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Open Access 01-12-2016 | Original Article

International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results

Authors: Jan Damoiseaux, Carlos A. von Mühlen, Ignacio Garcia-De La Torre, Orlando Gabriel Carballo, Wilson de Melo Cruvinel, Paulo Luiz Carvalho Francescantonio, Marvin J. Fritzler, Manfred Herold, Tsuneyo Mimori, Minoru Satoh, Luis E. C. Andrade, Edward K. L. Chan, Karsten Conrad

Published in: Autoimmunity Highlights | Issue 1/2016

Abstract

The International Consensus on ANA Patterns (ICAP) was initiated as a workshop aiming to thoroughly discuss and achieve consensus regarding the morphological patterns observed in the indirect immunofluorescence assay on HEp-2 cells. One of the topics discussed at the second ICAP workshop, and addressed in this paper, was the harmonization of reporting ANA test results. This discussion centered on the issue if cytoplasmic and mitotic patterns should be reported as positive or negative. This report outlines the issues that impact on two major different reporting methods. Although it was appreciated by all participants that cytoplasmic and mitotic patterns are clinically relevant, implications for existing diagnostic/classification criteria for ANA-associated diseases in particular hampered a final consensus on this topic. Evidently, a more concerted action of all relevant stakeholders is required. Future ICAP workshops may help to facilitate this action.

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Title: International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results
Authors: Jan Damoiseaux
Carlos A. von Mühlen
Ignacio Garcia-De La Torre
Orlando Gabriel Carballo
Wilson de Melo Cruvinel
Paulo Luiz Carvalho Francescantonio
Marvin J. Fritzler
Manfred Herold
Tsuneyo Mimori
Minoru Satoh
Luis E. C. Andrade
Edward K. L. Chan
Karsten Conrad
Publication date: 01-12-2016
Publisher: Springer International Publishing
Published in: Autoimmunity Highlights / Issue 1/2016
Print ISSN: 2038-0305
Electronic ISSN: 2038-3274
DOI: https://doi.org/10.1007/s13317-016-0075-0

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