Skip to main content
Top
Published in: Arthritis Research & Therapy 1/2021

01-12-2021 | Inflammatory Rheumatic Diseases | Research article

Accuracy, patient-perceived usability, and acceptance of two symptom checkers (Ada and Rheport) in rheumatology: interim results from a randomized controlled crossover trial

Authors: Johannes Knitza, Jacob Mohn, Christina Bergmann, Eleni Kampylafka, Melanie Hagen, Daniela Bohr, Harriet Morf, Elizabeth Araujo, Matthias Englbrecht, David Simon, Arnd Kleyer, Timo Meinderink, Wolfgang Vorbrüggen, Cay Benedikt von der Decken, Stefan Kleinert, Andreas Ramming, Jörg H. W. Distler, Nicolas Vuillerme, Achim Fricker, Peter Bartz-Bazzanella, Georg Schett, Axel J. Hueber, Martin Welcker

Published in: Arthritis Research & Therapy | Issue 1/2021

Login to get access

Abstract

Background

Timely diagnosis and treatment are essential in the effective management of inflammatory rheumatic diseases (IRDs). Symptom checkers (SCs) promise to accelerate diagnosis, reduce misdiagnoses, and guide patients more effectively through the health care system. Although SCs are increasingly used, there exists little supporting evidence.

Objective

To assess the diagnostic accuracy, patient-perceived usability, and acceptance of two SCs: (1) Ada and (2) Rheport.

Methods

Patients newly presenting to a German secondary rheumatology outpatient clinic were randomly assigned in a 1:1 ratio to complete Ada or Rheport and consecutively the respective other SCs in a prospective non-blinded controlled randomized crossover trial. The primary outcome was the accuracy of the SCs regarding the diagnosis of an IRD compared to the physicians’ diagnosis as the gold standard. The secondary outcomes were patient-perceived usability, acceptance, and time to complete the SC.

Results

In this interim analysis, the first 164 patients who completed the study were analyzed. 32.9% (54/164) of the study subjects were diagnosed with an IRD. Rheport showed a sensitivity of 53.7% and a specificity of 51.8% for IRDs. Ada’s top 1 (D1) and top 5 disease suggestions (D5) showed a sensitivity of 42.6% and 53.7% and a specificity of 63.6% and 54.5% concerning IRDs, respectively. The correct diagnosis of the IRD patients was within the Ada D1 and D5 suggestions in 16.7% (9/54) and 25.9% (14/54), respectively. The median System Usability Scale (SUS) score of Ada and Rheport was 75.0/100 and 77.5/100, respectively. The median completion time for both Ada and Rheport was 7.0 and 8.5 min, respectively. Sixty-four percent and 67.1% would recommend using Ada and Rheport to friends and other patients, respectively.

Conclusions

While SCs are well accepted among patients, their diagnostic accuracy is limited to date.

