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Virology Journal
Published in: Virology Journal 1/2016

Open Access 01-12-2016 | Review

Evasion of host antiviral innate immunity by HSV-1, an update

Authors: Chenhe Su, Guoqing Zhan, Chunfu Zheng

Published in: Virology Journal | Issue 1/2016

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Abstract

Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide range of antiviral proteins to control infection of incoming pathogens. In some cases, viral invasion also induces DNA damage response, autophagy, endoplasmic reticulum stress, cytoplasmic stress granules and other innate immune responses, which in turn affect viral infection. However, HSV-1 has evolved multiple strategies to evade host innate responses and facilitate its infection. In this review, we summarize the most recent findings on the molecular mechanisms utilized by HSV-1 to counteract host antiviral innate immune responses with specific focus on the type I IFN signal pathway.
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Metadata
Title
Evasion of host antiviral innate immunity by HSV-1, an update
Authors
Chenhe Su
Guoqing Zhan
Chunfu Zheng
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2016
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-016-0495-5

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