Skip to main content
Top
Published in: Current Rheumatology Reports 2/2019

01-02-2019 | Fatigue | Chronic Pain (R Staud, Section Editor)

The Invisible Burden of Chronic Fatigue in the Community: a Narrative Review

Authors: Scott J. Fatt, Erin Cvejic, Andrew R. Lloyd, Ute Vollmer-Conna, Jessica Elise Beilharz

Published in: Current Rheumatology Reports | Issue 2/2019

Login to get access

Abstract

Purpose of Review

Unexplained fatigue is commonly reported in the general population, with varying severity. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) sits at the extreme of the fatigue continuum, yet more individuals experience unexplained prolonged fatigue (1–6-month duration) or chronic fatigue (> 6 months) that, although debilitating, does not fulfil ME/CFS criteria. This review examines the empirical literature comparing symptoms for those with prolonged fatigue, chronic fatigue and ME/CFS.

Recent Findings

Substantial overlap of self-reported psychological, physical and functional impairments exists between chronic fatigue and ME/CFS. The conversion rate from prolonged or chronic fatigue to ME/CFS is not understood. Current research has failed to uncover factors accounting for differences in fatigue trajectories, nor incorporate comprehensive, longitudinal assessments extending beyond self-reported symptoms.

Summary

Distinguishing factors between prolonged fatigue, chronic fatigue and ME/CFS remain poorly understood, highlighting a need for longitudinal studies integrating biopsychosocial approaches to inform early management and targeted rehabilitation strategies.
Literature
1.
go back to reference van’t Leven M, et al. Fatigue and chronic fatigue syndrome-like complaints in the general population. Eur J Pub Health. 2009;20(3):251–7.CrossRef van’t Leven M, et al. Fatigue and chronic fatigue syndrome-like complaints in the general population. Eur J Pub Health. 2009;20(3):251–7.CrossRef
2.
go back to reference Ricci JA, Chee E, Lorandeau AL, Berger J. Fatigue in the US workforce: prevalence and implications for lost productive work time. J Occup Environ Med. 2007;49(1):1–10.PubMedCrossRef Ricci JA, Chee E, Lorandeau AL, Berger J. Fatigue in the US workforce: prevalence and implications for lost productive work time. J Occup Environ Med. 2007;49(1):1–10.PubMedCrossRef
3.
go back to reference Rupp I, Boshuizen HC, Jacobi CE, Dinant HJ, van den Bos GAM. Impact of fatigue on health-related quality of life in rheumatoid arthritis. Arthritis Rheum. 2004;51(4):578–85.PubMedCrossRef Rupp I, Boshuizen HC, Jacobi CE, Dinant HJ, van den Bos GAM. Impact of fatigue on health-related quality of life in rheumatoid arthritis. Arthritis Rheum. 2004;51(4):578–85.PubMedCrossRef
4.
go back to reference Finsterer J, Mahjoub SZ. Fatigue in healthy and diseased individuals. Am J Hosp Palliat Care. 2014;31(5):562–75.PubMedCrossRef Finsterer J, Mahjoub SZ. Fatigue in healthy and diseased individuals. Am J Hosp Palliat Care. 2014;31(5):562–75.PubMedCrossRef
5.
go back to reference Wilson J, Morgan S, Magin PJ, van Driel M. Fatigue—a rational approach to investigation. Aust Fam Physician. 2014;43(7):457–61.PubMed Wilson J, Morgan S, Magin PJ, van Driel M. Fatigue—a rational approach to investigation. Aust Fam Physician. 2014;43(7):457–61.PubMed
6.
go back to reference American Psychiatric Association, Diagnostic and statistical manual of mental disorders (DSM-5®). 2013: American Psychiatric Pub. American Psychiatric Association, Diagnostic and statistical manual of mental disorders (DSM-5®). 2013: American Psychiatric Pub.
