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Virology Journal
Published in: Virology Journal 1/2015

Open Access 01-12-2015 | Research

Herpes simplex virus 1 UL41 protein abrogates the antiviral activity of hZAP by degrading its mRNA

Authors: Chenhe Su, Jie Zhang, Chunfu Zheng

Published in: Virology Journal | Issue 1/2015

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Abstract

Background

The zinc finger antiviral protein (ZAP) is a host restriction factor that inhibits the replication of various viruses by degradation of certain viral mRNA. However, previous study demonstrated that ectopic expression of rat ZAP did not suppress the replication of herpes simplex virus type 1 (HSV-1), an archetypal member of the alphaherpesvirus subfamily, and the molecular mechanism underneath is still illusive.

Results

Human ZAP (hZAP) does not suppress the replication of herpes simplex virus 1, and HSV-1 UL41 protein was identified as an antagonist of hZAP by degrading its mRNA. Infection of wild-type (WT), but not UL41-null mutant (R2621) virus, diminished the accumulation of hZAP to abrogate its antiviral activity. Moreover, ectopic expression of hZAP inhibited the replication of R2621 but not WT HSV-1.

Conclusion

HSV-1 UL41 was shown for the first time to evade the antiviral function of hZAP via its RNase activity.
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Metadata
Title
Herpes simplex virus 1 UL41 protein abrogates the antiviral activity of hZAP by degrading its mRNA
Authors
Chenhe Su
Jie Zhang
Chunfu Zheng
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2015
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-015-0433-y

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