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Annals of Intensive Care
Published in: Annals of Intensive Care 1/2019

Open Access 01-12-2019 | Bronchial Asthma | Review

Management of severe asthma exacerbation: guidelines from the Société Française de Médecine d’Urgence, the Société de Réanimation de Langue Française and the French Group for Pediatric Intensive Care and Emergencies

Authors: Philippe Le Conte, Nicolas Terzi, Guillaume Mortamet, Fekri Abroug, Guillaume Carteaux, Céline Charasse, Anthony Chauvin, Xavier Combes, Stéphane Dauger, Alexandre Demoule, Thibaut Desmettre, Stephan Ehrmann, Bénédicte Gaillard-Le Roux, Valérie Hamel, Boris Jung, Sabrina Kepka, Erwan L’Her, Mikaël Martinez, Christophe Milési, Élise Morawiec, Mathieu Oberlin, Patrick Plaisance, Robin Pouyau, Chantal Raherison, Patrick Ray, Mathieu Schmidt, Arnaud W. Thille, Jennifer Truchot, Guillaume Valdenaire, Julien Vaux, Damien Viglino, Guillaume Voiriot, Bénédicte Vrignaud, Sandrine Jean, Eric Mariotte, Pierre-Géraud Claret

Published in: Annals of Intensive Care | Issue 1/2019

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Abstract

Background

The French Emergency Medicine Society, the French Intensive Care Society and the Pediatric Intensive Care and Emergency Medicine French-Speaking Group edited guidelines on severe asthma exacerbation (SAE) in adult and pediatric patients.

Results

The guidelines were related to 5 areas: diagnosis, pharmacological treatment, oxygen therapy and ventilation, patients triage, specific considerations regarding pregnant women. The literature analysis and formulation of the guidelines were conducted according to the Grade of Recommendation Assessment, Development and Evaluation methodology. An extensive literature research was conducted based on publications indexed in PubMed™ and Cochrane™ databases. Of the 21 formalized guidelines, 4 had a high level of evidence (GRADE 1+/−) and 7 a low level of evidence (GRADE 2+/−). The GRADE method was inapplicable to 10 guidelines, which resulted in expert opinions. A strong agreement was reached for all guidelines.

Conclusion

The conjunct work of 36 experts from 3 scientific societies resulted in 21 formalized recommendations to help improving the emergency and intensive care management of adult and pediatric patients with SAE.
Literature
1.
2.
Raherison C, Bourdin A, Bonniaud P, Deslée G, Garcia G, Leroyer C, Taillé C, De Blic J, Dubus J-C, Tillié-Leblond I, Chanez P. Updated guidelines (2015) for management and monitoring of adult and adolescent asthmatic patients (from 12 years and older) of the Société de Pneumologie de Langue Française (SPLF) (Full length text). Rev Mal Respir. 2016;33:279–325.PubMedCrossRef
3.
Fuhlbrigge A, Peden D, Apter AJ, Boushey HA, Camargo CA, Gern J, Heymann PW, Martinez FD, Mauger D, Teague WG, Blaisdell C. Asthma outcomes: Exacerbations. J Allergy Clin Immunol. 2012;129:S34–48.PubMedPubMedCentralCrossRef
4.
Chan-Yeung M, Chang JH, Manfreda J, Ferguson A, Becker A. Changes in peak flow, symptom score, and the use of medications during acute exacerbations of asthma. Am J Respir Crit Care Med. 1996;154:889–93.PubMedCrossRef
5.
6.
Ichinose M, Sugiura H, Nagase H, Yamaguchi M, Inoue H, Sagara H, Tamaoki J, Tohda Y, Munakata M, Yamauchi K, Ohta K, Japanese Society of Allergology. Japanese guidelines for adult asthma 2017. Allergol Int. 2017;66:163–89.PubMedCrossRef
7.
Salmeron S, Liard R, Elkharrat D, Muir J, Neukirch F, Ellrodt A. Asthma severity and adequacy of management in accident and emergency departments in France: a prospective study. Lancet. 2001;358:629–35.PubMedCrossRef
8.
Alvarez GG, Schulzer M, Jung D, Fitzgerald JM. A systematic review of risk factors associated with near-fatal and fatal asthma. Can Respir J. 2005;12:265–70.PubMedCrossRef
9.