7.
go back to reference Fukuda K, Dobbins JG, Wilson LJ, Dunn RA, Wilcox K, Smallwood D. An epidemiologic study of fatigue with relevance for the chronic fatigue syndrome. J Psychiatr Res. 1997;31(1):19–29.PubMedCrossRef Fukuda K, Dobbins JG, Wilson LJ, Dunn RA, Wilcox K, Smallwood D. An epidemiologic study of fatigue with relevance for the chronic fatigue syndrome. J Psychiatr Res. 1997;31(1):19–29.PubMedCrossRef
8.
go back to reference Steele L, Dobbins JG, Fukuda K, Reyes M, Randall B, Koppelman M, et al. The epidemiology of chronic fatigue in San Francisco. Am J Med. 1998;105(3):83S–90S.PubMedCrossRef Steele L, Dobbins JG, Fukuda K, Reyes M, Randall B, Koppelman M, et al. The epidemiology of chronic fatigue in San Francisco. Am J Med. 1998;105(3):83S–90S.PubMedCrossRef
9.
go back to reference Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994;121(12):953–9.PubMedCrossRef Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994;121(12):953–9.PubMedCrossRef
10.
go back to reference Brurberg KG, Fønhus MS, Larun L, Flottorp S, Malterud K. Case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review. BMJ Open. 2014;4(2):e003973.PubMedPubMedCentralCrossRef Brurberg KG, Fønhus MS, Larun L, Flottorp S, Malterud K. Case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review. BMJ Open. 2014;4(2):e003973.PubMedPubMedCentralCrossRef
11.
go back to reference McCrone P, et al. The economic cost of chronic fatigue and chronic fatigue syndrome in UK primary care. Psychol Med. 2003;33(2):253–61.PubMedCrossRef McCrone P, et al. The economic cost of chronic fatigue and chronic fatigue syndrome in UK primary care. Psychol Med. 2003;33(2):253–61.PubMedCrossRef
12.
go back to reference Sabes-Figuera R, McCrone P, Hurley M, King M, Donaldson AN, Ridsdale L. The hidden cost of chronic fatigue to patients and their families. BMC Health Serv Res. 2010;10(1):56.PubMedPubMedCentralCrossRef Sabes-Figuera R, McCrone P, Hurley M, King M, Donaldson AN, Ridsdale L. The hidden cost of chronic fatigue to patients and their families. BMC Health Serv Res. 2010;10(1):56.PubMedPubMedCentralCrossRef
13.
go back to reference Lloyd A, Pender H. The economic impact of chronic fatigue syndrome. Med J Aust. 1992;157(9):599–601.PubMedCrossRef Lloyd A, Pender H. The economic impact of chronic fatigue syndrome. Med J Aust. 1992;157(9):599–601.PubMedCrossRef
14.
go back to reference Reynolds KJ, Vernon SD, Bouchery E, Reeves WC. The economic impact of chronic fatigue syndrome. Cost effectiveness and resource allocation. 2004;2(1):4.PubMedCrossRefPubMedCentral Reynolds KJ, Vernon SD, Bouchery E, Reeves WC. The economic impact of chronic fatigue syndrome. Cost effectiveness and resource allocation. 2004;2(1):4.PubMedCrossRefPubMedCentral
15.
go back to reference Whiting P, Bagnall AM, Sowden AJ, Cornell JE, Mulrow CD, Ramírez G. Interventions for the treatment and management of chronic fatigue syndrome: a systematic review. Jama. 2001;286(11):1360–8.PubMedCrossRef Whiting P, Bagnall AM, Sowden AJ, Cornell JE, Mulrow CD, Ramírez G. Interventions for the treatment and management of chronic fatigue syndrome: a systematic review. Jama. 2001;286(11):1360–8.PubMedCrossRef
16.
go back to reference Joyce J, Hotopf M, Wessely S. The prognosis of chronic fatigue and chronic fatigue syndrome: a systematic review. QJM. 1997;90(3):223–33.PubMedCrossRef Joyce J, Hotopf M, Wessely S. The prognosis of chronic fatigue and chronic fatigue syndrome: a systematic review. QJM. 1997;90(3):223–33.PubMedCrossRef
17.
