Top

Journal of Translational Medicine

Published in:

Open Access 01-12-2022 | Dementia | Review

The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis

Authors: Fatemeh Rajati, Nassim Ahmadi, Zahra Al-sadat Naghibzadeh, Mohsen Kazeminia

Published in: Journal of Translational Medicine | Issue 1/2022

Abstract

Background

Oropharyngeal dysphagia (OD) refers to any abnormality in the physiology of swallowing in the upper gastrointestinal tract, which leads to the related clinical complications, such as malnutrition, dehydration, and sever complication, such as aspiration pneumonia, suffocation, and eventually, premature death. The previous studies indicated a various range of prevalence of OD. The present systematic review and meta-analysis aimed to standardize the global prevalence of OD in different populations.

Methods

A systematic literature review was conducted using Embase, Scopus, PubMed, Web of Science (WoS) databases, and Google Scholar motor engine using related MeSH/Emtree and Free Text words, with no time limitation until November 2021. The heterogeneity among studies was quantified using I² index and the random effects model was used, due to the high heterogeneity among the results of studies included in the meta-analysis.

Results

The systematic literature search retrieved 2092 studies. After excluding the irrelevant studies, ultimately 27 articles with a sample size of 9841 were included in the meta-analysis. After combining the studies, the overall estimate of the global prevalence rate of OD was 43.8% (95% CI 33.3–54.9%) and the highest prevalence rate was estimated in Africa with 64.2% (95% CI 53.2–73.9%). Given the subgroup analysis based on the study population, the highest prevalence of OD was related to Dementia with 72.4% (95% CI 26.7–95.0%). The results of meta-regression indicated that the prevalence of OD has an increasing trend with the enhancement of year of publication and mean age.

Conclusion

The results of the present systematic review and meta-analysis revealed that the prevalence of OD is high in different populations and its trend has been increasing in recent years. Therefore, the appropriate strategies should be applied to reduce the prevalence of OD by finding its causation and monitoring at all levels, as well as providing feedback to hospitals.

Matsuyama S, Nakauma M, Funami T, Hori K, Ono T. Human physiological responses during swallowing of gel-type foods and its correlation with textural perception. Food Hydrocoll. 2021;111:106353.CrossRef

Suntrup-Krueger S, Muhle P, Kampe I, Egidi P, Ruck T, Lenze F, et al. Effect of capsaicinoids on neurophysiological, biochemical, and mechanical parameters of swallowing function. Neurotherapeutics. 2021. https://doi.org/10.1007/s13311-020-00996-2.CrossRefPubMedPubMedCentral

Yoon JH, Lee H-J. Perceptions on evaluation and treatment of swallowing disorders in speech-language pathologists. Phon Speech Sci. 2013;5(4):43–51.CrossRef

Ortega O, Martín A, Clavé P. Diagnosis and management of oropharyngeal dysphagia among older persons, state of the art. J Am Med Dir Assoc. 2017;18(7):576–82.PubMedCrossRef

Cichero JA, Altman KW. Definition, prevalence and burden of oropharyngeal dysphagia: a serious problem among older adults worldwide and the impact on prognosis and hospital resources. In: Stepping stones to living well with dysphagia. Basel: Karger Publishers; 2012.CrossRef

Audag N, Liistro G, Goubau C, Vandervelde L, Poncin W, Toussaint M, et al. Screening for oropharyngeal dysphagia in adult patients with neuromuscular diseases using the Sydney swallow questionnaire. Muscle Nerve. 2021. https://doi.org/10.1002/mus.27254.CrossRefPubMed

Cichero JA, Steele C, Duivestein J, Clavé P, Chen J, Kayashita J, et al. The need for international terminology and definitions for texture-modified foods and thickened liquids used in dysphagia management: foundations of a global initiative. Curr Phys Med Rehabil Rep. 2013;1(4):280–91.PubMedPubMedCentralCrossRef

Roldan-Vasco S, Orozco-Duque A, Suarez-Escudero JC, Orozco-Arroyave JR. Machine learning based analysis of speech dimensions in functional oropharyngeal dysphagia. Comput Methods Programs Biomed. 2021;208:106248.PubMedCrossRef

van der Maarel-Wierink CD, Vanobbergen JN, Bronkhorst EM, Schols JM, de Baat C. Meta-analysis of dysphagia and aspiration pneumonia in frail elders. J Dent Res. 2011;90(12):1398–404.PubMedCrossRef

10.