Spitzer WO, Suissa S, Ernst P, Horwitz RI, Habbick B, Cockcroft D, Boivin JF, McNutt M, Buist AS, Rebuck AS. The use of beta-agonists and the risk of death and near death from asthma. N Engl J Med. 1992;326:501–6.PubMedCrossRef
10.
Alvarez GG, Fitzgerald JM. A systematic review of the psychological risk factors associated with near fatal asthma or fatal asthma. Respiration. 2007;74:228–36.PubMedCrossRef
11.
Sturdy PM, Victor CR, Anderson HR, Bland JM, Butland BK, Harrison BDW, Peckitt C, Taylor JC, Mortality and Severe Morbidity Working Group of the National Asthma Task Force. Psychological, social and health behaviour risk factors for deaths certified as asthma: a national case-control study. Thorax. 2002;57:1034–9.PubMedPubMedCentralCrossRef
12.
Gupta D, Keogh B, Chung KF, Ayres JG, Harrison DA, Goldfrad C, Brady AR, Rowan K. Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care. 2004;8:R112–21.PubMedPubMedCentralCrossRef
13.
Afessa B, Morales I, Cury JD. Clinical course and outcome of patients admitted to an ICU for status asthmaticus. Chest. 2001;120:1616–21.PubMedCrossRef
14.
Hasegawa W, Yamauchi Y, Yasunaga H, Takeshima H, Sakamoto Y, Jo T, Sasabuchi Y, Matsui H, Fushimi K, Nagase T. Prognostic nomogram for inpatients with asthma exacerbation. BMC Pulm Med. 2017;17:108.PubMedPubMedCentralCrossRef
15.
Weber EJ, Silverman RA, Callaham ML, Pollack CV, Woodruff PG, Clark S, Camargo CA. A prospective multicenter study of factors associated with hospital admission among adults with acute asthma. Am J Med. 2002;113:371–8.PubMedCrossRef
16.
Turner MO, Noertjojo K, Vedal S, Bai T, Crump S, Fitzgerald JM. Risk factors for near-fatal asthma. A case-control study in hospitalized patients with asthma. Am J Respir Crit Care Med. 1998;157:1804–9.PubMedCrossRef
17.
McDowell KM, Kercsmar CM, Huang B, Guilbert TW, Kahn RS. Medical and Social Determinants of Health Associated with Intensive Care Admission for Asthma in Children. Ann Am Thorac Soc. 2016;13:1081–8.PubMedPubMedCentralCrossRef
18.
Mitchell I, Tough SC, Semple LK, Green FH, Hessel PA. Near-fatal asthma: a population-based study of risk factors. Chest. 2002;121:1407–13.PubMedCrossRef
19.
Belessis Y, Dixon S, Thomsen A, Duffy B, Rawlinson W, Henry R, Morton J. Risk factors for an intensive care unit admission in children with asthma. Pediatr Pulmonol. 2004;37:201–9.PubMedCrossRef
20.
Tsai TW, Gallagher EJ, Lombardi G, Gennis P, Carter W. Guidelines for the selective ordering of admission chest radiography in adult obstructive airway disease. Ann Emerg Med. 1993;22:1854–8.PubMedCrossRef
21.
22.
Kelly A-M, Kerr D, Middleton P. Validation of venous pCO2 to screen for arterial hypercarbia in patients with chronic obstructive airways disease. J Emerg Med. 2005;28:377–9.PubMedCrossRef
23.
Dankoff S, Li P, Shapiro AJ, Varshney T, Dubrovsky AS. Point of care lung ultrasound of children with acute asthma exacerbations in the pediatric ED. Am J Emerg Med. 2017;35:615–22.PubMedCrossRef
24.
Shrestha M, Bidadi K, Gourlay S, Hayes J. Continuous vs intermittent albuterol, at high and low doses, in the treatment of severe acute asthma in adults. Chest. 1996;110:42–7.PubMedCrossRef
25.
Rudnitsky GS, Eberlein RS, Schoffstall JM, Mazur JE, Spivey WH. Comparison of intermittent and continuously nebulized albuterol for treatment of asthma in an urban emergency department. Ann Emerg Med. 1993;22:1842–6.PubMedCrossRef
26.
27.
28.
Khine H, Fuchs SM, Saville AL. Continuous vs intermittent nebulized albuterol for emergency management of asthma. Acad Emerg Med. 1996;3:1019–24.PubMedCrossRef
29.
