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Open Access 01-12-2019 | Cardiomyopathy | Original Article

Clinical evaluation of left ventricular function and morphology using an accelerated k-t sensitivity encoding method in cardiovascular magnetic resonance

Authors: Antonildes Nascimento Assuncao-Jr, Roberto Nery Dantas-Jr, Renata Margarida do Val, Priscilla Gianotto, Angela dos Santos Marin, Mark Golden, Marco Antonio Gutierrez, Jose Rodrigues Parga, Cesar Higa Nomura

Published in: Insights into Imaging | Issue 1/2019

Abstract

Objectives

To provide clinical validation of a recent 2D SENSE-based accelerated cardiovascular magnetic resonance (CMR) sequence (accelerated k-t SENSE), investigating whether this technique accurately quantifies left ventricle (LV) volumes, function, and mass as compared to 2D cine steady-state free precession (2D-SSFP).

Methods

Healthy volunteers (n = 16) and consecutive heart failure patients (n = 26) were scanned using a 1.5 T MRI system. Two LV short axis (SA) stacks were acquired: (1) accelerated k-t SENSE (5–6 breath-holds; temporal/spatial resolution: 37 ms/1.82 × 1.87 mm; acceleration factor = 4) and (2) standard 2D-SSFP (10–12 breath-holds; temporal/spatial resolution: 49 ms/1.67 × 1.87 mm, parallel imaging). Ascending aorta phase-contrast was performed on all volunteers as a reference to compare LV stroke volumes (LVSV) and validate the sequences. An image quality score for SA images was used, with lower scores indicating better quality (from 0 to 18).

Results

There was a high agreement between accelerated k-t SENSE and 2D-SSFP for LV measurements: bias (limits of agreement) of 2.4% (− 5.4% to 10.1%), 6.9 mL/m² (− 4.7 to 18.6 mL/m²), − 1.5 (− 8.3 to 5.2 mL/m²), and − 0.2 g/m² (− 11.9 to 12.3 g/m²) for LV ejection fraction, end-diastolic volume index, end-systolic volume index, and mass index, respectively. LVSV by accelerated k-t SENSE presented good agreement with aortic flow. Interobserver and intraobserver variabilities for all LV parameters were also high.

Conclusion

The accelerated k-t SENSE CMR sequence is clinically feasible and accurately quantifies LV volumes, function, and mass, with short acquisition time and good image quality.

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Title: Clinical evaluation of left ventricular function and morphology using an accelerated k-t sensitivity encoding method in cardiovascular magnetic resonance
Authors: Antonildes Nascimento Assuncao-Jr
Roberto Nery Dantas-Jr
Renata Margarida do Val
Priscilla Gianotto
Angela dos Santos Marin
Mark Golden
Marco Antonio Gutierrez
Jose Rodrigues Parga
Cesar Higa Nomura
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Keyword: Cardiomyopathy
Published in: Insights into Imaging / Issue 1/2019
Electronic ISSN: 1869-4101
DOI: https://doi.org/10.1186/s13244-019-0750-6

At a glance: The STEP trials

Springer Medicine

Clinical evaluation of left ventricular function and morphology using an accelerated k-t sensitivity encoding method in cardiovascular magnetic resonance

Abstract

Objectives

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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