Baijens LW, Clavé P, Cras P, Ekberg O, Forster A, Kolb GF, et al. European Society for swallowing disorders–European Union geriatric medicine society white paper: oropharyngeal dysphagia as a geriatric syndrome. Clin Interv Aging. 2016;11:1403.PubMedPubMedCentralCrossRef

11.

Kertscher B, Speyer R, Fong E, Georgiou AM, Smith M. Prevalence of oropharyngeal dysphagia in the Netherlands: a telephone survey. Dysphagia. 2015;30(2):114–20.PubMedCrossRef

12.

Roden DF, Altman KW. Causes of dysphagia among different age groups: a systematic review of the literature. Otolaryngol Clin North Am. 2013;46(6):965–87.PubMedCrossRef

13.

Airoldi M, Garzaro M, Raimondo L, Pecorari G, Giordano C, Varetto A, et al. Functional and psychological evaluation after flap reconstruction plus radiotherapy in oral cancer. Head Neck. 2011;33(4):458–68.PubMedCrossRef

14.

Marinho D, Brandão S, Lopes J, Nascimento S, Vianna LG. Functional capacity and quality of life among elderly patients with or without dysphagia after an ischemic stroke. Rev Assoc Med Bras. 2010;56(6):738–43.

15.

Rodrigues B, Nóbrega AC, Sampaio M, Argolo N, Melo A. Silent saliva aspiration in Parkinson’s disease. Mov Disord. 2011;26(1):138–41.PubMedCrossRef

16.

Jones E, Speyer R, Kertscher B, Denman D, Swan K, Cordier R. Health-related quality of life and oropharyngeal dysphagia: a systematic review. Dysphagia. 2018;33(2):141–72.PubMedCrossRef

17.

Takizawa C, Gemmell E, Kenworthy J, Speyer R. A systematic review of the prevalence of oropharyngeal dysphagia in stroke, Parkinson’s disease, Alzheimer’s disease, head injury, and pneumonia. Dysphagia. 2016;31(3):434–41.PubMedCrossRef

18.

Miarons Font M, Rofes SL. Antipsychotic medication and oropharyngeal dysphagia: systematic review. Eur J Gastroenterol Hepatol. 2017;29(12):1332–9.PubMedCrossRef

19.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021. https://doi.org/10.1136/bmj.n160.CrossRefPubMedPubMedCentral

20.

Munn Z, Moola S, Lisy K, Riitano D, Tufanaru C. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. Int J Evid Based Healthc. 2015;13(3):147–53.PubMedCrossRef

21.

Watson DI, Lally CJ. Prevalence of symptoms and use of medication for gastroesophageal reflux in an Australian community. World J Surg. 2009;33(1):88–94.PubMedCrossRef

22.

Almeida TMd, Cola PC, Magnoni D, França JÍD, Silva RGd. Prevalence of oropharyngeal dysphagia in stroke after cardiac surgery. Revista CEFAC. 2015;17:1415–9.CrossRef

23.

Wolf U, Eckert S, Walter G, Wienke A, Bartel S, Plontke SK, et al. Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs. Sci Rep. 2021;11(1):1–14.CrossRef

24.

Ruth M, Månsson I, Sandberg N. The prevalence of symptoms suggestive of esophageal disorders. Scand J Gastroenterol. 1991;26(1):73–81.PubMedCrossRef

25.

Cabre M, Serra-Prat M, Palomera E, Almirall J, Pallares R, Clavé P. Prevalence and prognostic implications of dysphagia in elderly patients with pneumonia. Age Ageing. 2010;39(1):39–45.PubMedCrossRef

26.