Kenyon CC, Fieldston ES, Luan X, Keren R, Zorc JJ. Safety and effectiveness of continuous aerosolized albuterol in the non-intensive care setting. Pediatrics. 2014;134:e976–82.PubMedCrossRef
30.
Lanes SF, Garrett JE, Wentworth CE, Fitzgerald JM, Karpel JP. The effect of adding ipratropium bromide to salbutamol in the treatment of acute asthma: a pooled analysis of three trials. Chest. 1998;114:365–72.PubMedCrossRef
31.
Rodrigo G, Rodrigo C, Burschtin O. A meta-analysis of the effects of ipratropium bromide in adults with acute asthma. Am J Med. 1999;107:363–70.PubMedCrossRef
32.
Stoodley RG, Aaron SD, Dales RE. The role of ipratropium bromide in the emergency management of acute asthma exacerbation: a metaanalysis of randomized clinical trials. Ann Emerg Med. 1999;34:8–18.PubMedCrossRef
33.
Kirkland SW, Vandenberghe C, Voaklander B, Nikel T, Campbell S, Rowe BH. Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma. Cochrane Database Syst Rev. 2017;1:CD001284.PubMed
34.
35.
Britton J, Hanley SP, Garrett HV, Hadfield JW, Tattersfield AE. Dose related effects of salbutamol and ipratropium bromide on airway calibre and reactivity in subjects with asthma. Thorax. 1988;43:300–5.PubMedPubMedCentralCrossRef
36.
37.
Edmonds ML, Milan SJ, Brenner BE, Camargo CA, Rowe BH. Inhaled steroids for acute asthma following emergency department discharge. Cochrane Database Syst Rev. 2012;12:CD002316.PubMed
38.
39.
Schuh S, Reisman J, Alshehri M, Dupuis A, Corey M, Arseneault R, Alothman G, Tennis O, Canny G. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. N Engl J Med. 2000;343:689–94.PubMedCrossRef
40.
Devidayal, Singhi S, Kumar L, Jayshree M. Efficacy of nebulized budesonide compared to oral prednisolone in acute bronchial asthma. Acta Paediatr. 1999;88:835–40.PubMedCrossRef
41.
Ancheta VA, Jiao AGQ, Erguiza GSD, Arellano MA, Dizon CC, Catacutan MS. comparison of inhaled fluticasone propionate versus intravenous hydrocortisone in the treatment of severe asthma exacerbation in children aged 6–18 years. Chest. 2008;134:24S.CrossRef
42.
Matthews EE, Curtis PD, McLain BI, Morris LS, Turbitt ML. Nebulized budesonide versus oral steroid in severe exacerbations of childhood asthma. Acta Paediatr. 1999;88:841–3.PubMedCrossRef
43.
Beckhaus AA, Riutort MC, Castro-Rodriguez JA. Inhaled versus systemic corticosteroids for acute asthma in children. A systematic review. Pediatr Pulmonol. 2014;49:326–34.PubMedCrossRef
44.
Goodacre S, Cohen J, Bradburn M, Stevens J, Gray A, Benger J, Coats T, 3Mg Research Team. The 3 Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma. Health Technol Assess. 2014;18:1–168.PubMedPubMedCentralCrossRef
45.
Skobeloff EM, Spivey WH, McNamara RM, Greenspon L. Intravenous magnesium sulfate for the treatment of acute asthma in the emergency department. JAMA. 1989;262:1210–3.PubMedCrossRef
46.
Mangat HS, D’Souza GA, Jacob MS. Nebulized magnesium sulphate versus nebulized salbutamol in acute bronchial asthma: a clinical trial. Eur Respir J. 1998;12:341–4.PubMedCrossRef
47.
Bloch H, Silverman R, Mancherje N, Grant S, Jagminas L, Scharf SM. Intravenous magnesium sulfate as an adjunct in the treatment of acute asthma. Chest. 1995;107:1576–81.PubMedCrossRef
48.
Egelund TA, Wassil SK, Edwards EM, Linden S, Irazuzta JE. High-dose magnesium sulfate infusion protocol for status asthmaticus: a safety and pharmacokinetics cohort study. Intensive Care Med. 2013;39:117–22.PubMedCrossRef
49.
50.