Trial registration

DRKS.de, DRKS00017642. Registered on 23 July 2019
Literature
1.
go back to reference Combe B, Landewe R, Daien CI, Hua C, Aletaha D, Álvaro-Gracia JM, Bakkers M, Brodin N, Burmester GR, Codreanu C, Conway R, Dougados M, Emery P, Ferraccioli G, Fonseca J, Raza K, Silva-Fernández L, Smolen JS, Skingle D, Szekanecz Z, Kvien TK, van der Helm-van Mil A, van Vollenhoven R. 2016 update of the EULAR recommendations for the management of early arthritis. Ann Rheum Dis. 2017;76(6):948–59. https://doi.org/10.1136/annrheumdis-2016-210602.CrossRefPubMed Combe B, Landewe R, Daien CI, Hua C, Aletaha D, Álvaro-Gracia JM, Bakkers M, Brodin N, Burmester GR, Codreanu C, Conway R, Dougados M, Emery P, Ferraccioli G, Fonseca J, Raza K, Silva-Fernández L, Smolen JS, Skingle D, Szekanecz Z, Kvien TK, van der Helm-van Mil A, van Vollenhoven R. 2016 update of the EULAR recommendations for the management of early arthritis. Ann Rheum Dis. 2017;76(6):948–59. https://​doi.​org/​10.​1136/​annrheumdis-2016-210602.CrossRefPubMed
2.
go back to reference Quinn MA, Emery P. Window of opportunity in early rheumatoid arthritis: possibility of altering the disease process with early intervention. Clin Exp Rheumatol. 2003;21(0392-856X (Print)):154–7. Quinn MA, Emery P. Window of opportunity in early rheumatoid arthritis: possibility of altering the disease process with early intervention. Clin Exp Rheumatol. 2003;21(0392-856X (Print)):154–7.
3.
go back to reference Villeneuve E, Nam JL, Bell MJ, Deighton CM, Felson DT, Hazes JM, IB MI, Silman AJ, Solomon DH, Thompson AE, White PHP, et al. A systematic literature review of strategies promoting early referral and reducing delays in the diagnosis and management of inflammatory arthritis. Ann Rheum Dis. 2012;72(1468–2060 (Electronic)):13–22.PubMed Villeneuve E, Nam JL, Bell MJ, Deighton CM, Felson DT, Hazes JM, IB MI, Silman AJ, Solomon DH, Thompson AE, White PHP, et al. A systematic literature review of strategies promoting early referral and reducing delays in the diagnosis and management of inflammatory arthritis. Ann Rheum Dis. 2012;72(1468–2060 (Electronic)):13–22.PubMed
4.
go back to reference Benesova K, Lorenz HM, Lion V, Voigt A, Krause A, Sander O, Schneider M, Feuchtenberger M, Nigg A, Leipe J, Briem S, Tiessen E, Haas F, Rihl M, Meyer-Olson D, Baraliakos X, Braun J, Schwarting A, Dreher M, Witte T, Assmann G, Hoeper K, Schmidt RE, Bartz-Bazzanella P, Gaubitz M, Specker C. Früh- und Screeningsprechstunden: Ein notwendiger Weg zur besseren Frühversorgung in der internistischen Rheumatologie? Z Rheumatol. 2019;78(8):722–42. https://doi.org/10.1007/s00393-019-0683-y.CrossRefPubMed Benesova K, Lorenz HM, Lion V, Voigt A, Krause A, Sander O, Schneider M, Feuchtenberger M, Nigg A, Leipe J, Briem S, Tiessen E, Haas F, Rihl M, Meyer-Olson D, Baraliakos X, Braun J, Schwarting A, Dreher M, Witte T, Assmann G, Hoeper K, Schmidt RE, Bartz-Bazzanella P, Gaubitz M, Specker C. Früh- und Screeningsprechstunden: Ein notwendiger Weg zur besseren Frühversorgung in der internistischen Rheumatologie? Z Rheumatol. 2019;78(8):722–42. https://​doi.​org/​10.​1007/​s00393-019-0683-y.CrossRefPubMed
5.
go back to reference Raza K, Stack R, Kumar K, Filer A, Detert J, Bastian H, Burmester GR, Sidiropoulos P, Kteniadaki E, Repa A, Saxne T, Turesson C, Mann H, Vencovsky J, Catrina A, Chatzidionysiou A, Hensvold A, Rantapää-Dahlqvist S, Binder A, Machold K, Kwiakowska B, Ciurea A, Tamborrini G, Kyburz D, Buckley CD. Delays in assessment of patients with rheumatoid arthritis: variations across Europe. Ann Rheum Dis. 2011;70(10):1822–5. https://doi.org/10.1136/ard.2011.151902.CrossRefPubMed Raza K, Stack R, Kumar K, Filer A, Detert J, Bastian H, Burmester GR, Sidiropoulos P, Kteniadaki E, Repa A, Saxne T, Turesson C, Mann H, Vencovsky J, Catrina A, Chatzidionysiou A, Hensvold A, Rantapää-Dahlqvist S, Binder A, Machold K, Kwiakowska B, Ciurea A, Tamborrini G, Kyburz D, Buckley CD. Delays in assessment of patients with rheumatoid arthritis: variations across Europe. Ann Rheum Dis. 2011;70(10):1822–5. https://​doi.​org/​10.​1136/​ard.​2011.​151902.CrossRefPubMed
7.
go back to reference Knitza J, Simon D, Lambrecht A, Raab C, Tascilar K, Hagen M, Kleyer A, Bayat S, Derungs A, Amft O, et al. Mobile health in rheumatology: a patient survey study exploring usage, preferences, barriers and eHealth literacy. JMIR mHealth uHealth. 2020;8(8):e19661. Knitza J, Simon D, Lambrecht A, Raab C, Tascilar K, Hagen M, Kleyer A, Bayat S, Derungs A, Amft O, et al. Mobile health in rheumatology: a patient survey study exploring usage, preferences, barriers and eHealth literacy. JMIR mHealth uHealth. 2020;8(8):e19661.
9.
