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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2017

Open Access 01-12-2017 | Review

Emerging technologies in autoantibody testing for rheumatic diseases

Authors: Nancy J. Olsen, May Y. Choi, Marvin J. Fritzler

Published in: Arthritis Research & Therapy | Issue 1/2017

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Abstract

Testing for the presence of antinuclear antibodies (ANAs) is a key step in the diagnosis of systemic lupus erythematosus (SLE) and other systemic autoimmune rheumatic diseases (SARD). The standard slide-based indirect immunofluorescence (IIF) test is widely used, but is limited by a relative lack of specificity for SLE and not all SARD-ANAs are detected. Alternative immunoassays that might offer enhanced diagnostic and prognostic information have evolved, and some of these have entered clinical practice. This review summarizes the current state of ANA testing and multiplex techniques for detecting other autoantibodies, the possibility of point-of-care testing, and approaches for applications in early disease stages.
Literature
1.
Maas K, Chan S, Parker J, Slater A, Moore J, Olsen N, Aune TM. Cutting edge: molecular portrait of human autoimmune disease. J Immunol. 2002;169(1):5–9.PubMedCrossRef
2.
Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol. 1997;84(3):223–43.PubMedCrossRef
3.
Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev. 2003;2(3):119–25.PubMedCrossRef
4.
Mahler M, Meroni PL, Bossuyt X, Fritzler MJ. Current concepts and future directions for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. J Immunol Res. 2014;2014:315179.PubMedPubMedCentral
5.
Valenzuela A, Chung L, Casciola-Rosen L, Fiorentino D. Identification of clinical features and autoantibodies associated with calcinosis in dermatomyositis. JAMA Dermatol. 2014;150(7):724–9.PubMedPubMedCentralCrossRef
6.
Choi MY, Barber MR, Barber CE, Clarke AE, Fritzler MJ. Preventing the development of SLE: identifying risk factors and proposing pathways for clinical care. Lupus. 2016;25(8):838–49.PubMedCrossRef
7.
Olsen NJ, McAloose C, Carter J, Han BK, Raman I, Li QZ, Liao D. Clinical and immunologic profiles in incomplete lupus erythematosus and improvement with hydroxychloroquine treatment. Autoimmune Dis. 2016;2016:8791629.PubMedPubMedCentral
8.
Fritzler MJ. Choosing wisely: review and commentary on anti-nuclear antibody (ANA) testing. Autoimmun Rev. 2016;15(3):272–80.PubMedCrossRef
9.
Hu SL, Wang D, Gou WJ, Lei QF, Ma TA, Cheng JZ. Diagnostic value of phospholipase A2 receptor in idiopathic membranous nephropathy: a systematic review and meta-analysis. J Nephrol. 2014;27(2):111–6.PubMedCrossRef
10.
Dougherty ER. Biomarker development: prudence, risk, and reproducibility. Bioessays. 2012;34(4):277–9.PubMedCrossRef
11.
Kavanaugh AF, Solomon DH. American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines. Guidelines for immunologic laboratory testing in the rheumatic diseases: anti-DNA antibody tests. Arthritis Rheum. 2002;47(5):546–55.PubMedCrossRef
12.
Conrad K, Andrade LE, Chan EK, Mahler M, Meroni PL, Pruijn GJ, Steiner G, Shoenfeld Y. From autoantibody research to standardized diagnostic assays in the management of human diseases—report of the 12th Dresden Symposium on Autoantibodies. Lupus. 2016;25(8):787–96.PubMedCrossRef
13.
Guillemin F. How to assess musculoskeletal conditions. Assessment of disease activity. Best Pract Res Clin Rheumatol. 2003;17(3):415–26.PubMedCrossRef
14.