Melgaard D, Baandrup U, Bøgsted M, Bendtsen MD, Hansen T. The prevalence of oropharyngeal dysphagia in Danish patients hospitalised with community-acquired pneumonia. Dysphagia. 2017;32(3):383–92.PubMedCrossRef

27.

Michel A, Vérin E, Gbaguidi X, Druesne L, Roca F, Chassagne P. Oropharyngeal dysphagia in community-dwelling older patients with dementia: prevalence and relationship with geriatric parameters. J Am Med Dir Assoc. 2018;19(9):770–4.PubMedCrossRef

28.

Espinosa-Val M, Martín-Martínez A, Graupera M, Arias O, Elvira A, Cabré M, et al. Prevalence, risk factors, and complications of oropharyngeal dysphagia in older patients with dementia. Nutrients. 2020;12(3):863.PubMedCentralCrossRef

29.

Holland G, Jayasekeran V, Pendleton N, Horan M, Jones M, Hamdy S. Prevalence and symptom profiling of oropharyngeal dysphagia in a community dwelling of an elderly population: a self-reporting questionnaire survey. Dis Esophagus. 2011;24(7):476–80.PubMedCrossRef

30.

Garcia-Peris P, Paron L, Velasco C, De la Cuerda C, Camblor M, Bretón I, et al. Long-term prevalence of oropharyngeal dysphagia in head and neck cancer patients: impact on quality of life. Clin Nutr. 2007;26(6):710–7.PubMedCrossRef

31.

Rofes L, Muriana D, Palomeras E, Vilardell N, Palomera E, Alvarez-Berdugo D, et al. Prevalence, risk factors and complications of oropharyngeal dysphagia in stroke patients: a cohort study. Neurogastroenterol Motil. 2018;30(8):e13338.CrossRef

32.

Mateos-Nozal J, Montero-Errasquín B, García ES, Rodríguez ER, Cruz-Jentoft AJ. High prevalence of oropharyngeal dysphagia in acutely hospitalized patients aged 80 years and older. J Am Med Dir Assoc. 2020;21(12):2008–11.PubMedCrossRef

33.

Falsetti P, Acciai C, Palilla R, Bosi M, Carpinteri F, Zingarelli A, et al. Oropharyngeal dysphagia after stroke: incidence, diagnosis, and clinical predictors in patients admitted to a neurorehabilitation unit. J Stroke Cerebrovasc Dis. 2009;18(5):329–35.PubMedCrossRef

34.

Lendinez-Mesa A, del Carmen D-G, Casero-Alcázar M, Grantham SJ, de la Torre-Montero JC, Fernandes-Ribeiro AS. Prevalence of oropharyngeal dysphagia in patients related with cerebrovascular disease at a neurorehabilitation unit. Revista Científica de la Sociedad de Enfermería Neurológica. 2017;45:3–8 (English ed).

35.

Serra-Prat M, Palomera M, Gomez C, Sar-Shalom D, Saiz A, Montoya JG, et al. Oropharyngeal dysphagia as a risk factor for malnutrition and lower respiratory tract infection in independently living older persons: a population-based prospective study. Age Ageing. 2012;41(3):376–81.PubMedCrossRef

36.

Clavé P. Prevalence and risk factors of oropharyngeal dysphagia in stroke patients. Ann Phys Rehabil Med. 2014;57:e263.CrossRef

37.

De Stefano A, Di Giovanni P, Kulamarva G, Gennachi S, Di Fonzo F, Sallustio V, et al. Oropharyngeal dysphagia in elderly population suffering from mild cognitive impairment and mild dementia: understanding the link. Am J Otolaryngol. 2020;41(4):102501.PubMedCrossRef

38.

Melgaard D, Rodrigo-Domingo M, Mørch MM. The prevalence of oropharyngeal dysphagia in acute geriatric patients. Geriatrics. 2018;3(2):15.PubMedCentralCrossRef

39.

Gonzalez Lindh M, Larsson L, Koyi H. Prevalence of oropharyngeal dysphagia in patients with stable COPD. J Oral Health Dent. 2017;1(S1):A002.

