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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2019

Open Access 01-12-2019 | Lung Cancer | Research

Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

Authors: Ying Wang, Zhengyi Sun, Aipeng Li, Yongsheng Zhang

Published in: World Journal of Surgical Oncology | Issue 1/2019

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Abstract

Background

Inconsistent results according to numerous studies that had investigated the association between serum zinc levels and lung cancer risk were reported. The aim of this study was to explore whether serum zinc levels were lower in lung cancer patients than that in controls.

Methods

We systematically retrieved the databases of PubMed, Wanfang, Cochrane, ScienceDirect website, CNKI, and SinoMed databases for comprehensive relevant studies published before December 2018 and conducted a meta-analysis. Standard mean differences (SMD) were pooled using a random effects model.

Results

Thirty-two articles were eligible to investigate the correlation between serum zinc levels and lung cancer risk, involving 2894 cases and 9419 controls. The pooled results showed sufficient evidence approving the association between serum zinc levels and lung cancer risk. And the serum zinc levels in lung cancer were significantly lower than that in controls (summary SMD = − 0.88, 95% confidence interval (CI) = − 0.94, − 0.82). Meanwhile, consistent results were obtained both in European populations and Asian populations. No publication bias was detected in our analysis.

Conclusions

The present meta-analysis suggested that serum zinc levels were significantly lower in lung cancer patients than that in controls.
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Metadata
Title
Association between serum zinc levels and lung cancer: a meta-analysis of observational studies
Authors
Ying Wang
Zhengyi Sun
Aipeng Li
Yongsheng Zhang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2019
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-019-1617-5

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