Yazdany J, Schmajuk G, Robbins M, Daikh D, Beall A, Yelin E, Barton J, Carlson A, Margaretten M, Zell J, et al. Choosing wisely: the American College of Rheumatology's top 5 list of things physicians and patients should question. Arthritis Care Res (Hoboken). 2013;65(3):329–39.CrossRef
15.
Kleinnijenhuis J, van der Molen RG, Franssen PM, Berden JH, van der Meer JW, Jacobs JF. Anti-ribosomal P antibodies as a single serological marker in SLE: lupus in disguise. Scand J Rheumatol. 2013;42(2):165–6.PubMedCrossRef
16.
17.
Chan EK, Damoiseaux J, De Melo CW, Carballo OG, Conrad K, Francescantonio PL, Fritzler MJ, Garcia-De La Torre I, Herold M, Mimori T, et al. Report on the second International Consensus on ANA Pattern (ICAP) workshop in Dresden 2015. Lupus. 2016;25(8):797–804.PubMedCrossRef
18.
Lakos G, Gonzalez M, Flaherty D, Bentow C, Ibarra C, Stimson D, Nacario L, Hiemann R, Dervieux T. Detection of anti-dsDNA antibodies by computer-aided automated immunofluorescence analysis. J Immunol Methods. 2016;433:17–22.PubMedCrossRef
19.
Nossent H, Rekvig OP. Antinuclear antibody screening in this new millennium: farewell to the microscope? Scand J Rheumatol. 2001;30(3):123–6. discussion 127–8.PubMedCrossRef
20.
Fritzler MJ. The antinuclear antibody test: last or lasting gasp? Arthritis Rheum. 2011;63(1):19–22.PubMedCrossRef
21.
Meroni P, Schur P. ANA screening: an old test with new recommendations. Ann Rheum Dis. 2010;69(8):1420-2.
22.
Kavanaugh A, Tomar R, Reveille J, Solomon DH, Homburger HA. Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of Pathologists. Arch Pathol Lab Med. 2000;124(1):71–81.PubMed
23.
Mahler M, Ngo JT, Schulte-Pelkum J, Luettich T, Fritzler MJ. Limited reliability of the indirect immunofluorescence technique for the detection of anti-Rib-P antibodies. Arthritis Res Ther. 2008;10(6):R131.PubMedPubMedCentralCrossRef
24.
Damoiseaux J, von Mühlen CA, Garcia-De La Torre I, Carballo OG, de Melo Cruvinel W, Francescantonio PL, Fritzler MJ, Herold M, Mimori T, Satoh M, et al. International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results. Auto Immun Highlights. 2016;7(1):1.PubMedPubMedCentralCrossRef
25.
Keech CL, McCluskey J, Gordon TP. Transfection and overexpression of the human 60-kDa Ro/SS-A autoantigen in HEp-2 cells. Clin Immunol Immunopathol. 1994;73(1):146–51.PubMedCrossRef
26.
Fritzler MJ, Hanson C, Miller J, Eystathioy T. Specificity of autoantibodies to SS-A/Ro on a transfected and overexpressed human 60 kDa Ro autoantigen substrate. J Clin Lab Anal. 2002;16(2):103–8.PubMedCrossRef
27.
Malyavantham K, Suresh L. Analysis of DFS70 pattern and impact on ANA screening using a novel HEp-2 ELITE/DFS70 knockout substrate. Auto Immun Highlights. 2017;8(1):3.PubMedPubMedCentralCrossRef
28.
Sinclair D, Saas M, Williams D, Hart M, Goswami R. Can an ELISA replace immunofluorescence for the detection of anti-nuclear antibodies? The routine use of anti-nuclear antibody screening ELISAs. Clin Lab. 2007;53(3–4):183–91.PubMed
29.
López-Hoyos M, Rodríguez-Valverde V, Martinez-Taboada V. Performance of antinuclear antibody connective tissue disease screen. Ann N Y Acad Sci. 2007;1109:322–9.PubMedCrossRef
30.