Mohammed S, Goodacre S. Intravenous and nebulised magnesium sulphate for acute asthma: systematic review and meta-analysis. Emerg Med J. 2007;24:823–30.PubMedPubMedCentralCrossRef
51.
Torres S, Sticco N, Bosch JJ, Iolster T, Siaba A, Rocca Rivarola M, Schnitzler E. Effectiveness of magnesium sulfate as initial treatment of acute severe asthma in children, conducted in a tertiary-level university hospital: a randomized, controlled trial. Arch Argent Pediatr. 2012;110:291–6.PubMed
52.
Shan Z, Rong Y, Yang W, Wang D, Yao P, Xie J, Liu L. Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: a systematic review and meta-analysis. Respir Med. 2013;107:321–30.PubMedCrossRef
53.
Marchello C, Dale AP, Thai TN, Han DS, Ebell MH. Prevalence of atypical pathogens in patients with cough and community-acquired pneumonia: a meta-analysis. Ann Fam Med. 2016;14:552–66.PubMedPubMedCentralCrossRef
54.
Talbot TR, Hartert TV, Mitchel E, Halasa NB, Arbogast PG, Poehling KA, Schaffner W, Craig AS, Griffin MR. Asthma as a risk factor for invasive pneumococcal disease. N Engl J Med. 2005;352:2082–90.PubMedCrossRef
55.
Gielen V, Johnston SL, Edwards MR. Azithromycin induces anti-viral responses in bronchial epithelial cells. Eur Respir J. 2010;36:646–54.PubMedCrossRef
56.
Kobayashi Y, Wada H, Rossios C, Takagi D, Higaki M, Mikura S, Goto H, Barnes PJ, Ito K. A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition. J Pharmacol Exp Ther. 2013;345:76–84.PubMedCrossRef
57.
Johnston SL, Blasi F, Black PN, Martin RJ, Farrell DJ, Nieman RB, Investigators TELICAST. The effect of telithromycin in acute exacerbations of asthma. N Engl J Med. 2006;354:1589–600.PubMedCrossRef
58.
Johnston SL, Szigeti M, Cross M, Brightling C, Chaudhuri R, Harrison T, Mansur A, Robison L, Sattar Z, Jackson D, Mallia P, Wong E, Corrigan C, Higgins B, Ind P, Singh D, Thomson NC, Ashby D, Chauhan A, Trial Team AZALEA. Azithromycin for acute exacerbations of asthma: the AZALEA randomized clinical trial. JAMA Intern Med. 2016;176:1630–7.PubMedCrossRef
59.
Graham VA, Milton AF, Knowles GK, Davies RJ. Routine antibiotics in hospital management of acute asthma. Lancet. 1982;1:418–20.PubMedCrossRef
60.
61.
Rowe BH, Villa-Roel C, Abu-Laban RB, Stenstrom R, Mackey D, Stiell IG, Campbell S, Young B. Admissions to Canadian hospitals for acute asthma: a prospective, multicentre study. Can Respir J. 2010;17:25–30.PubMedPubMedCentralCrossRef
62.
Perrin K, Wijesinghe M, Healy B, Wadsworth K, Bowditch R, Bibby S, Baker T, Weatherall M, Beasley R. Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma. Thorax. 2011;66:937–41.PubMedCrossRef
63.
Rodrigo GJ, Rodriquez Verde M, Peregalli V, Rodrigo C. Effects of short-term 28% and 100% oxygen on PaCO2 and peak expiratory flow rate in acute asthma: a randomized trial. Chest. 2003;124:1312–7.PubMedCrossRef
64.
Chien JW, Ciufo R, Novak R, Skowronski M, Nelson J, Coreno A, McFadden ER. Uncontrolled oxygen administration and respiratory failure in acute asthma. Chest. 2000;117:728–33.PubMedCrossRef
65.
Ganesh A, Shenoy S, Doshi V, Rishi M, Molnar J. Use of noninvasive ventilation in adult patients with acute asthma exacerbation. Am J Ther. 2015;22:431–4.PubMedCrossRef
66.
Fernández MM, Villagrá A, Blanch L, Fernández R. Non-invasive mechanical ventilation in status asthmaticus. Intensive Care Med. 2001;27:486–92.PubMedCrossRef
67.
