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Annals of Intensive Care
Published in: Annals of Intensive Care 1/2017

Open Access 01-12-2017 | Review

Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

Authors: Antoine Dewitte, Sébastien Lepreux, Julien Villeneuve, Claire Rigothier, Christian Combe, Alexandre Ouattara, Jean Ripoche

Published in: Annals of Intensive Care | Issue 1/2017

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Abstract

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum of their role in health and disease. Here, we propose a narrative review that first describes these new platelet attributes. We then examine their relevance to microcirculatory alterations in multi-organ dysfunction, a major sepsis complication. Rapid progresses that are made on the knowledge of novel platelet functions should improve the understanding of thrombocytopenia, a common condition and a predictor of adverse outcome in sepsis, and may provide potential avenues for management and therapy.
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Metadata
Title
Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?
Authors
Antoine Dewitte
Sébastien Lepreux
Julien Villeneuve
Claire Rigothier
Christian Combe
Alexandre Ouattara
Jean Ripoche
Publication date
01-12-2017
Publisher
Springer International Publishing
Published in
Annals of Intensive Care / Issue 1/2017
Electronic ISSN: 2110-5820
DOI
https://doi.org/10.1186/s13613-017-0337-7

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