Fenger M, Wiik A, Høier-Madsen M, Lykkegaard JJ, Rozenfeld T, Hansen MS, Samsoe BD, Jacobsen S. Detection of antinuclear antibodies by solid-phase immunoassays and immunofluorescence analysis. Clin Chem. 2004;50(11):2141–7.PubMedCrossRef
31.
Copple SS, Sawitzke AD, Wilson AM, Tebo AE, Hill HR. Enzyme-linked immunosorbent assay screening then indirect immunofluorescence confirmation of antinuclear antibodies: a statistical analysis. Am J Clin Pathol. 2011;135(5):678–84.PubMedCrossRef
32.
Almeida González D, Cabrera de León A, Rodríguez Pérez MC, Brito Díaz B, González Hernández A, García García D, Vázquez Moncholi C, Aguirre Jaime A. Efficiency of different strategies to detect autoantibodies to extractable nuclear antigens. J Immunol Methods. 2010;360(1–2):89–95.PubMedCrossRef
33.
Lee SA, Kahng J, Kim Y, Park YJ, Han K, Kwok SK, Park SH, Oh EJ. Comparative study of immunofluorescent antinuclear antibody test and line immunoassay detecting 15 specific autoantibodies in patients with systemic rheumatic disease. J Clin Lab Anal. 2012;26(4):307–14.PubMedCrossRef
34.
Fritzler MJ, Fritzler ML. Microbead-based technologies in diagnostic autoantibody detection. Expert Opin Med Diagn. 2009;3(1):81–9.PubMedCrossRef
35.
Mahler M, Bentow C, Serra J, Fritzler MJ. Detection of autoantibodies using chemiluminescence technologies. Immunopharmacol Immunotoxicol. 2016;38(1):14–20.PubMedCrossRef
36.
Ghillani P, Rouquette AM, Desgruelles C, Hauguel N, Le Pendeven C, Piette JC, Musset L. Evaluation of the LIAISON ANA screen assay for antinuclear antibody testing in autoimmune diseases. Ann N Y Acad Sci. 2007;1109:407–13.PubMedCrossRef
37.
Zafrir Y, Gilburd B, Carrasco MG, Kivity S, Sánchez-Castañón M, López-Hoyos M, Mandel M, Szmyrka M, Shoenfeld Y, Agmon-Levin N. Evaluation of an automated chemiluminescent immunoassay kit for antinuclear antibodies in autoimmune diseases. Immunol Res. 2013;56(2–3):451–6.PubMedCrossRef
38.
Xu X, Wu WY, Tu WZ, Chu HY, Zhu XX, Liang MR, Xue Y, Wang JC, Zou HJ. Increased expression of S100A8 and S100A9 in patients with diffuse cutaneous systemic sclerosis. A correlation with organ involvement and immunological abnormalities. Clin Rheumatol. 2013;32(10):1501–10.PubMedCrossRef
39.
Shovman O, Gilburd B, Barzilai O, Shinar E, Larida B, Zandman-Goddard G, Binder SR, Shoenfeld Y. Evaluation of the BioPlex 2200 ANA screen: analysis of 510 healthy subjects: incidence of natural/predictive autoantibodies. Ann N Y Acad Sci. 2005;1050:380–8.PubMedCrossRef
40.
Shovman O, Gilburd B, Zandman-Goddard G, Yehiely A, Langevitz P, Shoenfeld Y. Multiplexed AtheNA multi-lyte immunoassay for ANA screening in autoimmune diseases. Autoimmunity. 2005;38(1):105–9.PubMedCrossRef
41.
Avaniss-Aghajani E, Berzon S, Sarkissian A. Clinical value of multiplexed bead-based immunoassays for detection of autoantibodies to nuclear antigens. Clin Vaccine Immunol. 2007;14(5):505–9.PubMedPubMedCentralCrossRef
42.