Murase K, Tomii K, Chin K, Tsuboi T, Sakurai A, Tachikawa R, Harada Y, Takeshima Y, Hayashi M, Ishihara K. The use of non-invasive ventilation for life-threatening asthma attacks: changes in the need for intubation. Respirology. 2010;15:714–20.PubMedCrossRef
68.
Stefan MS, Nathanson BH, Lagu T, Priya A, Pekow PS, Steingrub JS, Hill NS, Goldberg RJ, Kent DM, Lindenauer PK. Outcomes of noninvasive and invasive ventilation in patients hospitalized with asthma exacerbation. Ann Am Thorac Soc. 2016;13:1096–104.PubMedPubMedCentralCrossRef
69.
Soroksky A, Stav D, Shpirer I. A pilot prospective, randomized, placebo-controlled trial of bilevel positive airway pressure in acute asthmatic attack. Chest. 2003;123:1018–25.PubMedCrossRef
70.
Soma T, Hino M, Kida K, Kudoh S. A prospective and randomized study for improvement of acute asthma by non-invasive positive pressure ventilation (NPPV). Intern Med. 2008;47:493–501.PubMedCrossRef
71.
Gupta D, Nath A, Agarwal R, Behera D. A prospective randomized controlled trial on the efficacy of noninvasive ventilation in severe acute asthma. Respir Care. 2010;55:536–43.PubMed
72.
Brandao DC, Lima VM, Filho VG, Silva TS, Campos TF, Dean E, de Andrade AD. Reversal of bronchial obstruction with bi-level positive airway pressure and nebulization in patients with acute asthma. J Asthma. 2009;46:356–61.PubMedCrossRef
73.
Lim WJ, Mohammed Akram R, Carson KV, Mysore S, Labiszewski NA, Wedzicha JA, Rowe BH, Smith BJ. Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma. Cochrane Database Syst Rev. 2012;12:CD004360.PubMed
74.
75.
Thill PJ, McGuire JK, Baden HP, Green TP, Checchia PA. Noninvasive positive-pressure ventilation in children with lower airway obstruction. Pediatr Crit Care Med. 2004;5:337–42.PubMedCrossRef
76.
Basnet S, Mander G, Andoh J, Klaska H, Verhulst S, Koirala J. Safety, efficacy, and tolerability of early initiation of noninvasive positive pressure ventilation in pediatric patients admitted with status asthmaticus: a pilot study. Pediatr Crit Care Med. 2012;13:393–8.PubMedCrossRef
77.
Mayordomo-Colunga J, Medina A, Rey C, Concha A, Menéndez S, Arcos ML, Vivanco-Allende A. Non-invasive ventilation in pediatric status asthmaticus: a prospective observational study. Pediatr Pulmonol. 2011;46:949–55.PubMedCrossRef
78.
Baudin F, Buisson A, Vanel B, Massenavette B, Pouyau R, Javouhey E. Nasal high flow in management of children with status asthmaticus: a retrospective observational study. Ann Intensive Care. 2017;7:55.PubMedPubMedCentralCrossRef
79.
Pilar J, Modesto I Alapont V, Lopez-Fernandez YM, Lopez-Macias O, Garcia-Urabayen D, Amores-Hernandez I. High-flow nasal cannula therapy versus non-invasive ventilation in children with severe acute asthma exacerbation: an observational cohort study. Med Intensiva. 2017;41:418–24.PubMedCrossRef
80.
Pendergraft TB, Stanford RH, Beasley R, Stempel DA, Roberts C, McLaughlin T. Rates and characteristics of intensive care unit admissions and intubations among asthma-related hospitalizations. Ann Allergy Asthma Immunol. 2004;93:29–35.PubMedCrossRef
81.
Brenner B, Corbridge T, Kazzi A. Intubation and mechanical ventilation of the asthmatic patient in respiratory failure. J Emerg Med. 2009;37:S23–34.PubMedCrossRef
82.
Quintard H, l’Her E, Pottecher J, Adnet F, Constantin J-M, De Jong A, Diemunsch P, Fesseau R, Freynet A, Girault C, Guitton C, Hamonic Y, Maury E, Mekontso-Dessap A, Michel F, Nolent P, Perbet S, Prat G, Roquilly A, Tazarourte K, Terzi N, Thille AW, Alves M, Gayat E, Donetti L. Intubation and extubation of the ICU patient. Anaesth Crit Care Pain Med. 2017;36:327–41.PubMedCrossRef
83.
