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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2022

Open Access 01-12-2022 | Respiratory Microbiota | Review

Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora

Authors: Hourieh Sadrekarimi, Zhanna R. Gardanova, Morteza Bakhshesh, Farnoosh Ebrahimzadeh, Amirhossein Fakhre Yaseri, Lakshmi Thangavelu, Zahra Hasanpoor, Firoozeh Abolhasani Zadeh, Mohammad Saeed Kahrizi

Published in: Journal of Translational Medicine | Issue 1/2022

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Abstract

In recent years, there has been a greater emphasis on the impact of microbial populations inhabiting the gastrointestinal tract on human health and disease. According to the involvement of microbiota in modulating physiological processes (such as immune system development, vitamins synthesis, pathogen displacement, and nutrient uptake), any alteration in its composition and diversity (i.e., dysbiosis) has been linked to a variety of pathologies, including cancer. In this bidirectional relationship, colonization with various bacterial species is correlated with a reduced or elevated risk of certain cancers. Notably, the gut microflora could potentially play a direct or indirect role in tumor initiation and progression by inducing chronic inflammation and producing toxins and metabolites. Therefore, identifying the bacterial species involved and their mechanism of action could be beneficial in preventing the onset of tumors or controlling their advancement. Likewise, the microbial community affects anti-cancer approaches’ therapeutic potential and adverse effects (such as immunotherapy and chemotherapy). Hence, their efficiency should be evaluated in the context of the microbiome, underlining the importance of personalized medicine. In this review, we summarized the evidence revealing the microbiota's involvement in cancer and its mechanism. We also delineated how microbiota could predict colon carcinoma development or response to current treatments to improve clinical outcomes.
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Metadata
Title
Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora
Authors
Hourieh Sadrekarimi
Zhanna R. Gardanova
Morteza Bakhshesh
Farnoosh Ebrahimzadeh
Amirhossein Fakhre Yaseri
Lakshmi Thangavelu
Zahra Hasanpoor
Firoozeh Abolhasani Zadeh
Mohammad Saeed Kahrizi
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2022
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-022-03492-7

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