Hanly JG, Su L, Farewell V, Fritzler MJ. Comparison between multiplex assays for autoantibody detection in systemic lupus erythematosus. J Immunol Methods. 2010;358(1–2):75–80.PubMedCrossRef
43.
Nifli AP, Notas G, Mamoulaki M, Niniraki M, Ampartzaki V, Theodoropoulos PA, Kopnitsky MJ, Castanas E. Comparison of a multiplex, bead-based fluorescent assay and immunofluorescence methods for the detection of ANA and ANCA autoantibodies in human serum. J Immunol Methods. 2006;311(1–2):189–97.PubMedCrossRef
44.
Mahler M, Meroni PL, Andrade LE, Khamashta M, Bizzaro N, Casiano CA, Fritzler MJ. Towards a better understanding of the clinical association of anti-DFS70 autoantibodies. Autoimmun Rev. 2016;15(2):198–201.PubMedCrossRef
45.
Seelig CA, Bauer O, Seelig HP. Autoantibodies against DFS70/LEDGF exclusion markers for systemic autoimmune rheumatic diseases (SARD). Clin Lab. 2016;62(4):499–517.PubMed
46.
Choi MY, Clarke AE, St Pierre Y, Hanly JG, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Wallace DJ, et al. The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients. Lupus. 2017. doi:10.​1177/​0961203317692437​.
47.
Ochs RL, Mahler M, Basu A, Rios-Colon L, Sanchez TW, Andrade LE, Fritzler MJ, Casiano CA. The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding. Clin Exp Med. 2016;16(3):273–93.PubMedCrossRef
48.
Yaniv G, Twig G, Shor DB, Furer A, Sherer Y, Mozes O, Komisar O, Slonimsky E, Klang E, Lotan E, et al. A volcanic explosion of autoantibodies in systemic lupus erythematosus: a diversity of 180 different antibodies found in SLE patients. Autoimmun Rev. 2015;14(1):75–9.PubMedCrossRef
49.
Robinson WH, DiGennaro C, Hueber W, Haab BB, Kamachi M, Dean EJ, Fournel S, Fong D, Genovese MC, de Vegvar HE, et al. Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat Med. 2002;8(3):295–301.PubMedCrossRef
50.
Price JV, Haddon DJ, Kemmer D, Delepine G, Mandelbaum G, Jarrell JA, Gupta R, Balboni I, Chakravarty EF, Sokolove J, et al. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J Clin Invest. 2013;123(12):5135–45.PubMedPubMedCentralCrossRef
51.
Zhu H, Luo H, Yan M, Zuo X, Li QZ. Autoantigen microarray for high-throughput autoantibody profiling in systemic lupus erythematosus. Genomics Proteomics Bioinformatics. 2015;13(4):210–8.PubMedPubMedCentralCrossRef
52.
Li Q, Zhou J, Wandstrat A, Carr-Johnson F, Branch V, Karp D, Mohan C, Wakeland E, Olsen N. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes. Clin Exp Immunol. 2007;147(1):60–70.PubMedPubMedCentral
53.
Li Q, Zhou J, Lian Y, Zhang B, Branch V, Carr-Johnson F, Karp D, Mohan C, Wakeland E, Olsen N. Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes. Clin Exp Immunol. 2010;159(3):281–91.PubMedPubMedCentralCrossRef
54.
Fattal I, Shental N, Mevorach D, Anaya JM, Livneh A, Langevitz P, Zandman-Goddard G, Pauzner R, Lerner M, Blank M, et al. An antibody profile of systemic lupus erythematosus detected by antigen microarray. Immunology. 2010;130(3):337–43.PubMedPubMedCentralCrossRef
55.
Silverman G, Srikrishnan R, Germar K, Goodyear C, Andrews K, Ginzler E, Tsao B. Genetic imprinting of autoantibody repertoires in systemic lupus erythematosus patients. Clin Exp Immunol. 2008;153(1):102–16.PubMedPubMedCentralCrossRef
56.