go back to reference Malouff JM, Thorsteinsson EB, Rooke SE, Bhullar N, Schutte NS. Efficacy of cognitive behavioral therapy for chronic fatigue syndrome: a meta-analysis. Clin Psychol Rev. 2008;28(5):736–45.PubMedCrossRef Malouff JM, Thorsteinsson EB, Rooke SE, Bhullar N, Schutte NS. Efficacy of cognitive behavioral therapy for chronic fatigue syndrome: a meta-analysis. Clin Psychol Rev. 2008;28(5):736–45.PubMedCrossRef
18.
go back to reference Castell BD, Kazantzis N, Moss-Morris RE. Cognitive behavioral therapy and graded exercise for chronic fatigue syndrome: a meta-analysis. Clin Psychol Sci Pract. 2011;18(4):311–24.CrossRef Castell BD, Kazantzis N, Moss-Morris RE. Cognitive behavioral therapy and graded exercise for chronic fatigue syndrome: a meta-analysis. Clin Psychol Sci Pract. 2011;18(4):311–24.CrossRef
19.
go back to reference Romano GF, et al. Fibromyalgia and chronic fatigue: the underlying biology and related theoretical issues. Adv Psychosom Med. 2015;34:61–77.PubMedCrossRef Romano GF, et al. Fibromyalgia and chronic fatigue: the underlying biology and related theoretical issues. Adv Psychosom Med. 2015;34:61–77.PubMedCrossRef
20●●.
go back to reference Lloyd AR, Meer JW. The long wait for a breakthrough in chronic fatigue syndrome. BMJ. 2015;350:h2087 An editorial discussing the current limitations of research and current understanding of therapies for ME/CFS.PubMedCrossRef Lloyd AR, Meer JW. The long wait for a breakthrough in chronic fatigue syndrome. BMJ. 2015;350:h2087 An editorial discussing the current limitations of research and current understanding of therapies for ME/CFS.PubMedCrossRef
21.
go back to reference Hickie IB, et al. Fatigue in selected primary care settings: sociodemographic and psychiatric correlates. Med J Aust. 1996;164(10):585–8.PubMedCrossRef Hickie IB, et al. Fatigue in selected primary care settings: sociodemographic and psychiatric correlates. Med J Aust. 1996;164(10):585–8.PubMedCrossRef
22.
go back to reference Skapinakis P, Lewis G, Mavreas V. Temporal relations between unexplained fatigue and depression: longitudinal data from an international study in primary care. Psychosom Med. 2004;66(3):330–5.PubMedCrossRef Skapinakis P, Lewis G, Mavreas V. Temporal relations between unexplained fatigue and depression: longitudinal data from an international study in primary care. Psychosom Med. 2004;66(3):330–5.PubMedCrossRef
23.
go back to reference Hickie I, et al. The temporal stability and co-morbidity of prolonged fatigue: a longitudinal study in primary care. Psychol Med. 1999;29(4):855–61.PubMedCrossRef Hickie I, et al. The temporal stability and co-morbidity of prolonged fatigue: a longitudinal study in primary care. Psychol Med. 1999;29(4):855–61.PubMedCrossRef
24.
go back to reference Jason LA, Jordan KM, Richman JA, Rademaker AW, Huang CF, Mccready W, et al. A community-based study of prolonged fatigue and chronic fatigue. J Health Psychol. 1999;4(1):9–26.PubMedCrossRef Jason LA, Jordan KM, Richman JA, Rademaker AW, Huang CF, Mccready W, et al. A community-based study of prolonged fatigue and chronic fatigue. J Health Psychol. 1999;4(1):9–26.PubMedCrossRef
25.
go back to reference Martin A, Chalder T, Rief W, Braehler E. The relationship between chronic fatigue and somatization syndrome: a general population survey. J Psychosom Res. 2007;63(2):147–56.PubMedCrossRef Martin A, Chalder T, Rief W, Braehler E. The relationship between chronic fatigue and somatization syndrome: a general population survey. J Psychosom Res. 2007;63(2):147–56.PubMedCrossRef
26.
