al. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial. JAMA. 2015;314:1701–10.CrossRef Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, et al. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial. JAMA. 2015;314:1701–10.CrossRef
7.
go back to reference Semler MW, Wanderer JP, Ehrenfeld JM, Stollings JL, Self WH, Siew ED, et al. SALT Investigators and the Pragmatic Critical Care Research Group. Balanced crystalloids versus saline in the intensive care unit: the SALT randomized trial. Am J Respir Crit Care Med. 2017;195(10):1362–72.CrossRef Semler MW, Wanderer JP, Ehrenfeld JM, Stollings JL, Self WH, Siew ED, et al. SALT Investigators and the Pragmatic Critical Care Research Group. Balanced crystalloids versus saline in the intensive care unit: the SALT randomized trial. Am J Respir Crit Care Med. 2017;195(10):1362–72.CrossRef
8.
go back to reference Zampieri FG, Ranzani OT, Azevedo LC, Martins ID, Kellum JA, Libório AB. Lactated Ringer is associated with reduced mortality and less acute kidney injury in critically ill patients: a retrospective cohort analysis. Crit Care Med. 2016;44:2163–70.CrossRef Zampieri FG, Ranzani OT, Azevedo LC, Martins ID, Kellum JA, Libório AB. Lactated Ringer is associated with reduced mortality and less acute kidney injury in critically ill patients: a retrospective cohort analysis. Crit Care Med. 2016;44:2163–70.CrossRef
9.
go back to reference Pfortmueller CA, Schefold JC. Hypertonic saline in critical illness—a systematic review. J Crit Care. 2017;42:168–77.CrossRef Pfortmueller CA, Schefold JC. Hypertonic saline in critical illness—a systematic review. J Crit Care. 2017;42:168–77.CrossRef
10.
go back to reference Nalos M, Leverve X, Huang S, Weisbrodt L, Parkin R, Seppelt I, et al. Half-molar sodium lactate infusion improves cardiac performance in acute heart failure: a pilot randomised controlled clinical trial. Crit Care. 2014;18(2):R48.CrossRef Nalos M, Leverve X, Huang S, Weisbrodt L, Parkin R, Seppelt I, et al. Half-molar sodium lactate infusion improves cardiac performance in acute heart failure: a pilot randomised controlled clinical trial. Crit Care. 2014;18(2):R48.CrossRef
11.
go back to reference Jaber S, Paugam C, Futier E, Lefrant JY, Lasocki S, Lescot T, et al. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet. 2018;392(10141):31–40.CrossRef Jaber S, Paugam C, Futier E, Lefrant JY, Lasocki S, Lescot T, et al. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet. 2018;392(10141):31–40.CrossRef
12.
go back to reference Asfar P, Schortgen F, Boisramé-Helms J, Charpentier J, Guérot E, Megarbane B, et al. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial. Lancet Respir Med. 2017;5(3):180–90.CrossRef Asfar P, Schortgen F, Boisramé-Helms J, Charpentier J, Guérot E, Megarbane B, et al. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial. Lancet Respir Med. 2017;5(3):180–90.CrossRef
13.
go back to reference Duburcq T, Durand A, Dessein AF, Vamecq J, Vienne JC, Dobbelaere D, et al. Comparison of fluid balance and hemodynamic and metabolic effects of sodium lactate versus sodium bicarbonate versus 0.9% NaCl in porcine endotoxic shock: a randomized, open-label, controlled study. Crit Care. 2017;21(1):113.CrossRef Duburcq T, Durand A, Dessein AF, Vamecq J, Vienne JC, Dobbelaere D, et al. Comparison of fluid balance and hemodynamic and metabolic effects of sodium lactate versus sodium bicarbonate versus 0.9% NaCl in porcine endotoxic shock: a randomized, open-label, controlled study. Crit Care. 2017;21(1):113.CrossRef
14.
go back to reference Van Regenmortel N, Verbrugghe W, Roelant E, Van den Wyngaert T, Jorens PG. Maintenance fluid therapy and fluid creep impose more significant fluid, sodium, and chloride burdens than resuscitation fluids in critically ill patients: a retrospective study in a tertiary mixed ICU population. Intensive Care Med. 2018;44(4):409–17.CrossRef Van Regenmortel N, Verbrugghe W, Roelant E, Van den Wyngaert T, Jorens PG. Maintenance fluid therapy and fluid creep impose more significant fluid, sodium, and chloride burdens than resuscitation fluids in critically ill patients: a retrospective study in a tertiary mixed ICU population. Intensive Care Med. 2018;44(4):409–17.CrossRef
15.
go back to reference Su F, Xie K, He X, Orbegozo D, Hosokawa K, Post EH, et al. The harmful effects of hypertonic sodium lactate administration in hyperdynamic septic shock. Shock. 2016;46(6):663–71.CrossRef Su F, Xie K, He X, Orbegozo D, Hosokawa K, Post EH, et al. The harmful effects of hypertonic sodium lactate administration in hyperdynamic septic shock. Shock. 2016;46(6):663–71.CrossRef
Metadata
Title
Renal protection in sepsis: Is hypertonic sodium (lactate) the solution?
Authors
Patrick M. Honore
Leonel Barreto Gutierrez
Herbert D. Spapen
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Annals of Intensive Care / Issue 1/2019
Electronic ISSN: 2110-5820
DOI
https://doi.org/10.1186/s13613-019-0505-z

Other articles of this Issue 1/2019

Annals of Intensive Care 1/2019 Go to the issue