Hu C, Huang W, Chen H, Song G, Li P, Shan Q, Zhang X, Zhang F, Zhu H, Wu L, et al. Autoantibody profiling on human proteome microarray for biomarker discovery in cerebrospinal fluid and sera of neuropsychiatric lupus. PLoS One. 2015;10(5):e0126643.PubMedPubMedCentralCrossRef
57.
Haddon DJ, Diep VK, Price JV, Limb C, Utz PJ, Balboni I. Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus. Arthritis Res Ther. 2015;17:162.PubMedPubMedCentralCrossRef
58.
Hutcheson J, Ye Y, Han J, Arriens C, Saxena R, Li QZ, Mohan C, Wu T. Resistin as a potential marker of renal disease in lupus nephritis. Clin Exp Immunol. 2015;179(3):435–43.PubMedPubMedCentralCrossRef
59.
60.
61.
Quan J, Lakhanpal A, Reddy MM, Zaman S, Li QZ, German DC, Olsen NJ, Kodadek T, Karp DR. Discovery of biomarkers for systemic lupus erythematosus using a library of synthetic autoantigen surrogates. J Immunol Methods. 2013;402(1–2):23–34.PubMedPubMedCentral
62.
Cohen IR, Putterman C, Jordan N, Jakobi K, Sorek R, Blumenstein Y, Batty S. SLE-key Rule-out serologic test for SLE using the immunarray ICHIP. Annals Rheum Dis. 2015;74(Suppl 2)
63.
Putterman C, Wu A, Reiner-Benaim A, Batty DS, Sanz I, Oates J, Jakobi K, Petri M, Safer P, Gerwien R, et al. SLE-key(®) rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: developing the ImmunArray iCHIP(®). J Immunol Methods. 2016;429:1–6.PubMedCrossRef
64.
Wang L, Mohan C, Li QZ. Arraying autoantibodies in SLE—lessons learned. Curr Mol Med. 2015;15(5):456–61.PubMedCrossRef
65.
Zhang B, Jarrell JA, Price JV, Tabakman SM, Li Y, Gong M, Hong G, Feng J, Utz PJ, Dai H. An integrated peptide-antigen microarray on plasmonic gold films for sensitive human antibody profiling. PLoS One. 2013;8(7):e71043.PubMedPubMedCentralCrossRef
66.
Kattah MG, Alemi GR, Thibault DL, Balboni I, Utz PJ. A new two-color Fab labeling method for autoantigen protein microarrays. Nat Methods. 2006;3(9):745–51.PubMedCrossRef
67.
Budde P, Zucht HD, Vordenbäumen S, Goehler H, Fischer-Betz R, Gamer M, Marquart K, Rengers P, Richter J, Lueking A, et al. Multiparametric detection of autoantibodies in systemic lupus erythematosus. Lupus. 2016;25(8):812–22.PubMedCrossRef
68.
Pisetsky DS. Anti-DNA antibodies—quintessential biomarkers of SLE. Nat Rev Rheumatol. 2016;12(2):102–10.PubMedCrossRef
69.
Arbuckle M, McClain M, Rubertone M, Scofield R, Dennis G, James J, Harley J. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med. 2003;349(16):1526–33.PubMedCrossRef
70.
Olsen NJ, Karp DR. Autoantibodies and SLE: the threshold for disease. Nat Rev Rheumatol. 2014;10(3):181–6.PubMedCrossRef
71.
Aberle T, Bourn RL, Munroe ME, Chen H, Roberts VC, Guthridge JM, Bean K, Robertson JM, Sivils KL, Rasmussen A, et al. Clinical and serological features distinguish patients with incomplete lupus classification from systemic lupus erythematosus patients and controls. Arthritis Care Res (Hoboken). 2017. doi:10.​1002/​acr.​23201.
72.