go back to reference Najm A, Nikiphorou E, Kostine M, Richez C, Pauling JD, Finckh A, Ritschl V, Prior Y, Balážová P, Stones S, Szekanecz Z, Iagnocco A, Ramiro S, Sivera F, Dougados M, Carmona L, Burmester G, Wiek D, Gossec L, Berenbaum F. EULAR points to consider for the development, evaluation and implementation of mobile health applications aiding self-management in people living with rheumatic and musculoskeletal diseases. RMD Open. 2019;5(2):e001014. https://doi.org/10.1136/rmdopen-2019-001014.CrossRefPubMedPubMedCentral Najm A, Nikiphorou E, Kostine M, Richez C, Pauling JD, Finckh A, Ritschl V, Prior Y, Balážová P, Stones S, Szekanecz Z, Iagnocco A, Ramiro S, Sivera F, Dougados M, Carmona L, Burmester G, Wiek D, Gossec L, Berenbaum F. EULAR points to consider for the development, evaluation and implementation of mobile health applications aiding self-management in people living with rheumatic and musculoskeletal diseases. RMD Open. 2019;5(2):e001014. https://​doi.​org/​10.​1136/​rmdopen-2019-001014.CrossRefPubMedPubMedCentral
10.
go back to reference Brooke J. SUS - a quick and dirty usability scale. In: Jordan PW, Thomas B, Weerdmeester BA, McClelland AL, editors. Usability evaluation in industry, vol. 194. London: Taylor and Francis; 1996. p. 189–194. Brooke J. SUS - a quick and dirty usability scale. In: Jordan PW, Thomas B, Weerdmeester BA, McClelland AL, editors. Usability evaluation in industry, vol. 194. London: Taylor and Francis; 1996. p. 189–194.
11.
go back to reference Feuchtenberger M, Nigg AP, Kraus MR, Schafer A. Rate of proven rheumatic diseases in a large collective of referrals to an outpatient rheumatology clinic under routine conditions. Clin Med Insights Arthritis Musculosskelet Diord. 2016;9(1179–5441 (Print)):181–7. Feuchtenberger M, Nigg AP, Kraus MR, Schafer A. Rate of proven rheumatic diseases in a large collective of referrals to an outpatient rheumatology clinic under routine conditions. Clin Med Insights Arthritis Musculosskelet Diord. 2016;9(1179–5441 (Print)):181–7.
12.
go back to reference Semigran HL, Linder JA, Gidengil C, Mehrotra A. Evaluation of symptom checkers for self diagnosis and triage: audit study. BMJ (Clinical research ed). 2015;351:h3480. Semigran HL, Linder JA, Gidengil C, Mehrotra A. Evaluation of symptom checkers for self diagnosis and triage: audit study. BMJ (Clinical research ed). 2015;351:h3480.
14.
go back to reference Sutton RT, Pincock D, Baumgart DC, Sadowski DC, Fedorak RN, Kroeker KI. An overview of clinical decision support systems: benefits, risks, and strategies for success. NPJ Digit Med. 2020;3(1):17.CrossRef Sutton RT, Pincock D, Baumgart DC, Sadowski DC, Fedorak RN, Kroeker KI. An overview of clinical decision support systems: benefits, risks, and strategies for success. NPJ Digit Med. 2020;3(1):17.CrossRef
19.
20.
go back to reference Gilbert S, Upadhyay S, Novorol C, Wicks P. The quality of condition suggestions and urgency advice provided by the Ada symptom assessment app assessed with independently generated vignettes optimized for Australia. medRxiv. 2020:2020.2006.2016.20132845. Gilbert S, Upadhyay S, Novorol C, Wicks P. The quality of condition suggestions and urgency advice provided by the Ada symptom assessment app assessed with independently generated vignettes optimized for Australia. medRxiv. 2020:2020.2006.2016.20132845.
22.
23.
go back to reference Ehrenstein B, Pongratz G, Fleck M, Hartung W. The ability of rheumatologists blinded to prior workup to diagnose rheumatoid arthritis only by clinical assessment: a cross-sectional study. Rheumatology (Oxford). 2018;57(1462–0332 (Electronic)):1592–601.CrossRef Ehrenstein B, Pongratz G, Fleck M, Hartung W. The ability of rheumatologists blinded to prior workup to diagnose rheumatoid arthritis only by clinical assessment: a cross-sectional study. Rheumatology (Oxford). 2018;57(1462–0332 (Electronic)):1592–601.CrossRef
Metadata
Title
Accuracy, patient-perceived usability, and acceptance of two symptom checkers (Ada and Rheport) in rheumatology: interim results from a randomized controlled crossover trial
Authors
Johannes Knitza
Jacob Mohn
Christina Bergmann
Eleni Kampylafka
Melanie Hagen
Daniela Bohr
Harriet Morf
Elizabeth Araujo
Matthias Englbrecht
David Simon
Arnd Kleyer
Timo Meinderink
Wolfgang Vorbrüggen
Cay Benedikt von der Decken
Stefan Kleinert
Andreas Ramming
Jörg H. W. Distler
Nicolas Vuillerme
Achim Fricker
Peter Bartz-Bazzanella
Georg Schett
Axel J. Hueber
Martin Welcker
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2021
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/s13075-021-02498-8

Other articles of this Issue 1/2021

Arthritis Research & Therapy 1/2021 Go to the issue