go back to reference Solomon L, Nisenbaum R, Reyes M, Papanicolaou DA, Reeves WC. Functional status of persons with chronic fatigue syndrome in the Wichita, Kansas, population. Health Qual Life Outcomes. 2003;1(1):48.PubMedPubMedCentralCrossRef Solomon L, Nisenbaum R, Reyes M, Papanicolaou DA, Reeves WC. Functional status of persons with chronic fatigue syndrome in the Wichita, Kansas, population. Health Qual Life Outcomes. 2003;1(1):48.PubMedPubMedCentralCrossRef
27.
go back to reference Buchwald D, Pearlman T, Umali J, Schmaling K, Katon W. Functional status in patients with chronic fatigue syndrome, other fatiguing illnesses, and healthy individuals. Am J Med. 1996;101(4):364–70.PubMedCrossRef Buchwald D, Pearlman T, Umali J, Schmaling K, Katon W. Functional status in patients with chronic fatigue syndrome, other fatiguing illnesses, and healthy individuals. Am J Med. 1996;101(4):364–70.PubMedCrossRef
28.
go back to reference Buchwald D, Umali P, Umali J, Kith P, Pearlman T, Komaroff AL. Chronic fatigue and the chronic fatigue syndrome: prevalence in a Pacific Northwest health care system. Ann Intern Med. 1995;123(2):81–8.PubMedCrossRef Buchwald D, Umali P, Umali J, Kith P, Pearlman T, Komaroff AL. Chronic fatigue and the chronic fatigue syndrome: prevalence in a Pacific Northwest health care system. Ann Intern Med. 1995;123(2):81–8.PubMedCrossRef
29.
go back to reference Skapinakis P, Lewis G, Meltzer H. Clarifying the relationship between unexplained chronic fatigue and psychiatric morbidity: results from a community survey in Great Britain. Int Rev Psychiatry. 2003;15(1–2):57–64.PubMedCrossRef Skapinakis P, Lewis G, Meltzer H. Clarifying the relationship between unexplained chronic fatigue and psychiatric morbidity: results from a community survey in Great Britain. Int Rev Psychiatry. 2003;15(1–2):57–64.PubMedCrossRef
30.
go back to reference Sulheim, D., et al., Cognitive dysfunction in adolescents with chronic fatigue: a cross-sectional study. Archives of disease in childhood, 2015: p. archdischild-2014-306764. Sulheim, D., et al., Cognitive dysfunction in adolescents with chronic fatigue: a cross-sectional study. Archives of disease in childhood, 2015: p. archdischild-2014-306764.
31.
go back to reference Evengård B, et al. Differences between patients with chronic fatigue syndrome and with chronic fatigue at an infectious disease clinic in Stockholm, Sweden. Psychiatry Clin Neurosci. 2003;57(4):361–8.PubMedCrossRef Evengård B, et al. Differences between patients with chronic fatigue syndrome and with chronic fatigue at an infectious disease clinic in Stockholm, Sweden. Psychiatry Clin Neurosci. 2003;57(4):361–8.PubMedCrossRef
32●.
go back to reference De Gucht V, et al. Differences in physical and psychosocial characteristics between CFS and fatigued non-CFS patients, a case-control study. Int J Behav Med. 2016;23(5):589–94 A recent comparison of patients with ME/CFS, and fatigued patients who do not meet diagnostic criteria for ME/CFS.PubMedPubMedCentralCrossRef De Gucht V, et al. Differences in physical and psychosocial characteristics between CFS and fatigued non-CFS patients, a case-control study. Int J Behav Med. 2016;23(5):589–94 A recent comparison of patients with ME/CFS, and fatigued patients who do not meet diagnostic criteria for ME/CFS.PubMedPubMedCentralCrossRef
33.
go back to reference Darbishire L, Ridsdale L, Seed P. Distinguishing patients with chronic fatigue from those with chronic fatigue syndrome: a diagnostic study in UK primary care. Br J Gen Pract. 2003;53(491):441–5.PubMedPubMedCentral Darbishire L, Ridsdale L, Seed P. Distinguishing patients with chronic fatigue from those with chronic fatigue syndrome: a diagnostic study in UK primary care. Br J Gen Pract. 2003;53(491):441–5.PubMedPubMedCentral
34.