40.

Yang EJ, Kim MH, Lim J-Y, Paik N-J. Oropharyngeal dysphagia in a community-based elderly cohort: the Korean longitudinal study on health and aging. J Korean Med Sci. 2013;28(10):1534–49.PubMedPubMedCentralCrossRef

41.

Biglary M, Ghelichi L, Kamali M. Prevalence of oropharyngeal dysphagia and its predictive factors in patients with neurological diseases and head and neck surgery. Middle Eastern J Disabil Stud. 2019;9:113. https://doi.org/10.29252/mejds.0.0.40.CrossRef

42.

Kritzinger A, Da Costa MA, Graham MA, Krüger E. Prevalence and associated prenatal and perinatal risk factors for oropharyngeal dysphagia in high-risk neonates in a South African hospital. S Afr J Commun Disord. 2019;66(1):1–8.

43.

Chiocca J, Olmos J, Salis G, Soifer L, Higa R, Marcolongo M, et al. Prevalence, clinical spectrum and atypical symptoms of gastro-oesophageal reflux in Argentina: a nationwide population-based study. Aliment Pharmacol Ther. 2005;22(4):331–42.PubMedCrossRef

44.

Jacinto-Scudeiro LA, Machado GD, Ayres A, Burguêz D, Polese-Bonatto M, González-Salazar C, et al. Prevalence of oropharyngeal dysphagia in hereditary spastic paraplegias. Arq Neuropsiquiatr. 2020;77:843–7.CrossRef

45.

Delevatti C, Rodrigues EdC, Almeida STd, Santos KWd. Prevalence and risk factors for oropharyngeal dysphagia in fragile older adults with orthopedic fractures. Audiol-Commun Res. 2020. https://doi.org/10.1590/2317-6431-2020-2388.CrossRef

46.

Holmes SR, Sabel AL, Gaudiani JL, Gudridge T, Brinton JT, Mehler PS. Prevalence and management of oropharyngeal dysphagia in patients with severe anorexia nervosa: a large retrospective review. Int J Eat Disord. 2016;49(2):159–66.PubMedCrossRef

47.

Benfer KA, Weir KA, Bell KL, Ware RS, Davies PS, Boyd RN. Oropharyngeal dysphagia and cerebral palsy. Pediatrics. 2017. https://doi.org/10.1542/peds.2017-0731.CrossRefPubMed

48.

Camacho M, Certal V, Abdullatif J, Zaghi S, Ruoff CM, Capasso R, et al. Myofunctional therapy to treat obstructive sleep apnea: a systematic review and meta-analysis. Sleep. 2015;38(5):669–75.PubMedPubMedCentralCrossRef

49.

Jun H-J, Kim K-J, Nam K-W, Kim C-H. Effects of breathing exercises on lung capacity and muscle activities of elderly smokers. J Phys Ther Sci. 2016;28(6):1681–5.PubMedPubMedCentralCrossRef

50.

Jablu DS, Hosseini RA. Effects of resistance and endurance exercises on serum androgens, cortisol and lactate in menopause women. Iran J Health Phys Act. 2012;3(1):21–9.

51.

Chahine LM, Amara AW, Videnovic A. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson’s disease from 2005 to 2015. Sleep Med Rev. 2017;35:33–50.PubMedCrossRef

52.

Lajoie AC, Lafontaine A-L, Kimoff RJ, Kaminska M. Obstructive sleep apnea in neurodegenerative disorders: current evidence in support of benefit from sleep apnea treatment. J Clin Med. 2020;9(2):297.PubMedCentralCrossRef

53.

Sun A-P, Liu N, Zhang Y-S, Zhao H-Y, Liu X-L. The relationship between obstructive sleep apnea and Parkinson’s disease: a systematic review and meta-analysis. Neurol Sci. 2020;41(5):1153–62.PubMedCrossRef

54.

Loke YK, Brown JWL, Kwok CS, Niruban A, Myint PK. Association of obstructive sleep apnea with risk of serious cardiovascular events: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes. 2012;5(5):720–8.PubMedCrossRef

55.