Ono Y, Kikuchi H, Hashimoto K, Sasaki T, Ishii J, Tase C, Shinohara K. Emergency endotracheal intubation-related adverse events in bronchial asthma exacerbation: can anesthesiologists attenuate the risk? J Anesth. 2015;29:678–85.PubMedCrossRef
84.
Newth CJL, Meert KL, Clark AE, Moler FW, Zuppa AF, Berg RA, Pollack MM, Sward KA, Berger JT, Wessel DL, Harrison RE, Reardon J, Carcillo JA, Shanley TP, Holubkov R, Dean JM, Doctor A, Nicholson CE, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Fatal and near-fatal asthma in children: the critical care perspective. J Pediatr. 2012;161:214–221.e3.PubMedPubMedCentralCrossRef
85.
Tuxen DV, Lane S. The effects of ventilatory pattern on hyperinflation, airway pressures, and circulation in mechanical ventilation of patients with severe air-flow obstruction. Am Rev Respir Dis. 1987;136:872–9.PubMedCrossRef
86.
Williams TJ, Tuxen DV, Scheinkestel CD, Czarny D, Bowes G. Risk factors for morbidity in mechanically ventilated patients with acute severe asthma. Am Rev Respir Dis. 1992;146:607–15.PubMedCrossRef
87.
Tuxen DV, Williams TJ, Scheinkestel CD, Czarny D, Bowes G. Use of a measurement of pulmonary hyperinflation to control the level of mechanical ventilation in patients with acute severe asthma. Am Rev Respir Dis. 1992;146:1136–42.PubMedCrossRef
88.
Leatherman JW, McArthur C, Shapiro RS. Effect of prolongation of expiratory time on dynamic hyperinflation in mechanically ventilated patients with severe asthma. Crit Care Med. 2004;32:1542–5.PubMedCrossRef
89.
Oddo M, Feihl F, Schaller M-D, Perret C. Management of mechanical ventilation in acute severe asthma: practical aspects. Intensive Care Med. 2006;32:501–10.PubMedCrossRef
90.
Leatherman JW, Ravenscraft SA. Low measured auto-positive end-expiratory pressure during mechanical ventilation of patients with severe asthma: hidden auto-positive end-expiratory pressure. Crit Care Med. 1996;24:541–6.PubMedCrossRef
91.
Kesler SM, Sprenkle MD, David WS, Leatherman JW. Severe weakness complicating status asthmaticus despite minimal duration of neuromuscular paralysis. Intensive Care Med. 2009;35:157–60.PubMedCrossRef
92.
Adnet F, Dhissi G, Borron SW, Galinski M, Rayeh F, Cupa M, Pourriat JL, Lapostolle F. Complication profiles of adult asthmatics requiring paralysis during mechanical ventilation. Intensive Care Med. 2001;27:1729–36.PubMedCrossRef
93.
94.
Golding CL, Miller JL, Gessouroun MR, Johnson PN. Ketamine continuous infusions in critically ill infants and children. Ann Pharmacother. 2016;50:234–41.PubMedCrossRef
95.
Achar MN, Achar KN. Efficacy of ketamine infusion in refractory asthma complicated by acute myocardial infarction. Anaesth Intensive Care. 1993;21:115–7.PubMedCrossRef
96.
Mondoñedo JR, McNeil JS, Amin SD, Herrmann J, Simon BA, Kaczka DW. Volatile anesthetics and the treatment of severe bronchospasm: a concept of targeted delivery. Drug Discov Today Dis Models. 2015;15:43–50.PubMedCrossRef
97.
Jat KR, Chawla D. Ketamine for management of acute exacerbations of asthma in children. Cochrane Database Syst Rev. 2012;11:293.
98.
Char DS, Ibsen LM, Ramamoorthy C, Bratton SL. Volatile anesthetic rescue therapy in children with acute asthma: innovative but costly or just costly? Pediatr Crit Care Med. 2013;14:343–50.PubMedCrossRef
99.
Turner DA, Heitz D, Cooper MK, Smith PB, Arnold JH, Bateman ST. Isoflurane for life-threatening bronchospasm: a 15-year single-center experience. Respir Care. 2012;57:1857–64.PubMedCrossRef
100.
Carter ER, Webb CR, Moffitt DR. Evaluation of heliox in children hospitalized with acute severe asthma. A randomized crossover trial. Chest. 1996;109:1256–61.PubMedCrossRef
101.