go back to reference Binder LM, Storzbach D, Anger WK, Campbell KA, Rohlman DS, of the Portland Environmental O, et al. Subjective cognitive complaints, affective distress, and objective cognitive performance in Persian Gulf War veterans. Arch Clin Neuropsychol. 1999;14(6):531–6.PubMedCrossRef Binder LM, Storzbach D, Anger WK, Campbell KA, Rohlman DS, of the Portland Environmental O, et al. Subjective cognitive complaints, affective distress, and objective cognitive performance in Persian Gulf War veterans. Arch Clin Neuropsychol. 1999;14(6):531–6.PubMedCrossRef
35.
go back to reference Kinsinger SW, Lattie E, Mohr DC. Relationship between depression, fatigue, subjective cognitive impairment, and objective neuropsychological functioning in patients with multiple sclerosis. Neuropsychology. 2010;24(5):573–80.PubMedPubMedCentralCrossRef Kinsinger SW, Lattie E, Mohr DC. Relationship between depression, fatigue, subjective cognitive impairment, and objective neuropsychological functioning in patients with multiple sclerosis. Neuropsychology. 2010;24(5):573–80.PubMedPubMedCentralCrossRef
36.
go back to reference Weis J, Poppelreuter M, Bartsch H. Cognitive deficits as long-term side-effects of adjuvant therapy in breast cancer patients:‘subjective’complaints and ‘objective’neuropsychological test results. Psycho-Oncology. 2009;18(7):775–82.PubMedCrossRef Weis J, Poppelreuter M, Bartsch H. Cognitive deficits as long-term side-effects of adjuvant therapy in breast cancer patients:‘subjective’complaints and ‘objective’neuropsychological test results. Psycho-Oncology. 2009;18(7):775–82.PubMedCrossRef
37.
go back to reference Cockshell SJ, Mathias JL. Cognitive functioning in people with chronic fatigue syndrome: a comparison between subjective and objective measures. Neuropsychology. 2014;28(3):394–405.PubMedCrossRef Cockshell SJ, Mathias JL. Cognitive functioning in people with chronic fatigue syndrome: a comparison between subjective and objective measures. Neuropsychology. 2014;28(3):394–405.PubMedCrossRef
38.
go back to reference Wearden A, Appleby L. Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS). Psychol Med. 1997;27(1):81–90.PubMedCrossRef Wearden A, Appleby L. Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS). Psychol Med. 1997;27(1):81–90.PubMedCrossRef
39.
go back to reference Cvejic E, Birch RC, Vollmer-Conna U. Cognitive dysfunction in chronic fatigue syndrome: a review of recent evidence. Curr Rheumatol Rep. 2016;18(5):24.PubMedCrossRef Cvejic E, Birch RC, Vollmer-Conna U. Cognitive dysfunction in chronic fatigue syndrome: a review of recent evidence. Curr Rheumatol Rep. 2016;18(5):24.PubMedCrossRef
40.
go back to reference Meeus, M., et al. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. In Seminars in arthritis and rheumatism. 2013. Elsevier. Meeus, M., et al. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. In Seminars in arthritis and rheumatism. 2013. Elsevier.
41.
go back to reference Martínez-Martínez L-A, Mora T, Vargas A, Fuentes-Iniestra M, Martínez-Lavín M. Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies. JCR: J Clin Rheumatol. 2014;20(3):146–50.PubMed Martínez-Martínez L-A, Mora T, Vargas A, Fuentes-Iniestra M, Martínez-Lavín M. Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies. JCR: J Clin Rheumatol. 2014;20(3):146–50.PubMed
42.
go back to reference Togo F, Natelson BH. Heart rate variability during sleep and subsequent sleepiness in patients with chronic fatigue syndrome. Auton Neurosci. 2013;176(1–2):85–90.PubMedPubMedCentralCrossRef Togo F, Natelson BH. Heart rate variability during sleep and subsequent sleepiness in patients with chronic fatigue syndrome. Auton Neurosci. 2013;176(1–2):85–90.PubMedPubMedCentralCrossRef
43.
