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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2018

Open Access 01-12-2018 | Research

Serum magnesium levels and lung cancer risk: a meta-analysis

Authors: Xinghui Song, Xiaoning Zhong, Kaijiang Tang, Gang Wu, Yin Jiang

Published in: World Journal of Surgical Oncology | Issue 1/2018

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Abstract

Background

Whether serum magnesium levels were lower in patients with lung cancer than that in healthy controls is controversial. The aim of this study was to identify and synthesize all citations evaluating the relationship between serum magnesium levels and lung cancer.

Methods

We searched PubMed, WanFang, China National Knowledge Internet (CNKI), and SinoMed databases for relevant studies before December 31, 2017. Two authors independently selected studies, extracted data, and assessed risk of bias.

Results

Eleven citations comprising 707 cases with lung cancer and 7595 healthy controls were included in our study. Serum magnesium levels were not significantly lower in patients with lung cancer [summary SMD = 0.193, 95%CI = − 1.504 to 1.890] when compared to health controls, with significant heterogeneity (I2 = 99.6%, P < 0.001) found. Negative associations were found among Asian populations [summary SMD = 0.229, 95%CI = − 1.637 to 2.094] and European populations [summary SMD = − 0.168, 95%CI = − 0.482 to 0.147]. No publication bias was found using the test of Egger and funnel plot.

Conclusions

Our study suggested that serum magnesium levels had no significant association on lung cancer risk.
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Metadata
Title
Serum magnesium levels and lung cancer risk: a meta-analysis
Authors
Xinghui Song
Xiaoning Zhong
Kaijiang Tang
Gang Wu
Yin Jiang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2018
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-018-1447-x

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