Kudukis TM, Manthous CA, Schmidt GA, Hall JB, Wylam ME. Inhaled helium-oxygen revisited: effect of inhaled helium-oxygen during the treatment of status asthmaticus in children. J Pediatr. 1997;130:217–24.PubMedCrossRef
102.
Henderson SO, Acharya P, Kilaghbian T, Perez J, Korn CS, Chan LS. Use of heliox-driven nebulizer therapy in the treatment of acute asthma. Ann Emerg Med. 1999;33:141–6.PubMedCrossRef
103.
Kass JE, Terregino CA. The effect of heliox in acute severe asthma: a randomized controlled trial. Chest. 1999;116:296–300.PubMedCrossRef
104.
L’Her E, Monchi M, Joly B, Marichy J, Lejay M, Dhainaut JF. Helium-oxygen breathing in the early emergency care of acute severe asthma: a randomized pilot study. Eur J Emerg Med. 2000;7:271–5.PubMedCrossRef
105.
Dorfman TA, Shipley ER, Burton JH, Jones P, Mette SA. Inhaled heliox does not benefit ED patients with moderate to severe asthma. Am J Emerg Med. 2000;18:495–7.PubMedCrossRef
106.
Rose JS, Panacek EA, Miller P. Prospective randomized trial of heliox-driven continuous nebulizers in the treatment of asthma in the emergency department. J Emerg Med. 2002;22:133–7.PubMedCrossRef
107.
Kress JP, Noth I, Gehlbach BK, Barman N, Pohlman AS, Miller A, Morgan S, Hall JB. The utility of albuterol nebulized with heliox during acute asthma exacerbations. Am J Respir Crit Care Med. 2002;165:1317–21.PubMedCrossRef
108.
Kim IK, Phrampus E, Venkataraman S, Pitetti R, Saville A, Corcoran T, Gracely E, Funt N, Thompson A. Helium/oxygen-driven albuterol nebulization in the treatment of children with moderate to severe asthma exacerbations: a randomized, controlled trial. Pediatrics. 2005;116:1127–33.PubMedCrossRef
109.
Lee DL, Hsu C-W, Lee H, Chang H-W, Huang Y-CT. Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation. Acad Emerg Med. 2005;12:820–7.PubMedCrossRef
110.
Xie L, Liu Y, Chen L, Hao F, Jin G, Zhao H. Inhaling beta(2)-agonist with heliox-driven in bronchial asthma. Chin Med J. 2003;116:1011–5.PubMed
111.
Rodrigo GJ, Castro-Rodriguez JA. Heliox-driven β2-agonists nebulization for children and adults with acute asthma: a systematic review with meta-analysis. Ann Allergy Asthma Immunol. 2014;112:29–34.PubMedCrossRef
112.
113.
Laube BL, Janssens HM, de Jongh FHC, Devadason SG, Dhand R, Diot P, Everard ML, Horvath I, Navalesi P, Voshaar T, Chrystyn H, European Respiratory Society, International Society for Aerosols in Medicine. What the pulmonary specialist should know about the new inhalation therapies. Eur Respir J. 2011;37:1308–31.PubMedCrossRef
114.
Caille V, Ehrmann S, Boissinot E, Perrotin D, Diot P, Dequin P-F. Influence of jet nebulization and oxygen delivery on the fraction of inspired oxygen: an experimental model. J Aerosol Med Pulm Drug Deliv. 2009;22:255–61.PubMedCrossRef
115.
Dolovich MB, Dhand R. Aerosol drug delivery: developments in device design and clinical use. Lancet. 2011;377:1032–45.PubMedCrossRef
116.
Réminiac F, Vecellio L, Heuzé-Vourc’h N, Petitcollin A, Respaud R, Cabrera M, Pennec DL, Diot P, Ehrmann S. Aerosol therapy in adults receiving high flow nasal cannula oxygen therapy. J Aerosol Med Pulm Drug Deliv. 2016;29:134–41.PubMedCrossRef
117.
Ari A, Fink JB, Dhand R. Inhalation therapy in patients receiving mechanical ventilation: an update. J Aerosol Med Pulm Drug Deliv. 2012;25:319–32.PubMedCrossRef
118.
