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Intensive Care Medicine
Published in: Intensive Care Medicine 8/2010

01-08-2010 | Review

The endothelium: physiological functions and role in microcirculatory failure during severe sepsis

Authors: H. Ait-Oufella, E. Maury, S. Lehoux, B. Guidet, G. Offenstadt

Published in: Intensive Care Medicine | Issue 8/2010

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Abstract

The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological functions, including the control of vascular tone, the movement of cells and nutrients, the maintenance of blood fluidity and the growth of new vessels. During severe sepsis, the endothelium becomes proadhesive, procoagulant, antifibrinolytic and is characterized by alterations of vasomotor regulation. Most of these functions have been discovered using in vitro and animal models, but in vivo exploration of endothelium in patients remains difficult. New tools to analyze endothelial dysfunction at bedside have to be developed.
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Metadata
Title
The endothelium: physiological functions and role in microcirculatory failure during severe sepsis
Authors
H. Ait-Oufella
E. Maury
S. Lehoux
B. Guidet
G. Offenstadt
Publication date
01-08-2010
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 8/2010
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-010-1893-6

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