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Current Neurology and Neuroscience Reports

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01-12-2013 | Infection (J Berger, Section Editor)

Update on Herpes Virus Infections of the Nervous System

Authors: Israel Steiner, Felix Benninger

Published in: Current Neurology and Neuroscience Reports | Issue 12/2013

Abstract

Herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) are human neurotropic viruses that establish latent infection in dorsal root ganglia (DRG) for the entire life of the host. From the DRG they can reactivate to cause human morbidity and mortality. Although they vary, in part, in the clinical disorders they cause, and in their molecular structure, they share several features that govern the biology of their infection of the human nervous system. HSV-1 is the causative agent of encephalitis, corneal blindness, and several peripheral nervous system disorders; HSV-2 is responsible for meningoencephalitis in neonates and meningitis in adults. The biology of their ability to establish latency, maintain it for the entire life of the host, reactivate, and cause primary and recurrent disease is being studied in animal models and in humans. This review covers recent advances in understanding the biology and pathogenesis of HSV-related disease.

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Title: Update on Herpes Virus Infections of the Nervous System
Authors: Israel Steiner
Felix Benninger
Publication date: 01-12-2013
Publisher: Springer US
Published in: Current Neurology and Neuroscience Reports / Issue 12/2013
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-013-0414-8

At a glance: The STEP trials

Springer Medicine

Update on Herpes Virus Infections of the Nervous System

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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