Olsen NJ, Li QZ, Quan J, Wang L, Mutwally A, Karp DR. Autoantibody profiling to follow evolution of lupus syndromes. Arthritis Res Ther. 2012;14(4):R174.PubMedPubMedCentralCrossRef
73.
Lu R, Munroe ME, Guthridge JM, Bean KM, Fife DA, Chen H, Slight-Webb SR, Keith MP, Harley JB, James JA. Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies. J Autoimmun. 2016;74:182–93.PubMedCrossRef
74.
Fritzler MJ. Perspectives on the imperatives, opportunities and challenges for point of care diagnostics in systemiclupus erythematosus. Int J Clin Rheumatol. 2015;9:449–56.CrossRef
75.
Janssen NM, Karnad DR, Guntupalli KK. Rheumatologic diseases in the intensive care unit: epidemiology, clinical approach, management, and outcome. Crit Care Clin. 2002;18(4):729–48.PubMedCrossRef
76.
Sharma M, Leirisalo-Repo M. Arthritis patient as an emergency case at a university hospital. Scand J Rheumatol. 1997;26(1):30–6.PubMedCrossRef
77.
Panopalis P, Gillis JZ, Yazdany J, Trupin L, Hersh A, Julian L, Criswell LA, Katz P, Yelin E. Frequent use of the emergency department among persons with systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2010;62(3):401–8.CrossRef
78.
Hanly JG, Thompson K, Skedgel C. Utilization of ambulatory physician encounters, emergency room visits, and hospitalizations by systemic lupus erythematosus patients: a 13-year population health study. Arthritis Care Res (Hoboken). 2016;68(8):1128–34.CrossRef
79.
Offermann N, Conrad K, Fritzler MJ, Fooke AM. Development and validation of a lateral flow assay (LFA) for the determination of IgG-antibodies to Pr3 (cANCA) and MPO (pANCA). J Immunol Methods. 2014;403(1–2):1–6.PubMed
80.
81.
Konstantinov KN, Tzamaloukas A, Rubin RL. Detection of autoantibodies in a point-of-care rheumatology setting. Auto Immun Highlights. 2013;4(2):55–61.PubMedPubMedCentralCrossRef
82.
Rubin RL, Wall D, Konstantinov KN. Electrochemical biosensor for quantitation of anti-DNA autoantibodies in human serum. Biosens Bioelectron. 2014;51:177–83.PubMedCrossRef
83.
Poulsen NN, Pedersen ME, Østergaard J, Petersen NJ, Nielsen CT, Heegaard NH, Jensen H. Flow-induced dispersion analysis for probing anti-dsDNA antibody binding heterogeneity in systemic lupus erythematosus patients: toward a new approach for diagnosis and patient stratification. Anal Chem. 2016;88(18):9056–61.PubMedCrossRef
84.
Hayashi N, Kawamoto T, Mukai M, Morinobu A, Koshiba M, Kondo S, Maekawa S, Kumagai S. Detection of antinuclear antibodies by use of an enzyme immunoassay with nuclear HEp-2 cell extract and recombinant antigens: comparison with immunofluorescence assay in 307 patients. Clin Chem. 2001;47(9):1649–59.PubMed
85.
Grossmann K, Roggenbuck D, Schröder C, Conrad K, Schierack P, Sack U. Multiplex assessment of non-organ-specific autoantibodies with a novel microbead-based immunoassay. Cytometry A. 2011;79(2):118–25.PubMedCrossRef
86.
Smith J, Onley D, Garey C, Crowther S, Cahir N, Johanson A, Painter S, Harradence G, Davis R, Swarbrick P. Determination of ANA specificity using the UltraPlex platform. Ann N Y Acad Sci. 2005;1050:286–94.PubMedCrossRef
Metadata
Title
Emerging technologies in autoantibody testing for rheumatic diseases
Authors
Nancy J. Olsen
May Y. Choi
Marvin J. Fritzler
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2017
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/s13075-017-1380-3

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