Brenner K, Abrams DC, Agerstrand CL, Brodie D. Extracorporeal carbon dioxide removal for refractory status asthmaticus: experience in distinct exacerbation phenotypes. Perfusion. 2014;29:26–8.PubMedCrossRef
119.
Di Lascio G, Prifti E, Messai E, Peris A, Harmelin G, Xhaxho R, Fico A, Sani G, Bonacchi M. Extracorporeal membrane oxygenation support for life-threatening acute severe status asthmaticus. Perfusion. 2017;32:157–63.PubMedCrossRef
120.
Hebbar KB, Petrillo-Albarano T, Coto-Puckett W, Heard M, Rycus PT, Fortenberry JD. Experience with use of extracorporeal life support for severe refractory status asthmaticus in children. Crit Care. 2009;13:R29.PubMedPubMedCentralCrossRef
121.
Mikkelsen ME, Woo YJ, Sager JS, Fuchs BD, Christie JD. Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus. ASAIO J. 2009;55:47–52.PubMedPubMedCentralCrossRef
122.
Gatheral TL, Rushton A, Evans DJ, Mulvaney CA, Halcovitch NR, Whiteley G, Eccles FJ, Spencer S. Personalised asthma action plans for adults with asthma. Cochrane Database Syst Rev. 2017;4:CD011859.PubMed
123.
124.
125.
Moghaddas F, Smith C, Pilcher D, O’Hehir R, Hew M, Dabscheck E. Need for intensive care in patients admitted for asthma: red flags from the social history. Respirology. 2016;21:1251–4.PubMedCrossRef
126.
Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM, Cowan JO, Herbison GP, Silva PA, Poulton R. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med. 2003;349:1414–22.PubMedCrossRef
127.
Louie S, Morrissey BM, Kenyon NJ, Albertson TE, Avdalovic M. The critically ill asthmatic—from ICU to discharge. Clin Rev Allergy Immunol. 2012;43:30–44.PubMedCrossRef
128.
Cundiff KM, Gerard JM, Flood RG. Critical care interventions for asthmatic patients admitted from the emergency department to the pediatric intensive care unit. Pediatr Emerg Care. 2018;34:385–9.PubMedCrossRef
129.
130.
Hasegawa K, Cydulka RK, Sullivan AF, Langdorf MI, Nonas SA, Nowak RM, Wang NE, Camargo CA. Improved management of acute asthma among pregnant women presenting to the ED. Chest. 2015;147:406–14.PubMedCrossRef
131.
Murphy VE, Clifton VL, Gibson PG. Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes. Thorax. 2006;61:169–76.PubMedPubMedCentralCrossRef
132.
Rejnö G, Lundholm C, Gong T, Larsson K, Saltvedt S, Almqvist C. Asthma during pregnancy in a population-based study–pregnancy complications and adverse perinatal outcomes. PLoS ONE. 2014;9:e104755.PubMedPubMedCentralCrossRef
133.
Namazy JA, Murphy VE, Powell H, Gibson PG, Chambers C, Schatz M. Effects of asthma severity, exacerbations and oral corticosteroids on perinatal outcomes. Eur Respir J. 2013;41:1082–90.CrossRefPubMed
Metadata
Title
Management of severe asthma exacerbation: guidelines from the Société Française de Médecine d’Urgence, the Société de Réanimation de Langue Française and the French Group for Pediatric Intensive Care and Emergencies
Authors
Philippe Le Conte
Nicolas Terzi
Guillaume Mortamet
Fekri Abroug
Guillaume Carteaux
Céline Charasse
Anthony Chauvin
Xavier Combes
Stéphane Dauger
Alexandre Demoule
Thibaut Desmettre
Stephan Ehrmann
Bénédicte Gaillard-Le Roux
Valérie Hamel
Boris Jung
Sabrina Kepka
Erwan L’Her
Mikaël Martinez
Christophe Milési
Élise Morawiec
Mathieu Oberlin
Patrick Plaisance
Robin Pouyau
Chantal Raherison
Patrick Ray
Mathieu Schmidt
Arnaud W. Thille
Jennifer Truchot
Guillaume Valdenaire
Julien Vaux
Damien Viglino
Guillaume Voiriot
Bénédicte Vrignaud
Sandrine Jean
Eric Mariotte
Pierre-Géraud Claret
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Annals of Intensive Care / Issue 1/2019
Electronic ISSN: 2110-5820
DOI
https://doi.org/10.1186/s13613-019-0584-x

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