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Open Access 01-12-2019 | Metastasis | Review

The emerging role of WISP proteins in tumorigenesis and cancer therapy

Authors: Yi Liu, Yizuo Song, Miaomiao Ye, Xiaoli Hu, Z. Peter Wang, Xueqiong Zhu

Published in: Journal of Translational Medicine | Issue 1/2019

Abstract

Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression of a broad spectrum of human cancers. Mounting studies have identified that WISP proteins (WISP1-3) exert different biological functions in various human malignancies. Emerging evidence indicates that WISP proteins are critically involved in cell proliferation, apoptosis, invasion and metastasis in cancers. Because the understanding of a direct function of WISP proteins in cancer development and progression has begun to emerge, in this review article, we describe the physiological function of WISP proteins in a variety of human cancers. Moreover, we highlight the current understanding of how the WISP protein is involved in tumorigenesis and cancer progression. Furthermore, we discuss that targeting WISP proteins could be a promising strategy for the treatment of human cancers. Hence, the regulation of WISP proteins could improve treatments for cancer patients.

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Title: The emerging role of WISP proteins in tumorigenesis and cancer therapy
Authors: Yi Liu
Yizuo Song
Miaomiao Ye
Xiaoli Hu
Z. Peter Wang
Xueqiong Zhu
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Metastasis
Breast Cancer
Gastric Cancer
Breast Cancer
Hepatocellular Carcinoma
Gastric Cancer
Hepatocellular Carcinoma
Published in: Journal of Translational Medicine / Issue 1/2019
Electronic ISSN: 1479-5876
DOI: https://doi.org/10.1186/s12967-019-1769-7

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