go back to reference Cauwenbergh D, et al. Malfunctioning of the autonomic nervous system in patients with chronic fatigue syndrome: a systematic literature review. Eur J Clin Investig. 2014;44(5):516–26.CrossRef Cauwenbergh D, et al. Malfunctioning of the autonomic nervous system in patients with chronic fatigue syndrome: a systematic literature review. Eur J Clin Investig. 2014;44(5):516–26.CrossRef
44.
go back to reference Beaumont A, Burton AR, Lemon J, Bennett BK, Lloyd A, Vollmer-Conna U. Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome. PLoS One. 2012;7(11):e49518.PubMedPubMedCentralCrossRef Beaumont A, Burton AR, Lemon J, Bennett BK, Lloyd A, Vollmer-Conna U. Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome. PLoS One. 2012;7(11):e49518.PubMedPubMedCentralCrossRef
46.
go back to reference Burton A, et al. Reduced heart rate variability predicts poor sleep quality in a case–control study of chronic fatigue syndrome. Exp Brain Res. 2010;204(1):71–8.PubMedCrossRef Burton A, et al. Reduced heart rate variability predicts poor sleep quality in a case–control study of chronic fatigue syndrome. Exp Brain Res. 2010;204(1):71–8.PubMedCrossRef
47.
go back to reference Hurwitz BE, Coryell VT, Parker M, Martin P, LaPerriere A, Klimas NG, et al. Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function. Clin Sci. 2009;118(2):125–35.CrossRef Hurwitz BE, Coryell VT, Parker M, Martin P, LaPerriere A, Klimas NG, et al. Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function. Clin Sci. 2009;118(2):125–35.CrossRef
48.
go back to reference Stewart JM. Chronic fatigue syndrome: comments on deconditioning, blood volume and resulting cardiac function. Clin Sci. 2009;118(2):121–3.CrossRef Stewart JM. Chronic fatigue syndrome: comments on deconditioning, blood volume and resulting cardiac function. Clin Sci. 2009;118(2):121–3.CrossRef
49.
go back to reference Fortney SM, Schneider VS, Greenleaf JE. The physiology of bed rest. Handbook of Physiology. Environ Physiol. 1996:889–939. Fortney SM, Schneider VS, Greenleaf JE. The physiology of bed rest. Handbook of Physiology. Environ Physiol. 1996:889–939.
50.
go back to reference Baker R, Shaw E. Diagnosis and management of chronic fatigue syndrome or myalgic encephalomyelitis (or encephalopathy): summary of NICE guidance. BMJ: Br Med J. 2007;335(7617):446–8.CrossRef Baker R, Shaw E. Diagnosis and management of chronic fatigue syndrome or myalgic encephalomyelitis (or encephalopathy): summary of NICE guidance. BMJ: Br Med J. 2007;335(7617):446–8.CrossRef
51.
go back to reference White PD, Goldsmith KA, Johnson AL, Potts L, Walwyn R, DeCesare J, et al. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet. 2011;377(9768):823–36.PubMedPubMedCentralCrossRef White PD, Goldsmith KA, Johnson AL, Potts L, Walwyn R, DeCesare J, et al. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet. 2011;377(9768):823–36.PubMedPubMedCentralCrossRef
52.
go back to reference Price, J.R., et al., Cognitive behaviour therapy for chronic fatigue syndrome in adults. The Cochrane Library, 2008. Price, J.R., et al., Cognitive behaviour therapy for chronic fatigue syndrome in adults. The Cochrane Library, 2008.
53.
go back to reference Larun L, et al. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev. 2017;4. Larun L, et al. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev. 2017;4.
