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Open Access 01-12-2021 | COVID-19 | Review

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Authors: Klaus J. Wirth, Carmen Scheibenbogen, Friedemann Paul

Published in: Journal of Translational Medicine | Issue 1/2021

Abstract

There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In this paper we deduce the pathomechanisms resulting in central nervous pathology and the myriad of neurocognitive symptoms. We outline tentative mechanisms of impaired cerebral blood flow, increase in intracranial pressure and central adrenergic hyperactivity and how they can well explain the key symptoms of cognitive impairment, brain fog, headache, hypersensitivity, sleep disturbances and dysautonomia.

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Title: An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Authors: Klaus J. Wirth
Carmen Scheibenbogen
Friedemann Paul
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: COVID-19
Headache
Fatigue
Intracranial Hypertension
Published in: Journal of Translational Medicine / Issue 1/2021
Electronic ISSN: 1479-5876
DOI: https://doi.org/10.1186/s12967-021-03143-3

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An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Abstract

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