Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 1/2013

01-02-2013 | Letter

Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients

Authors: Maik Sossdorf, Gordon P Otto, Janina Boettel, Johannes Winning, Wolfgang Lösche

Published in: Critical Care | Issue 1/2013

Login to get access

Abstract

Analyzing medical records of 979 patients with severe sepsis or septic shock provided some evidence that the use of low-dose aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) was associated with decreased hospital mortality. However, the benefit was abolished when aspirin and NSAIDs were given together.
Literature
1.
Eisen DP: Manifold beneficial effects of acetyl salicylic acid and non-steroidal anti-inflammatory drugs on sepsis. Intensive Care Med 2012, 38: 1249-1257. 10.1007/s00134-012-2570-8CrossRefPubMed
2.
Winning J, Neumann J, Kohl M, Claus RA, Reinhart K, Bauer M, Lösche W: Antiplatelet drugs and outcome in mixed admissions to an intensive care unit. Crit Care Med 2010, 38: 32-37. 10.1097/CCM.0b013e3181b4275cCrossRefPubMed
3.
Winning J, Reichel J, Eisenhut Y, Hamacher J, Kohl M, Deigner HP, Claus RA, Bauer M, Lösche W: Anti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanisms. Platelets 2009, 20: 50-57. 10.1080/09537100802503368CrossRefPubMed
4.
Sanchez MA, Thomas CB, O'Neal HR: Do aspirin and statins prevent severe sepsis? Curr Opin Infect Dis 2012, 25: 345-350. 10.1097/QCO.0b013e3283520ed7CrossRefPubMed
5.
Bernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson WJ, Wright PE, Christman BW, Dupont WD, Higgins SB, Swindell BB: The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med 1997, 336: 912-918. 10.1056/NEJM199703273361303CrossRefPubMed
Metadata
Title
Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients
Authors
Maik Sossdorf
Gordon P Otto
Janina Boettel
Johannes Winning
Wolfgang Lösche
Publication date
01-02-2013
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2013
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11886

Other articles of this Issue 1/2013

Critical Care 1/2013 Go to the issue

Research

Liver transplantation in the critically ill: a multicenter Canadian retrospective cohort study

Research

A French multicenter randomised trial comparing two dose-regimens of prothrombin complex concentrates in urgent anticoagulation reversal

Review

Clinical review: Practical approach to hyponatraemia and hypernatraemia in critically ill patients

Commentary

Protease-activated receptor-1: key player in the sepsis coagulation-inflammation crosstalk

Commentary

The brain after critical illness: effect of illness and aging on cognitive function

Letter

Topical nystatin prophylaxis: a likely viable measure for reducing impact of candidemia in neurosurgical patients with early tracheostomy intubation