54.
go back to reference Cairns R, Hotopf M. A systematic review describing the prognosis of chronic fatigue syndrome. Occup Med. 2005;55(1):20–31.CrossRef Cairns R, Hotopf M. A systematic review describing the prognosis of chronic fatigue syndrome. Occup Med. 2005;55(1):20–31.CrossRef
55.
go back to reference White PD, Grover SA, Kangro HO, Thomas JM, Amess J, Clare AW. The validity and reliability of the fatigue syndrome that follows glandular fever. Psychol Med. 1995;25(5):917–24.PubMedCrossRef White PD, Grover SA, Kangro HO, Thomas JM, Amess J, Clare AW. The validity and reliability of the fatigue syndrome that follows glandular fever. Psychol Med. 1995;25(5):917–24.PubMedCrossRef
56.
go back to reference Hickie I, Davenport T, Wakefield D, Vollmer-Conna U, Cameron B, Vernon SD, et al. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. Bmj. 2006;333(7568):575.PubMedPubMedCentralCrossRef Hickie I, Davenport T, Wakefield D, Vollmer-Conna U, Cameron B, Vernon SD, et al. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. Bmj. 2006;333(7568):575.PubMedPubMedCentralCrossRef
57.
go back to reference Katz BZ, Shiraishi Y, Mears CJ, Binns HJ, Taylor R. Chronic fatigue syndrome after infectious mononucleosis in adolescents. Pediatrics. 2009;124(1):189–93.PubMedCrossRef Katz BZ, Shiraishi Y, Mears CJ, Binns HJ, Taylor R. Chronic fatigue syndrome after infectious mononucleosis in adolescents. Pediatrics. 2009;124(1):189–93.PubMedCrossRef
58.
go back to reference Candy B, et al. Predictors of fatigue following the onset of infectious mononucleosis. Psychol Med. 2003;33(5):847–55.PubMedCrossRef Candy B, et al. Predictors of fatigue following the onset of infectious mononucleosis. Psychol Med. 2003;33(5):847–55.PubMedCrossRef
59.
go back to reference Buchwald DS, Rea TD, Katon WJ, Russo JE, Ashley RL. Acute infectious mononucleosis: characteristics of patients who report failure to recover. Am J Med. 2000;109(7):531–7.PubMedCrossRef Buchwald DS, Rea TD, Katon WJ, Russo JE, Ashley RL. Acute infectious mononucleosis: characteristics of patients who report failure to recover. Am J Med. 2000;109(7):531–7.PubMedCrossRef
60.
go back to reference Vollmer-Conna U, Piraino BF, Cameron B, Davenport T, Hickie I, Wakefield D, et al. Cytokine polymorphisms have a synergistic effect on severity of the acute sickness response to infection. Clin Infect Dis. 2008;47(11):1418–25.PubMedCrossRef Vollmer-Conna U, Piraino BF, Cameron B, Davenport T, Hickie I, Wakefield D, et al. Cytokine polymorphisms have a synergistic effect on severity of the acute sickness response to infection. Clin Infect Dis. 2008;47(11):1418–25.PubMedCrossRef
61.
go back to reference Van Cauwenbergh D, et al. Malfunctioning of the autonomic nervous system in patients with chronic fatigue syndrome: a systematic literature review. Eur J Clin Investig. 2014;44(5):516–26.CrossRef Van Cauwenbergh D, et al. Malfunctioning of the autonomic nervous system in patients with chronic fatigue syndrome: a systematic literature review. Eur J Clin Investig. 2014;44(5):516–26.CrossRef
62.
go back to reference Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405(6785):458–62.CrossRefPubMed Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405(6785):458–62.CrossRefPubMed
64.
go back to reference Thayer JF, Hansen AL, Saus-Rose E, Johnsen BH. Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health. Ann Behav Med. 2009;37(2):141–53.PubMedCrossRef Thayer JF, Hansen AL, Saus-Rose E, Johnsen BH. Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health. Ann Behav Med. 2009;37(2):141–53.PubMedCrossRef
65.
go back to reference Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci. 2002;3(8):655–66.PubMedCrossRef Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci. 2002;3(8):655–66.PubMedCrossRef
Metadata
Title
The Invisible Burden of Chronic Fatigue in the Community: a Narrative Review
Authors
Scott J. Fatt
Erin Cvejic
Andrew R. Lloyd
Ute Vollmer-Conna
Jessica Elise Beilharz
Publication date
01-02-2019
Publisher
Springer US
Keyword
Fatigue
Published in
Current Rheumatology Reports / Issue 2/2019
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-019-0804-2
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.