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Open Access 01-12-2022 | Coronavirus | Review

Effect of herbal compounds on coronavirus; a systematic review and meta-analysis

Authors: Mina Mobini Kesheh, Sara Shavandi, Niloofar Haeri Moghaddam, Moazzameh Ramezani, Fatemeh Ramezani

Published in: Virology Journal | Issue 1/2022

Abstract

Background

The new coronavirus (COVID-19) has been transmitted exponentially. Numerous studies have been performed in recent years that have shown the inhibitory effect of plant extracts or plant-derived compounds on the coronavirus family. In this study, we want to use systematic review and meta-analysis to answer the question, which herbal compound has been more effective?

Main body

The present study is based on the guidelines for conducting meta-analyzes. An extensive search was conducted in the electronic database, and based on the inclusion and exclusion criteria, articles were selected and data screening was done. Quality control of articles was performed. Data analysis was carried out in STATA software.

Conclusion

Due to the variety of study methods, definitive conclusions are not possible. However, in this study, we attempted to gather all the available evidence on the effect of plant compounds on SARS-COV-2 to be used for the development and use of promising antiviral agents against this virus and other coronaviruses. Trypthantrin, Sambucus extract, S. cusia extract, Boceprevir and Indigole B, dioica agglutinin urtica had a good effect on reducing the virus titer. Also among the compounds that had the greatest effect on virus inhibition, Saikosaponins B2, SaikosaponinsD, SaikosaponinsA and Phillyrin, had an acceptable selectivity index greater than 10. Andrographolide showed the highest selectivity index on SARS-COV-2. Our study confirmed insufficient data to support alkaloid compounds against SARS-COV-2, and the small number of studies that used alkaloid compounds was a limitation. It is recommended to investigate the effect of more alkaloid compounds against Corona virus.

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Title: Effect of herbal compounds on coronavirus; a systematic review and meta-analysis
Authors: Mina Mobini Kesheh
Sara Shavandi
Niloofar Haeri Moghaddam
Moazzameh Ramezani
Fatemeh Ramezani
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Coronavirus
Alkaloids
Alkaloids
Severe Acute Respiratory Syndrome Coronavirus
SARS-CoV-2
Published in: Virology Journal / Issue 1/2022
Electronic ISSN: 1743-422X
DOI: https://doi.org/10.1186/s12985-022-01808-z

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