Tawfik GM, Alshareef A, Mostafa EM, Khaled S, Hmeda AB, Abdelwahed KA, et al. Association between radiotherapy and obstructive sleep apnea in cancer patients: a systematic review and meta-analysis. Am Soc Clin Oncol. 2019. https://doi.org/10.1200/JCO.2019.37.15.CrossRef

56.

Grande G, Haaksma ML, Rizzuto D, Melis RJ, Marengoni A, Onder G, et al. Co-occurrence of cognitive impairment and physical frailty, and incidence of dementia: systematic review and meta-analysis. Neurosci Biobehav Rev. 2019;107:96–103.PubMedCrossRef

57.

Abdollahpour I, Nedjat S, Noroozian M, Golestan B, Majdzadeh R. Development of a caregiver burden questionnaire for the patients with dementia in Iran. Int J Prev Med. 2010;1(4):233.PubMedPubMedCentral

58.

Liu S, Li C, Shi Z, Wang X, Zhou Y, Liu S, et al. Caregiver burden and prevalence of depression, anxiety and sleep disturbances in Alzheimer’s disease caregivers in China. J Clin Nurs. 2017;26(9–10):1291–300.PubMedCrossRef

59.

Milen MT, Nicholas DB. Examining transitions from youth to adult services for young persons with autism. Soc Work Health Care. 2017;56(7):636–48.CrossRef

60.

Meng P-p, Zhang S-c, Han C, Wang Q, Bai G-t, Yue S-w. The occurrence rate of swallowing disorders after stroke patients in Asia: a PRISMA-compliant systematic review and meta-analysis. J Stroke Cerebrovasc Dis. 2020;29(10):105113.PubMedCrossRef

61.

Kaddumukasa M, Mugenyi L, Kaddumukasa MN, Ddumba E, Devereaux M, Furlan A, et al. Prevalence and incidence of neurological disorders among adult Ugandans in rural and urban Mukono district; a cross-sectional study. BMC Neurol. 2016;16(1):1–9.CrossRef

62.

Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors J, Culebras A, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American heart association/American stroke association. Stroke. 2013;44(7):2064–89.PubMedCrossRef

63.

Chen Z, Venkat P, Seyfried D, Chopp M, Yan T, Chen J. Brain–heart interaction: cardiac complications after stroke. Circ Res. 2017;121(4):451–68.PubMedPubMedCentralCrossRef

64.

Kim B-R, Lee J, Sohn MK, Kim DY, Lee S-G, Shin Y-I, et al. Risk factors and functional impact of medical complications in stroke. Ann Rehabil Med. 2017;41(5):753.PubMedPubMedCentralCrossRef

65.

Kumar S, Selim MH, Caplan LR. Medical complications after stroke. Lancet Neurol. 2010;9(1):105–18.PubMedCrossRef

66.

Menezes KK, Nascimento LR, Ada L, Polese JC, Avelino PR, Teixeira-Salmela LF. Respiratory muscle training increases respiratory muscle strength and reduces respiratory complications after stroke: a systematic review. J Physiother. 2016;62(3):138–44.PubMedCrossRef

Title: The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis
Authors: Fatemeh Rajati
Nassim Ahmadi
Zahra Al-sadat Naghibzadeh
Mohsen Kazeminia
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Dementia
Dementia
Dysphagia
Dysphagia
Dysphagia
Published in: Journal of Translational Medicine / Issue 1/2022
Electronic ISSN: 1479-5876
DOI: https://doi.org/10.1186/s12967-022-03380-0

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusion

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2022

Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination

Combination of whole body cryotherapy with static stretching exercises reduces fatigue and improves functioning of the autonomic nervous system in Chronic Fatigue Syndrome

Alpha-ketoglutarate ameliorates abdominal aortic aneurysm via inhibiting PXDN/HOCL/ERK signaling pathways

The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics

XGBoost-based and tumor-immune characterized gene signature for the prediction of metastatic status in breast cancer

Effects of focus training on heart rate variability in post-stroke fatigue patients

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page